抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Metamaterials are artificially fabricated materials that allow for the control of light and acoustic waves in a manner that is not possible in nature. This Review covers the recent developments in the study of so-called metasurfaces, which offer the possibility of controlling light with ultrathin, planar optical components. Conventional optical components such as lenses, waveplates and holograms rely on light propagation over distances much larger than the wavelength to shape wavefronts. In this way substantial changes of the amplitude, phase or polarization of light waves are gradually accumulated along the optical path. This Review focuses on recent developments on flat, ultrathin optical components dubbed 'metasurfaces' that produce abrupt changes over the scale of the free-space wavelength in the phase, amplitude and/or polarization of a light beam. Metasurfaces are generally created by assembling arrays of miniature, anisotropic light scatterers (that is, resonators such as optical antennas). The spacing between antennas and their dimensions are much smaller than the wavelength. As a result the metasurfaces, on account of Huygens principle, are able to mould optical wavefronts into arbitrary shapes with subwavelength resolution by introducing spatial variations in the optical response of the light scatterers. Such gradient metasurfaces go beyond the well-established technology of frequency selective surfaces made of periodic structures and are extending to new spectral regions the functionalities of conventional microwave and millimetre-wave transmit-arrays and reflect-arrays. Metasurfaces can also be created by using ultrathin films of materials with large optical losses. By using the controllable abrupt phase shifts associated with reflection or transmission of light waves at the interface between lossy materials, such metasurfaces operate like optically thin cavities that strongly modify the light spectrum. Technology opportunities in various spectral regions and their potential advantages in replacing existing optical components are discussed.

Flat Optics With Designer Metasurfaces

The electronic and optical properties and the recent progress in applications of 2D semiconductor transition metal dichalcogenides with emphasis on strong excitonic effects, and spin- and valley-dependent properties are reviewed. Recent advances in the development of atomically thin layers of van der Waals bonded solids have opened up new possibilities for the exploration of 2D physics as well as for materials for applications. Among them, semiconductor transition metal dichalcogenides, MX2 (M = Mo, W; X = S, Se), have bandgaps in the near-infrared to the visible region, in contrast to the zero bandgap of graphene. In the monolayer limit, these materials have been shown to possess direct bandgaps, a property well suited for photonics and optoelectronics applications. Here, we review the electronic and optical properties and the recent progress in applications of 2D semiconductor transition metal dichalcogenides with emphasis on strong excitonic effects, and spin- and valley-dependent properties.

Photonics and optoelectronics of 2D semiconductor transition metal dichalcogenides

Metamaterials, or engineered materials with rationally designed, subwavelength-scale building blocks, allow us to control the behavior of physical fields in optical, microwave, radio, acoustic, heat transfer, and other applications with flexibility and performance that are unattainable with naturally available materials. In turn, metasurfaces-planar, ultrathin metamaterials-extend these capabilities even further. Optical metasurfaces offer the fascinating possibility of controlling light with surface-confined, flat components. In the planar photonics concept, it is the reduced dimensionality of the optical metasurfaces that enables new physics and, therefore, leads to functionalities and applications that are distinctly different from those achievable with bulk, multilayer metamaterials. Here, we review the progress in developing optical metasurfaces that has occurred over the past few years with an eye toward the promising future directions in the field.

/pdf/planar-photonics-with-metasurfaces-1sfd62lis7.pdf

Planar Photonics with Metasurfaces

Subwavelength resolution imaging requires high numerical aperture (NA) lenses, which are bulky and expensive. Metasurfaces allow the miniaturization of conventional refractive optics into planar structures. We show that high-aspect-ratio titanium dioxide metasurfaces can be fabricated and designed as metalenses with NA = 0.8. Diffraction-limited focusing is demonstrated at wavelengths of 405, 532, and 660 nm with corresponding efficiencies of 86, 73, and 66%. The metalenses can resolve nanoscale features separated by subwavelength distances and provide magnification as high as 170×, with image qualities comparable to a state-of-the-art commercial objective. Our results firmly establish that metalenses can have widespread applications in laser-based microscopy, imaging, and spectroscopy.

Metalenses at visible wavelengths: Diffraction-limited focusing and subwavelength resolution imaging.

The precise manipulation of a propagating wave using phase control is a fundamental building block of optical systems. The wavefront of a light beam propagating across an interface can be modified arbitrarily by introducing abrupt phase changes. We experimentally demonstrated unparalleled wavefront control in a broadband optical wavelength range from 1.0 to 1.9 micrometers. This is accomplished by using an extremely thin plasmonic layer (~λ/50) consisting of an optical nanoantenna array that provides subwavelength phase manipulation on light propagating across the interface. Anomalous light-bending phenomena, including negative angles of refraction and reflection, are observed in the operational wavelength range.

http://science.sciencemag.org/content/sci/335/6067/427.full.pdf

Broadband Light Bending with Plasmonic Nanoantennas

Holographic techniques provide phase and amplitude information for images of objects, but normally the hologram thickness is comparable to the light wavelength used. Ni et al. present ultra-thin plasmonic holograms that control amplitude and phase in the visible region and are just 30 nm thick.

