V
Valerian V. Dolja
Researcher at Oregon State University
Publications - 148
Citations - 15817
Valerian V. Dolja is an academic researcher from Oregon State University. The author has contributed to research in topics: RNA & Closterovirus. The author has an hindex of 67, co-authored 140 publications receiving 13937 citations. Previous affiliations of Valerian V. Dolja include Russian Academy of Sciences & Texas A&M University System.
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Evolution and Taxonomy of Positive-Strand RNA Viruses: Implications of Comparative Analysis of Amino Acid Sequences
TL;DR: It is hypothesized that all positive-strand RNA viruses and some related double-stranded RNA viruses could have evolved from a common ancestor virus that contained genes for RNA-dependent RNA polymerase, a chymotrypsin-related protease that also functioned as the capsid protein, and possibly an RNA helicase.
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The ancient Virus World and evolution of cells
TL;DR: The existence of several genes that are central to virus replication and structure, are shared by a broad variety of viruses but are missing from cellular genomes suggests the model of an ancient virus world, a flow of virus-specific genes that went uninterrupted from the precellular stage of life's evolution to this day.
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Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate step
Elisabeth J. Chapman,Alexey I. Prokhnevsky,K. Gopinath,Valerian V. Dolja,James C. Carrington +4 more
TL;DR: Three unrelated suppressors from multiple viruses were shown to inhibit microRNA (miRNA) activities and trigger an overlapping series of severe developmental defects in transgenic Arabidopsis thaliana, suggesting that interference with miRNA-directed processes may be a general feature contributing to pathogenicity of many viruses.
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Small RNA binding is a common strategy to suppress RNA silencing by several viral suppressors.
Lóránt Lakatos,Tibor Csorba,Vitantonio Pantaleo,Elisabeth J. Chapman,James C. Carrington,Yu Ping Liu,Valerian V. Dolja,Lourdes Fernández Calvino,Juan José López-Moya,József Burgyán +9 more
TL;DR: It is found that silencing suppressors p19, p21 and HC‐Pro each inhibit the intermediate step of RNA silencing via binding to siRNAs, although the molecular features required for duplex siRNA binding differ among the three proteins.
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Origins and evolution of viruses of eukaryotes: The ultimate modularity
TL;DR: Strikingly, evolution of all classes of eukaryotic viruses appears to have involved fusion between structural and replicative gene modules derived from different sources along with additional acquisitions of diverse genes.