Institution
Aga Khan University Hospital
Healthcare•Karachi, Pakistan•
About: Aga Khan University Hospital is a healthcare organization based out in Karachi, Pakistan. It is known for research contribution in the topics: Population & Medicine. The organization has 3001 authors who have published 3485 publications receiving 40110 citations.
Topics: Population, Medicine, Health care, Pregnancy, Cancer
Papers published on a yearly basis
Papers
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University Health Network1, University of Toronto2, Memorial Sloan Kettering Cancer Center3, Charles University in Prague4, University of Pittsburgh5, Ontario Institute for Cancer Research6, Princess Margaret Cancer Centre7, Aga Khan University Hospital8, Virginia Mason Medical Center9, Harvard University10
TL;DR: Novel and recurrent gene rearrangements in PRKD1–3 primarily in CAMSG are described, suggesting a possible pathogenetic dichotomy from “classic” PLGA.
Abstract: Polymorphous low-grade adenocarcinoma (PLGA) and cribriform adenocarcinoma of minor salivary gland (CAMSG) are low-grade carcinomas arising most often in oral cavity and oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants of one spectrum, as they appear to have significant overlap, but also clinicopathologic differences. As many salivary carcinomas harbor recurrent translocations, paired-end RNA sequencing and FusionSeq data analysis was applied for novel fusion discovery on two CAMSGs and two PLGAs. Validated rearrangements were then screened by fluorescence in situ hybridization (FISH) in 60 cases. Histologic classification was performed without knowledge of fusion status and included: 21 CAMSG, 18 classic PLGA, and 21 with "mixed/indeterminate" features. The RNAseq of 2 CAMSGs showed ARID1A-PRKD1 and DDX3X-PRKD1 fusions, respectively, while no fusion candidates were identified in two PLGAs. FISH for PRKD1 rearrangements identified 11 additional cases (22%), two more showing ARID1A-PRKD1 fusions. As PRKD2 and PRKD3 share similar functions with PRKD1 in the diacylglycerol and protein kinase C signal transduction pathway, we expanded the investigation for these genes by FISH. Six additional cases each showed PRKD2 and PRKD3 rearrangements. Of the 26 (43%) fusion-positive tumors, there were 16 (80%) CAMSGs and 9 (45%) indeterminate cases. A PRKD2 rearrangement was detected in one PLGA (6%). We describe novel and recurrent gene rearrangements in PRKD1-3 primarily in CAMSG, suggesting a possible pathogenetic dichotomy from "classic" PLGA. However, the presence of similar genetic findings in half of the indeterminate cases and a single PLGA suggests a possible shared pathogenesis for these tumor types.
118 citations
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TL;DR: In this article, a descriptive qualitative research design was used to explore the registered nurses' perceptions regarding the high turnover rates among nurses at a Tertiary care university hospital, where data was collected from nurses working at various speciality areas, which were: Critical Care, Medical and Surgical Care, Ambulatory Care, Maternal/Child and Emergency departments.
Abstract: Hospitals are facing serious challenges to provide high quality care with current nursing shortages. Nursing shortages are of major concern for Nursing Management, clinicians and administrators as they lead to impact on quality of care. Under-stressed, frustrated and demoralized nurses give rise to concern for hospital Nursing Management in providing quality care according to set standards. A descriptive qualitative research design was used to explore the registered nurses' perceptions regarding the high turnover rates among nurses at a Tertiary Care University Hospital. Data was collected from nurses working at various speciality areas, which were: Critical Care, Medical and Surgical Care, Ambulatory Care, Maternal/Child and Emergency departments. A convenience sample of 45 registered nurses from nine subspecialty groups was selected for a focus group interview and five focus groups were selected for a study population. Findings of exit interviews (from 1 September 2001 to 28 February 2002) were also included in the data analysis. These exit interviews of RNs were conducted by Nurse Recruiter at the time of their resignations. The data analysis showed that the most dissatisfying factors at work and within the work setting were identified as: high workload, stress associated with high workload, biased Nursing Management, lack of appreciation and monetary incentives, finally a rigid attitude of Nursing Management. However, the most satisfying factors were: working with an internationally reputable organization, patients' positive feedback and availability of required material or equipment. The study participants recommended that nursing retention could be improved at the Tertiary Care University Hospital by launching the following strategies by Nursing Management: reducing workload by adequate nurse-patient ratios according to international standards, promoting respect of nurses in front of patients and other staff, rewards and recognition of nurses, simplifying nursing documentation, increasing recreational activities for nurses and empowering nurses and Nursing Management group.
