Yves Guiot

TL;DR: Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders.

TL;DR: The average β‐cell mass is about 39% lower in T2D subjects compared with matched controls, and its decrease with duration of the disease could be a consequence of diabetes that, with further impairment of insulin secretion, contributes to the progressive deterioration of glucose homeostasis.

TL;DR: In rats, the peritoneum site seems not appropriate for promoting the engraftment of encapsulated pig islets, and Kidney subcapsular and subcutaneous spaces represent an interesting alternative.

TL;DR: After 1 wk of culture in G30, the loss of glucose stimulation of insulin secretion in the physiological range of glucose concentrations (G5-G10) results from the combination of an increased sensitivity to glucose of both triggering and amplifying pathways of insulin gland secretion and an approximately 50% reduction in the maximal glucose stimulationof insulin secretion.

TL;DR: The paradoxical upregulation of adiponectin in muscle of obese and diabetic mice may result from lipotoxicity and related oxidative stress and could be viewed as a local protection to counteract ectopic fat deposition and oxidative damage.