/pdf/metasurface-holograms-for-visible-light-1s5iyybhfv.pdf

Metasurface holograms for visible light

Metamaterial-based optical cloaks have thus far used volumetric distribution of the material properties to gradually bend light and thereby obscure the cloaked region Hence, they are bulky and hard to scale up and, more critically, typical carpet cloaks introduce unnecessary phase shifts in the reflected light, making the cloaks detectable Here, we demonstrate experimentally an ultrathin invisibility skin cloak wrapped over an object This skin cloak conceals a three-dimensional arbitrarily shaped object by complete restoration of the phase of the reflected light at 730-nanometer wavelength The skin cloak comprises a metasurface with distributed phase shifts rerouting light and rendering the object invisible In contrast to bulky cloaks with volumetric index variation, our device is only 80 nanometer (about one-ninth of the wavelength) thick and potentially scalable for hiding macroscopic objects

http://science.sciencemag.org/content/sci/349/6254/1310.full.pdf

An ultrathin invisibility skin cloak for visible light

Much research activity is being devoted to the design and fabrication of metamaterials, artificially tailored composites with the counter-intuitive optical property of a negative refraction index. There is an exciting and wide range of possible applications that could be developed with such negative-index materials, including invisibility cloaks and 'perfect' lenses, but a major hurdle is that the performance is severely limited by absorption losses. Vladimir Shalaev and colleagues now demonstrate an approach that could lead to a breakthrough in this area; they have incorporated an optical gain medium within the metamaterial as a way to compensate the intrinsic loss, and show that optical pumping leads to a significantly improved negative refraction index and performance-related figure-of-merit at visible wavelengths. The study confirms that it is possible to design an optical metamaterial that is not limited by the intrinsic loss of its metal constituent. Metamaterials have the counterintuitive optical property of negative refraction index. They have a wide range of possible applications, including 'invisibility cloaks' and perfect lenses, but their performance is severely limited by absorption losses. These authors have incorporated an optical gain medium within a metamaterial as a way to compensate the intrinsic loss, and show that optical pumping leads to a significantly improved negative refraction index and figure of merit within the 722–738-nm visible wavelength range. The recently emerged fields of metamaterials and transformation optics promise a family of exciting applications such as invisibility, optical imaging with deeply subwavelength resolution and nanophotonics with the potential for much faster information processing. The possibility of creating optical negative-index metamaterials (NIMs) using nanostructured metal–dielectric composites has triggered intense basic and applied research over the past several years1,2,3,4,5,6,7,8,9,10. However, the performance of all NIM applications is significantly limited by the inherent and strong energy dissipation in metals, especially in the near-infrared and visible wavelength ranges11,12. Generally the losses are orders of magnitude too large for the proposed applications, and the reduction of losses with optimized designs seems to be out of reach. One way of addressing this issue is to incorporate gain media into NIM designs13,14,15,16. However, whether NIMs with low loss can be achieved has been the subject of theoretical debate17,18. Here we experimentally demonstrate that the incorporation of gain material in the high-local-field areas of a metamaterial makes it possible to fabricate an extremely low-loss and active optical NIM. The original loss-limited negative refractive index and the figure of merit (FOM) of the device have been drastically improved with loss compensation in the visible wavelength range between 722 and 738 nm. In this range, the NIM becomes active such that the sum of the light intensities in transmission and reflection exceeds the intensity of the incident beam. At a wavelength of 737 nm, the negative refractive index improves from −0.66 to −1.017 and the FOM increases from 1 to 26. At 738 nm, the FOM is expected to become macroscopically large, of the order of 106. This study demonstrates the possibility of fabricating an optical negative-index metamaterial that is not limited by the inherent loss in its metal constituent.

https://docs.lib.purdue.edu/cgi/viewcontent.cgi?article=1686&context=nanopub

Loss-free and active optical negative-index metamaterials

Scientists in the USA have developed powerful ultrathin planar lenses made from 30-nm-thick perforated gold films. These plasmonic metalenses, created by Xingjie Ni and co-workers at Purdue University, focus a beam of visible light into a spot measuring only slight larger than the wavelength of operation. The devices rely on a concentric pattern of Babinet-inverted nano-antennas (nano-avoids) in a metal film that manipulate the phase of the incident light. For example, a 4-μm-diameter lens provides a focal length of 2.5 μm at a wavelength of 676 nm. The lenses are designed to work at two orthogonal linear polarizations and in future could be suitable for use as miniature couplers or light concentrators in on-chip optical devices.

/pdf/ultra-thin-planar-babinet-inverted-plasmonic-metalenses-4sb44wmyle.pdf

Xingjie Ni

Papers

Broadband Light Bending with Plasmonic Nanoantennas

Metasurface holograms for visible light

An ultrathin invisibility skin cloak for visible light

Loss-free and active optical negative-index metamaterials

Ultra-thin, planar, Babinet-inverted plasmonic metalenses