114 citations
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TL;DR: A multidisciplinary educational programme geared towards intensive care unit staff can successfully reduce the incidence rates of Ventilator-associated pneumonia.
113 citations
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TL;DR: Energy drink consumption is a health issue primarily of the adolescent and young adult male population and is linked to increased substance abuse and risk-taking behaviors, and the most common adverse events affect the cardiovascular and neurological systems.
Abstract: Purpose: With the rising consumption of so-called energy drinks over the last few years, there has been a growing body of literature describing significant adverse health events after the ingestion...
113 citations
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University of Münster1, German Cancer Research Center2, University Hospital Heidelberg3, University of Kiel4, University of Hamburg5, Stanford University6, University Hospital Regensburg7, Sapienza University of Rome8, Mayo Clinic9, Aga Khan University Hospital10, University of California, San Francisco11, University of Duisburg-Essen12, University of Alberta13, Charles University in Prague14, Semmelweis University15, Augsburg College16
TL;DR: Martin Hasselblatt1 · Christian Thomas1 · Volker Hovestadt2,3 · Daniel Schrimpf3,4,5 · Pascal Johann3,6,7 · Susanne Bens8 · Florian Oyen9· Susanne Peetz‐Dienhart1 · Yvonne Crede1 · Annika Wefers
Abstract: Martin Hasselblatt1 · Christian Thomas1 · Volker Hovestadt2,3 · Daniel Schrimpf3,4,5 · Pascal Johann3,6,7 · Susanne Bens8 · Florian Oyen9 · Susanne Peetz‐Dienhart1 · Yvonne Crede1 · Annika Wefers3,4,5 · Hannes Vogel10 · Markus J. Riemenschneider11 · Manila Antonelli12,13 · Felice Giangaspero12,13 · Marie Christine Bernardo14 · Caterina Giannini15 · Nasir Ud Din16 · Arie Perry17 · Kathy Keyvani18 · Frank van Landeghem19 · David Sumerauer20 · Peter Hauser21 · David Capper3,4,5 · Andrey Korshunov3,4,5 · David T. W. Jones3,6 · Stefan M. Pfister3,6,7 · Reinhard Schneppenheim9 · Reiner Siebert8 · Michael C. Frühwald22 · Marcel Kool3,6
112 citations
Authors
Showing all 3015 results
Name | H-index | Papers | Citations |
---|---|---|---|
Zulfiqar A Bhutta | 165 | 1231 | 169329 |
Khalid S. Khan | 92 | 684 | 33700 |
Danish Saleheen | 86 | 213 | 60659 |
Muhammad Riaz | 58 | 934 | 15927 |
Adil H. Haider | 58 | 408 | 12563 |
Marleen Temmerman | 56 | 276 | 16943 |
Tazeen H. Jafar | 56 | 190 | 26929 |
Abdul Waheed | 49 | 205 | 6057 |
Wasim Jafri | 45 | 262 | 11861 |
Muhammad Umar | 45 | 228 | 5851 |
Zohra S Lassi | 43 | 160 | 7186 |
Muneeb Ahmed | 41 | 137 | 6437 |
Saeed Hamid | 41 | 218 | 8360 |
Rumina Hasan | 39 | 184 | 5356 |
Sajjad Hussain | 39 | 517 | 7090 |