V
Verity A. Letts
Researcher at Howard Hughes Medical Institute
Publications - 22
Citations - 2599
Verity A. Letts is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 20, co-authored 22 publications receiving 2493 citations.
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Journal ArticleDOI
Maps from two interspecific backcross DNA panels available as a community genetic mapping resource
Lucy B. Rowe,J. H. Nadeau,R. Turner,Wayne N. Frankel,Verity A. Letts,Janan Eppig,Minoru S.H. Ko,S. J. Thurston,Edward H. Birkenmeier +8 more
TL;DR: Large quantities of DNA from most tissues of each animal are prepared to create a community resource of interspecific backcross DNA for use by laboratories interested in mapping loci in the mouse.
Journal ArticleDOI
The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit.
Verity A. Letts,Ricardo Felix,Gloria H. Biddlecome,Jyothi Arikkath,Connie L. Mahaffey,A Valenzuela,Frederick S. Bartlett,Yasuo Mori,Kevin P. Campbell,Wayne N. Frankel +9 more
TL;DR: The discovery that the stargazer gene encodes a γ subunit completes the identification of the major subunit types for neuronal Ca2+ channels, namely α1, α 2δ, β and γ, providing a new opportunity to understand how these channels function in the mammalian brain and how they may be targeted in the treatment of neuroexcitability disorders.
Journal ArticleDOI
Ducky Mouse Phenotype of Epilepsy and Ataxia Is Associated with Mutations in the Cacna2d2 Gene and Decreased Calcium Channel Current in Cerebellar Purkinje Cells
Jane Barclay,N Balaguero,Marina Mione,Susan L. Ackerman,Verity A. Letts,Jens Brodbeck,C Canti,Alon Meir,Karen M. Page,Kenro Kusumi,Edward Perez-Reyes,Eric S. Lander,Wayne N. Frankel,RM Gardiner,Annette C. Dolphin,M Rees +15 more
TL;DR: These observations document the first mammalian α2δ mutation and complete the association of each of the major classes of voltage-dependent Ca2+ channel subunits with a phenotype of ataxia and epilepsy in the mouse.
Journal ArticleDOI
Biochemical and biophysical evidence for gamma 2 subunit association with neuronal voltage-activated Ca2+ channels.
Myoung-Goo Kang,Chien-Chang Chen,Ricardo Felix,Verity A. Letts,Wayne N. Frankel,Yasuo Mori,Kevin P. Campbell +6 more
TL;DR: The results suggest that the γ2 subunit is an important constituent of the neuronal Ca2+ channel complex and that it down-regulates neuronal Ca 2+ channel activity.
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Multifactorial inheritance of neural tube defects: localization of the major gene and recognition of modifiers in ct mutant mice.
Paul E. Neumann,Paul E. Neumann,Wayne N. Frankel,Verity A. Letts,John M. Coffin,Andrew J. Copp,Merton Bernfield +6 more
TL;DR: This study provides definitive evidence for multifactorial inheritance in a mouse model of human NTD by describing a linkage analysis that localizes the ct gene to distal chromosome 4 in mice.