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William R. Miller
Researcher at University of Texas Health Science Center at Houston
Publications - 43
Citations - 1739
William R. Miller is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Enterococcus faecium & Pseudomonas aeruginosa. The author has an hindex of 17, co-authored 43 publications receiving 1192 citations. Previous affiliations of William R. Miller include University of Texas Health Science Center at San Antonio & Texas A&M University.
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Journal ArticleDOI
Mechanisms of antibiotic resistance in enterococci.
TL;DR: A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches.
Journal ArticleDOI
Effects of Single Nucleotide Polymorphisms on Toll-like Receptor 3 Activity and Expression in Cultured Cells
C. T. Ranjith-Kumar,William R. Miller,Jingchuan Sun,Jin Xiong,Jon Santos,Ian Yarbrough,Roberta J. Lamb,Juliane Mills,Karen E. Duffy,Scott A. Hoose,Mark Cunningham,Andreas Holzenburg,M. Lamine Mbow,Robert T. Sarisky,C. Cheng Kao +14 more
TL;DR: Molecular modeling suggests that two SNPs, N284I and L412F, could affect the packing of the leucine-rich repeating units in TLR3, which are needed for proper signaling in Toll-like receptor 3.
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Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci
TL;DR: This work will review the historical aspects of the development of DAP, as well as the current knowledge on its mechanism of action and pathways to resistance in a clinically relevant context, to review the clinical use of this antibiotic.
Journal ArticleDOI
Multicenter Evaluation of Ceftolozane/Tazobactam for Serious Infections Caused by Carbapenem-Resistant Pseudomonas aeruginosa.
Jose M. Munita,Samuel L. Aitken,William R. Miller,Federico Perez,Rossana Rosa,Luis Shimose,Paola Lichtenberger,Lilian M. Abbo,Rupali Jain,Masayuki Nigo,Audrey Wanger,Rafael Araos,Truc T. Tran,Javier A. Adachi,Robert M. Rakita,Samuel A. Shelburne,Robert A. Bonomo,Cesar A. Arias +17 more
TL;DR: A multicenter, retrospective study of patients infected with carbapenem-resistant Pseudomonas aeruginosa who were treated with ceftolozane/tazobactam found that pneumonia was the most common indication and treatment was successful in 26 of 35 patients.
Journal ArticleDOI
Whole-Genome Analyses of Enterococcus faecium Isolates with Diverse Daptomycin MICs
Lorena Diaz,Truc T. Tran,Jose M. Munita,William R. Miller,Sandra Rincon,Lina P Carvajal,Aye Wollam,Jinnethe Reyes,Diana Panesso,Diana Panesso,Natalia L. Rojas,Yousif Shamoo,Barbara E. Murray,George M. Weinstock,Cesar A. Arias +14 more
TL;DR: The presence of changes in 43 predicted proteins previously associated with DAP resistance in enterococci and staphylococci using the genomes of 19 E. faecium using DAP MICs above the susceptibility breakpoint suggests that genotypic information may be crucial to predict response to DAP plus β-lactam combinations.