V
Valerie M. Weaver
Researcher at University of California, San Francisco
Publications - 229
Citations - 48521
Valerie M. Weaver is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Extracellular matrix & Stromal cell. The author has an hindex of 83, co-authored 202 publications receiving 40358 citations. Previous affiliations of Valerie M. Weaver include Lawrence Berkeley National Laboratory & National Research Council.
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Journal ArticleDOI
Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
Journal ArticleDOI
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental,Hongmei Yu,Laura Kass,Johnathon N. Lakins,Mikala Egeblad,Janine T. Erler,Sheri F. T. Fong,Katalin Csiszar,Amato J. Giaccia,Wolfgang Weninger,Mitsuo Yamauchi,David L. Gasser,Valerie M. Weaver +12 more
TL;DR: Reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence, and data show how collagenCrosslinking can modulate tissue fibrosis and stiffness to force focal adhesion, growth factor signaling and breast malignancies.
Journal ArticleDOI
The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
Journal ArticleDOI
The extracellular matrix: A dynamic niche in cancer progression
TL;DR: The extracellular matrix (ECM), a complex network of macromolecules with distinctive physical, biochemical, and biomechanical properties, is commonly deregulated and becomes disorganized in diseases such as cancer.
Journal ArticleDOI
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Tony Yeung,Penelope C. Georges,Lisa A. Flanagan,Beatrice Marg,Miguelina Ortiz,Makoto Funaki,Nastaran Zahir,Wenyu Ming,Valerie M. Weaver,Paul A. Janmey,Paul A. Janmey +10 more
TL;DR: The hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands, is supported.