Yoshiaki Taniyama

TL;DR: Transfection of p53 plasmid with the use of this method should be useful for safe clinical gene therapy without a viral vector system, and no apparent toxicity could be detected in blood vessels transfected withplasmid DNA with ultrasound and Optison.

TL;DR: Despite no obstructive lesion of the vessel, TIMI 2 is caused by advanced microvascular damage and is a highly specific, although not sensitive, predictor of poor functional outcomes in patients with acute myocardial infarction.

TL;DR: Transfection of HGF plasmid by the ultrasound-Optison method could be useful for safe clinical gene therapy to treat peripheral arterial disease without a viral vector system.

TL;DR: Intravenous nicorandil in conjunction with coronary angioplasty is associated with better functional and clinical outcomes compared to angiopLasty alone in patients with an anterior AMI, and myocardial contrast echocardiography findings imply that an improvement in microvascular function with nicor andil may be attributable to this better outcome.

TL;DR: In the presence of decreased endogenous HGF, administration of rhHGF induced therapeutic angiogenesis in the rabbit ischemic hind limb model, as potential cytokine supplement therapy for peripheral arterial disease.