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William A. Banks
Researcher at University of Washington
Publications - 584
Citations - 45585
William A. Banks is an academic researcher from University of Washington. The author has contributed to research in topics: Blood–brain barrier & Leptin. The author has an hindex of 106, co-authored 555 publications receiving 40330 citations. Previous affiliations of William A. Banks include Saint Louis University & Fukuoka University.
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Journal ArticleDOI
Leptin enters the brain by a saturable system independent of insulin.
William A. Banks,Abba J. Kastin,Abba J. Kastin,Weitao Huang,Weitao Huang,Jonathan B. Jaspan,Jonathan B. Jaspan,Lawrence M. Maness,Lawrence M. Maness +8 more
TL;DR: Results show that leptin is transported intact from blood to brain by a saturable system and inhibited the influx of 125I-leptin in a dose-dependent manner whereas unlabeled tyrosine and insulin, which have saturable transport systems, were without effect.
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Transport of brain-derived neurotrophic factor across the blood-brain barrier
TL;DR: It is concluded that intact BDNF in the peripheral circulation crosses the blood-brain barrier by a high-capacity, saturable transport system.
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Ghrelin controls hippocampal spine synapse density and memory performance
Sabrina Diano,Susan A. Farr,Susan A. Farr,Stephen C. Benoit,Ewan C. McNay,Ivaldo Silva,Balazs Horvath,F. Spencer Gaskin,F. Spencer Gaskin,Naoko Nonaka,Naoko Nonaka,Laura B. Jaeger,Laura B. Jaeger,William A. Banks,William A. Banks,John E. Morley,John E. Morley,Shirly Pinto,Robert S. Sherwin,Lin Xu,Kelvin A. Yamada,Mark W. Sleeman,Matthias H. Tschöp,Tamas L. Horvath +23 more
TL;DR: It is reported that circulating ghrelin enters the hippocampus and binds to neurons of the hippocampal formation, where it promotes dendritic spine synapse formation and generation of long-term potentiation.
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Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
Matthew J. During,Lei Cao,David S. Zuzga,Jeremy S. Francis,Helen L. Fitzsimons,Xiangyang Jiao,Ross J. Bland,Matthias Klugmann,William A. Banks,Daniel J. Drucker,Colin N. Haile +10 more
TL;DR: Systemic administration of [Ser(2)]exendin(1–9) in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons and represents a promising new target for both cognitive-enhancing and neuroprotective agents.
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From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery
TL;DR: Some of the most important areas that have recently redefined the BBB are reviewed and how they can be applied to the development of CNS therapeutics are discussed.