Z
Zhirong Zhang
Researcher at Sichuan University
Publications - 470
Citations - 17104
Zhirong Zhang is an academic researcher from Sichuan University. The author has contributed to research in topics: Drug delivery & In vivo. The author has an hindex of 59, co-authored 437 publications receiving 12893 citations. Previous affiliations of Zhirong Zhang include Capital Medical University.
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Enhanced rifampicin delivery to alveolar macrophages by solid lipid nanoparticles
TL;DR: In vivo delivery efficiency and the selectivity of RFP-SLNs were further verified in Sprague–Dawley rats and demonstrated that solid lipid nanoparticles are a promising strategy for the delivery of rifampicin to alveolar macrophages selectively.
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Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin.
TL;DR: This study provides the evidence of using pHPMA as dissociable "mucus-inert" agent to enhance mucus permeation of NPs, and validates a strategy to overcome the multiple absorption barriers using NP platform with Dissociable hydrophilic coating and drug-loaded CPP-rich core.
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Preformed albumin corona, a protective coating for nanoparticles based drug delivery system.
Qiang Peng,Shu Zhang,Qin Yang,Ting Zhang,Xue-Qin Wei,Li Jiang,Chao-Liang Zhang,Qianming Chen,Zhirong Zhang,Yunfeng Lin +9 more
TL;DR: The successful application of the preformed albumin corona is demonstrated in inhibiting the plasma proteins adsorption and decreasing the complement activation, and ultimately in prolonging the blood circulation time and reducing the toxicity of the polymeric PHBHHx NPs.
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Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease
Mengke Qu,Qing Lin,Luyi Huang,Yao Fu,Luyao Wang,Shanshan He,Yu Fu,Shengyong Yang,Zhirong Zhang,Ling Zhang,Xun Sun +10 more
TL;DR: It is suggested that blood exosomes can be used as a promising drug delivery platform for targeted therapy against PD and other diseases of the central nervous system.
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Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport
TL;DR: It was found the existence of mucus was propitious to the transport of insulin from both modified and unmodified nanoparticles, and CSK peptide modified TMC nanoparticles showed sufficient effectiveness as goblet cell-targeting nanocarriers for oral delivery of insulin.