Z
Zhen Wang
Researcher at University of Mississippi Medical Center
Publications - 47
Citations - 2531
Zhen Wang is an academic researcher from University of Mississippi Medical Center. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 16, co-authored 30 publications receiving 1776 citations. Previous affiliations of Zhen Wang include University of Arkansas for Medical Sciences.
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Journal ArticleDOI
Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms.
TL;DR: With prolonged obesity and development of target organ injury, obesity-associated hypertension becomes more difficult to control, often requiring multiple antihypertensive drugs and treatment of other risk factors, including dyslipidemia, insulin resistance and diabetes mellitus, and inflammation.
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Obesity, hypertension, and chronic kidney disease.
Michael E. Hall,Jussara M. do Carmo,Alexandre A. da Silva,Luis A. Juncos,Zhen Wang,John E. Hall +5 more
TL;DR: Body weight reduction, via caloric restriction and increased physical activity, is an important first step for management of obesity, hypertension, and chronic kidney disease, however, this strategy may not be effective in producing long-term weight loss or in preventing cardiorenal and metabolic consequences in many obese patients.
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Obesity, kidney dysfunction and hypertension: mechanistic links.
TL;DR: The authors discuss the complex interactions between renal, hormonal and nervous system factors that link excess adiposity with elevated blood pressure and chronic obesity-associated hypertension.
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Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
TL;DR: Resveratrol may have a dual mechanism of action to restore the renal microcirculation and scavenge reactive nitrogen species, thus protecting the tubular epithelium even when administered after the onset of sepsis.
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Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury.
Zhen Wang,Joseph H. Holthoff,Kathryn A. Seely,Elina Pathak,Horace J. Spencer,Neriman Gokden,Philip R. Mayeux +6 more
TL;DR: The first time-dependent studies to document changes in renal hemodynamic changes occur early after sepsis demonstrate that targeting the later oxidant generation can break the cycle of injury and enable the microcirculation and renal function to recover.