Timothy S. Blackwell

TL;DR: This work has shown that activation of NF-kappa B has been linked to ARDS and has been shown to be a critical proximal step in the initiation of neutrophilic inflammation in animal models.

TL;DR: In addition to antibiotic therapy, strategies directed toward enhancing host defense and/or limiting excessive inflammation could be important to improve outcome in P. aeruginosa lung infections.

TL;DR: It is shown that lysophosphatidic acid levels increase in bronchoalveolar lavage fluid following lung injury in the bleomycin model of pulmonary fibrosis, and that mice lacking one of its receptors, LPA1, are markedly protected from fibrosis and mortality in this model.

TL;DR: The NF-kappa B pathway represents an attractive therapeutic target for strategies to control neutrophilic inflammation and lung injury and treatment with the antioxidant N-acetylcysteine 1 h before endotoxin resulted in decreased lung NF- kappa B activation in a dose-dependent manner and diminished cytokine-induced neutrophil chemoattractant mRNA expression in lung tissue.

TL;DR: A complex interaction of cytokines and cytokine-neutralizing molecules probably determines the clinical presentation and course of sepsis, and intervention in this sequence of events to modify the host inflammatory responses may prove to be a beneficial treatment strategy.