Y
Ying-Jan Wang
Researcher at National Taiwan University
Publications - 15
Citations - 1938
Ying-Jan Wang is an academic researcher from National Taiwan University. The author has contributed to research in topics: Apoptosis & Medicine. The author has an hindex of 10, co-authored 11 publications receiving 1739 citations. Previous affiliations of Ying-Jan Wang include University of Hong Kong & National Kaohsiung Marine University.
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Journal ArticleDOI
Stability of curcumin in buffer solutions and characterization of its degradation products
Ying-Jan Wang,Min-Hsiung Pan,Ann-Lii Cheng,Liang-In Lin,Yuan Soon Ho,Chang-Yao Hsieh,Jen-Kun Lin +6 more
TL;DR: It was shown that decomposition was pH-dependent and occurred faster at neutral-basic conditions and vanillin, ferulic acid, feruloyl methane were identified as minor degradation products and the amount of vanillin increased with incubation time.
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Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells.
TL;DR: The results indicate that wild‐type p53 and p21/WAF1/CIP1 expression was elevated in human cancer cells by exposure to NO and suggest that this may eventually promote apoptosis.
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5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells
Min-Hsiung Pan,You-Syuan Lai,Ching Shu Lai,Ying-Jan Wang,Shiming Li,Chih-Yu Lo,Slavik Dushenkov,Chi-Tang Ho +7 more
TL;DR: The findings suggest that 5-OH-HxMF creates an oxidative cellular environment that induces DNA damage and GADD153 gene activation, which in turn helps trigger apoptosis in HL-60 cells, and ROS were proven an important inducer in this apoptotic process.
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Suppression of nitric oxide-induced apoptosis by n-acetyl-l-cysteine through modulation of glutathione, bcl-2, and bax protein levels
TL;DR: The results suggest that the protective effect of LNAC may be linked to its inducement of increases in cellular GSH and bcl‐2 protein levels and to its suppression of cellular bax protein in treated cells.
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Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging
TL;DR: Elevated amounts of modified DNA bases were found in most cancerous tissues when compared to the controls, and the association of the modified bases with the processes of aging and carcinogenesis deserves further investigation.