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Yao Zhao
Researcher at Chinese Academy of Sciences
Publications - 266
Citations - 11331
Yao Zhao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Supply chain. The author has an hindex of 37, co-authored 221 publications receiving 7305 citations. Previous affiliations of Yao Zhao include Rutgers University & University of Warwick.
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Journal ArticleDOI
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xiaoyu Du,Yechun Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xiaofeng Li,Leike Zhang,Chao Peng,Yinkai Duan,Jing Yu,Lin Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xing-Lou Yang,Tian You,Liu X,Xiuna Yang,Fang Bai,Hong Liu,Xiang Liu,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +35 more
TL;DR: A programme of structure-assisted drug design and high-throughput screening identifies six compounds that inhibit the main protease of SARS-CoV-2, demonstrating the ability of this strategy to isolate drug leads with clinical potential.
Journal ArticleDOI
Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Yan Gao,Yan Gao,Liming Yan,Yucen Huang,Fengjiang Liu,Yao Zhao,Lin Cao,Tao Wang,Qianqian Sun,Zhenhua Ming,Lianqi Zhang,Ji Ge,Litao Zheng,Ying Zhang,Haofeng Wang,Haofeng Wang,Yan Zhu,Chen Zhu,Tianyu Hu,Tian Hua,Bing Zhang,Xiuna Yang,Jun Li,Haitao Yang,Zhi-Jie Liu,Wenqing Xu,Luke W. Guddat,Quan Wang,Zhiyong Lou,Zihe Rao +29 more
TL;DR: The structure of the COVID-19 virus polymerase essential for viral replication provides a basis for the design of new antiviral drugs that target viral RdRp, also named nsp12, and it appears to be a primary target for the antiviral drug remdesivir.
Journal ArticleDOI
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.
Wenhao Dai,Wenhao Dai,Bing Zhang,Xia Ming Jiang,Haixia Su,Jian Li,Jian Li,Yao Zhao,Xiong Xie,Zhenming Jin,Jingjing Peng,Fengjiang Liu,Chunpu Li,You Li,Fang Bai,Haofeng Wang,Xi Cheng,Xiaobo Cen,Shulei Hu,Xiuna Yang,Jiang Wang,Xiang Liu,Gengfu Xiao,Hualiang Jiang,Zihe Rao,Lei Ke Zhang,Yechun Xu,Haitao Yang,Hong Liu +28 more
TL;DR: Two peptidomimetic aldehydes were designed, synthesized, and evaluated as antiviral drug candidates, and both exhibited excellent inhibitory activity and potent anti-SARS-CoV-2 infection activity.
ComponentDOI
Structure of Mpro from COVID-19 virus and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xingyu Du,Ya-Xi Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xingzhou Li,L. Z. Zhang,Chao Peng,Yinkai Duan,Jing Yu,Linfang Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xuejie Yang,Tian You,Liu X,Fang Bai,He-Qun Liu,Luke W. Guddat,Wenbo Xu,Wenbo Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Haiying Jiang,Haiying Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +33 more
TL;DR: The results demonstrate the efficacy of this screening strategy, which can lead to the rapid discovery of drug leads with clinical potential in response to new infectious diseases where no specific drugs or vaccines are available.
Journal ArticleDOI
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.
Zhenming Jin,Zhenming Jin,Yao Zhao,Yuan Sun,Bing Zhang,Haofeng Wang,Haofeng Wang,Yan Wu,Yan Zhu,Chen Zhu,Tianyu Hu,Xiaoyu Du,Xiaoyu Du,Yinkai Duan,Jing Yu,Xiaobao Yang,Xiuna Yang,Kailin Yang,Xiang Liu,Luke W. Guddat,Gengfu Xiao,Leike Zhang,Haitao Yang,Zihe Rao,Zihe Rao,Zihe Rao +25 more
TL;DR: The X-ray crystal structure of SARS-CoV-2 with inhibitor carmofur reveals the mechanism of action of this compound and opens the way to develop more potent drugs.