T
Thomas D. Pollard
Researcher at Yale University
Publications - 452
Citations - 59403
Thomas D. Pollard is an academic researcher from Yale University. The author has contributed to research in topics: Arp2/3 complex & Actin. The author has an hindex of 122, co-authored 446 publications receiving 56230 citations. Previous affiliations of Thomas D. Pollard include Salk Institute for Biological Studies & Harvard University.
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Journal ArticleDOI
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
Thomas D. Pollard,Gary G. Borisy +1 more
TL;DR: A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vitro, and mathematical models of the constituent reactions predict the rate of motion.
Journal ArticleDOI
Actin, a Central Player in Cell Shape and Movement
Thomas D. Pollard,John A. Cooper +1 more
TL;DR: Comparisons of quantitative measurements of reactions in live cells with computer simulations of mathematical models will help generate meaningful insights and present a summary of the key questions in the field.
Journal ArticleDOI
Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells
TL;DR: How motile cells regulate actin filament assembly at their leading edge is reviewed, including how Arp2/3 complex is incorporated into the network, and new filaments are capped rapidly, so that activated Arp1/2 complex must be supplied continuously to keep the network growing.
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Actin and Actin-Binding Proteins. A Critical Evaluation of Mechanisms and Functions
Thomas D. Pollard,John A. Cooper +1 more
TL;DR: The present study focuses on the development of binding proteins that bind to the sides of ACTIN FILAMENTS and their applications in the context of nanofiltration.
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The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments
TL;DR: It is shown that Arp2/3 complex purified from Acanthamoeba caps the pointed ends of actin filaments with high affinity and increases the critical concentration for polymerization at the pointed end from 0.6 to 1.0 microM.