Z
Zhongjian Cheng
Researcher at Temple University
Publications - 40
Citations - 2090
Zhongjian Cheng is an academic researcher from Temple University. The author has contributed to research in topics: Endothelial dysfunction & Endothelium. The author has an hindex of 25, co-authored 40 publications receiving 1691 citations. Previous affiliations of Zhongjian Cheng include New York University & University of Calgary.
Papers
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Journal ArticleDOI
Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
Venkata Naga Srikanth Garikipati,Suresh K Verma,Zhongjian Cheng,Dongming Liang,May Truongcao,Maria Cimini,Yujia Yue,Grace Huang,Chunlin Wang,Cindy Benedict,Yan Tang,Vandana Mallaredy,Jessica Ibetti,Laurel A. Grisanti,Sarah M. Schumacher,Erhe Gao,Sudarsan Rajan,Jeremy E. Wilusz,David A. Goukassian,Steven R. Houser,Walter J. Koch,Raj Kishore +21 more
TL;DR: It is shown that AAV-mediated delivery of the circRNA circFndc3b prevents cardiomyocyte apoptosis, enhances angiogenesis, and attenuates LV dysfunction post-MI in mice by regulating FUS-VEGF-A signalling.
Journal Article
Angiotensin II and vascular inflammation.
TL;DR: The pro-inflammatory action of Ang II may help to understand the molecular mechanisms of hypertension- and diabetes-induced vascular complication as well as the pleiotropic actions of drugs interfering with RAS.
Journal ArticleDOI
Endothelial Dysfunction and Salt-Sensitive Hypertension in Spontaneously Diabetic Goto-Kakizaki Rats
Zhongjian Cheng,Timo Vaskonen,Ilkka Tikkanen,Kaisa Nurminen,Heikki Ruskoaho,Heikki Vapaatalo,Dominik N. Müller,Joon-Keun Park,Friedrich C. Luft,Eero Mervaala +9 more
TL;DR: It is concluded that hypertension in GK rats is salt sensitive and associated with endothelial dysfunction and perivascular inflammation and AT1 receptor blockade ameliorates inflammation during a low-sodium diet and partially protects against salt-induced vascular damage by blood pressure–independent mechanisms.
Journal ArticleDOI
Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes
Eero Mervaala,Zhongjian Cheng,Ilkka Tikkanen,Risto Lapatto,Kaisa Nurminen,Heikki Vapaatalo,Dominik N. Müller,Anette Fiebeler,Ursula Ganten,Detlev Ganten,Friedrich C. Luft +10 more
TL;DR: Overproduction of Ang II in dTGR induces pronounced endothelial dysfunction, whereas the sensitivity of vascular smooth muscle cells to nitric oxide is unaltered, suggesting hypertension-associated generalized changes in the vascular function rather than a receptor-specific desensitization.
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Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction--a novel mechanism for maintaining vascular function.
TL;DR: It is suggested that anti-inflammatory/immunosuppressive cytokines serve as novel therapeutic targets for inhibiting endothelial dysfunction, vascular inflammation and cardio- and cerebro-vascular diseases.