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Wolfgang Löscher
Researcher at University of Veterinary Medicine Vienna
Publications - 380
Citations - 29178
Wolfgang Löscher is an academic researcher from University of Veterinary Medicine Vienna. The author has contributed to research in topics: Epilepsy & Status epilepticus. The author has an hindex of 82, co-authored 347 publications receiving 25535 citations. Previous affiliations of Wolfgang Löscher include University of Veterinary Medicine Hanover & Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
The neurobiology of antiepileptic drugs.
TL;DR: The subtle biophysical modifications in channel behaviour that are induced by AEDs are often functionally opposite to defects in channel properties that are caused by mutations associated with epilepsy in humans.
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Drug resistance in brain diseases and the role of drug efflux transporters
TL;DR: There is increasing evidence that drug efflux transporters have an important role in drug-resistant brain disorders, and this information should allow more efficacious treatment strategies to be developed.
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Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations
Wolfgang Löscher,Dieter Schmidt +1 more
TL;DR: Animal models for the search of new antiepileptic drugs: models of seizure states vs. models of epilepsy, models with electrical or chemical seizure induction, and topical convulsant metals models are presented.
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Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs.
TL;DR: Preclinical strategies of AED discovery and development need a conceptual shift that is moving away from using models that identify therapies for the symptomatic treatment of epilepsy to those that may be useful for identifying therapies that are more effective in the refractory population.
Journal ArticleDOI
Blood-Brain Barrier Active Efflux Transporters: ATP-Binding Cassette Gene Family
TL;DR: Modulation of ABC efflux transporters at the BBB forms a novel strategy to enhance the penetration of drugs into the brain and may yield new therapeutic options for drug-resistant CNS diseases.