Y
Yuan Chu
Researcher at Central South University
Publications - 6
Citations - 332
Yuan Chu is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 1, co-authored 1 publications receiving 237 citations.
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Journal ArticleDOI
HIV protease inhibitors: a review of molecular selectivity and toxicity
Zhengtong Lv,Yuan Chu,Yong Wang +2 more
TL;DR: From the chemical structures of HIV protease inhibitors and their possible off-target molecules, hints for optimizing the molecular selectivity of the inhibitors are obtained to provide help in the design of new compounds with enhanced bioavailability and reduced side effects.
Journal ArticleDOI
Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023
Yongbiao Xue,Yiming Bao,Zhang-Jin Zhang,Wenming Zhao,Jingfa Xiao,Shunmin He,Guoqing Zhang,Yixue Li,Guoping Zhao,Runsheng Chen,Yingke Ma,Meili Chen,Cuiping Li,Shuai Jiang,Dong Zou,Zheng Gong,Xuetong Zhao,Yanqing Wang,Junwei Zhu,Shuhui Song,Yunchao Ling,Yiwei Wang,Jiaxin Yang,Xinhao Zhuang,Guangya Duan,Gangao Wu,Xiaoning Chen,Dongmei Tian,Zhaohua Li,Yanling Sun,Zhenglin Du,Lili Hao,Yuan Gao,Bixia Tang,Yang Zhang,Hao Zhang,Zaichao Zhang,Qiheng Qian,Zhewen Zhang,Hailong Kang,Tian-Miao Huang,Zhiqiang Xia,Xincheng Zhou,Jinquan Chao,Zhonghuang Wang,Sisi Zhang,Weimin Tian,Wenquan Wang,Song Wu,Yue Huang,Mochen Zhang,Guoliang Wang,Xinchang Zheng,Wenting Zong,Wei Zhao,Peiqi Xing,Rujiao Li,Zhao-Qing Liu,Mingming Lu,Fengchun Yang,Jialin Mai,Qianwen Gao,Xiaowei Xu,Hong Yu Kang,Li Hou,Yunfei Shang,Qiheng Qain,Jie Liu,Meiye Jiang,Congfan Bu,Jinyue Wang,Jingyao Zeng,Jiao Li,Siyu Pan,Hongen Kang,Xinxuan Liu,Shi-Qi Lin,Na Yuan,Peilin Jia,Zhuang Xiong,Fei Yang,Xu Chen,Tingting Chen,Caixia Yu,Lili Dong,Shuang Zhai,Yubin Sun,Qian Chen,Xiao-Yu Yang,Xin Zhang,Zhen-chi Sang,Yonggang Wang,Yi Zhao,Huanxin Chen,Li-Zhen Lan,Anke Wang,Yaokai Jia,Yi-yun Pan,Xiaonan Liu,Rong-he Zhang,Yi Wang,Lina Ma,Xu Fei Teng,Lun Li,Nan Lin,Ying Cui,Tong Jin,Enhui Jin,Tao Zhang,Tianyi Xu,Ming-Xuan Chen,Guang Yi Niu,Rong-yang Pan,Tongtong Zhu,Yuan Chu,Jian Sang,Yuanpu Zhang,Zhen-Ni Wang,Yuansheng Zhang,Qi Yao,Xinran Zhang,Xutong Guo,Zhaohua Li,Lin Liu,Changrui Feng,Yuxin Qin,Wei Jing,Sicheng Luo,Zishan Wu,Qianpeng Li,Pei Liu,Yongqing Sun,Z. Fan,Wenhua Shen,An-Yuan Guo,Zhixiang Zuo,Jian Ren,Xinxin Zhang,Yun Xiao,Xia Li,Dan Liu,Chi Zhang,Yu Xue,Zheng Zhao,Tao Jiang,Wanying Wu,Fan-ping Zhao,Xianwen Meng,Yujie Gou,Miaomiao Chen,Di Peng,Hao Luo,Feng Gao,Wanshan Ning,Wan Liu,Ruifang Cao,Yuxiang Wei,Chun-Jie Liu,Hao Yuan,Tianhan Su,Yong Zhang,Chen Zhou,Pengyu Wang,Yincong Zhou,Guo Guo,Qiong Zhang,Shanshan Fu,Xiaodan Tan,Dachao Tang,Weizhi Zhang,Mei Luo,Yubin Xie,Ya-Ru Miao,Xinhe Huang,Zihao Feng,Xingyu Liao,Xin-Xia Gao,Jianxin Wang,Gui-Yan Xie,Chunhui Yuan,De-Chang Yang,Feng Tian,Ge Gao,Wenyi Wu,Cheng Han,Qing-Fua Cui,Chun-hong Xiao,Chuan Li,Xiaotong Luo,Qing Tang +189 more
TL;DR: The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a family of database resources to support global academic and industrial communities as discussed by the authors .
Journal ArticleDOI
Transient Receptor Potential Vanilloid-1 (TRPV1) Alleviates Hepatic Fibrosis via TGF-β Signaling
Ke Qian,Xiaohua Lei,Guoxing Liu,Yu Fang,Chengzhi Xie,Xiao-long Wu,Qiang Liu,Gao Liu,Zhenyu Cao,Ju Zhang,Tao Kuang,Likun Yan,Jie Fu,Huihui Du,Zhiqiang Liu,Yuan Chu,Gending Xu,Hirofumi Yamamoto,Masaki Mori,Xinjian Liang,Xundi Xu +20 more
TL;DR: The obtained data suggest that TRPV1 may alleviate CCl4-induced hepatic fibrosis and attenuate the effect of TGF-β on HSC activation, proliferation, and apoptosis, which overall implies that targeting TRpV1 channel activity may be an effective therapeutic strategy for treating liver fibrosis.
Journal ArticleDOI
SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes
TL;DR: In this article , the effects of SLC12A5 in HCC have not been determined and new effective treatments are needed, which plays important roles in multiple complex pathological states and is overexpressed in a variety of malignancies.
Journal ArticleDOI
TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
Qiang Liu,Xiaohua Lei,Zhenyu Cao,Ju Zhang,Likun Yan,Jie Fu,Qing Tong,Weiwei Qin,Yaoli Shao,Chun Tao Liu,Zhiqiang Liu,Zicheng Wang,Yuan Chu,Gezhi Xu,Siyuan Liu,Xueyi Wen,Hirofumi Yamamoto,Masaki Mori,Xinjian Liang,Xundi Xu +19 more
TL;DR: In this paper , the effect of TRPM8 deficiency on liver fibrosis was evaluated using specimens obtained from classic murine models of Liver fibrosis, namely wild-type (WT) andTRPM8-/- (KO) fibrotic mice after carbon tetrachloride (CCl4) or bile duct ligation (BDL) treatment.