Institution
Ain Shams University
Education•Cairo, Egypt•
About: Ain Shams University is a education organization based out in Cairo, Egypt. It is known for research contribution in the topics: Population & Medicine. The organization has 23886 authors who have published 34493 publications receiving 444594 citations. The organization is also known as: ASU.
Topics: Population, Medicine, Thin film, Adsorption, Dielectric
Papers published on a yearly basis
Papers
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01 Jan 1984340 citations
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TL;DR: Point mutations in TGM1, the gene encoding transglutaminase 1, are identified in two of the multiplex LI families used in the linkage study and it is hypothesized that these mutations adversely affect formation of crosslinks essential in production of cornified cell envelopes and a normal stratum corneum layer of the skin.
Abstract: We recently mapped the disease locus for severe autosomal recessive lamellar ichthyosis (LI) to chromosome 14q11 and showed complete linkage with TGM1, the gene encoding transglutaminase 1. We have now identified point mutations in TGM1 in two of the multiplex LI families used in the linkage study. Each nucleotide change causes a non–conservative amino acid substitution of histidine for one of two adjacent arginine residues in exon 3 of the gene (Arg141His, Arg142His). Within the transglutaminase family, these arginines are invariant within a conserved region, distant from the catalytic site of the enzyme. We hypothesize that these mutations adversely affect formation of crosslinks essential in production of cornified cell envelopes and a normal stratum corneum layer of the skin.
340 citations
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TL;DR: The potential of proniosomes as stable precursors for the immediate preparation of niosomal carrier systems is suggested.
330 citations
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University of Porto1, Science for Life Laboratory2, Massachusetts Institute of Technology3, Norwich University4, Max Planck Society5, Swedish University of Agricultural Sciences6, Ain Shams University7, Wellcome Trust Sanger Institute8, European Bioinformatics Institute9, University of Cambridge10, Institut national de la recherche agronomique11, University of Bologna12, National Institutes of Health13, United States Department of Energy14, Spanish National Research Council15, University of Montana16, Texas A&M University17
TL;DR: It is proposed that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.
Abstract: The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.
328 citations
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TL;DR: A multi-period multi-echelon forward-reverse logistics network design under risk model is developed in a stochastic mixed integer linear programming (SMILP) decision making form as a multi-stage stochastically program to maximize the total expected profit.
328 citations
Authors
Showing all 24041 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hannes Jung | 159 | 2069 | 125069 |
Ajit Kumar Mohanty | 141 | 1124 | 93062 |
Chiara Mariotti | 141 | 1426 | 98157 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Guido Tonelli | 138 | 1458 | 97248 |
Ivica Puljak | 134 | 1436 | 97548 |
Roberto Chierici | 133 | 1207 | 85660 |
D. Del Re | 131 | 1406 | 87230 |
Andrea Venturi | 131 | 1336 | 90230 |
Plamen Iaydjiev | 131 | 1285 | 87958 |
Andrea Massironi | 129 | 1115 | 78457 |
Paolo Meridiani | 129 | 1200 | 81969 |
Csaba Hajdu | 129 | 1395 | 90105 |
Cesare Calabria | 128 | 1095 | 76784 |
C. A. Carrillo Montoya | 128 | 1033 | 78628 |