Institution
Atatürk University
Education•Erzurum, Turkey•
About: Atatürk University is a education organization based out in Erzurum, Turkey. It is known for research contribution in the topics: Population & Oxidative stress. The organization has 5710 authors who have published 14234 publications receiving 264334 citations. The organization is also known as: Atatürk Üniversitesi.
Topics: Population, Oxidative stress, Thin film, Antioxidant, Schottky diode
Papers published on a yearly basis
Papers
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TL;DR: The efficacy of these nanoparticles in sustaining the diclofenac sodium release profile was demonstrated and the release profiles and encapsulation efficiencies depended on the amount of Eudragit in the blend.
Abstract: The aim of this study was to formulate and characterize Eudragit® L100 and Eudragit® L100-poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing diclofenac sodium. Diclofenac generates severe adverse effects with risks of toxicity. Thus, nanoparticles were prepared to reduce these drawbacks in the present study. These nanoparticles were evaluated for surface morphology, particle size and size distribution, percentage drug entrapment, and in vitro drug release in pH 6.8. The prepared nanoparticles were almost spherical in shape, as determined by atomic force microscopy. The nanoparticles with varied size (241–274 nm) and 25.8–62% of entrapment efficiency were obtained. The nanoparticles formulations produced the release profiles with an initial burst effect in which diclofenac sodium release ranged between 38% and 47% within 4 h. The extent of drug release from Eudragit® L100 nanoparticles was up to 92% at 12 h. However, Eudragit®/PLGA nanoparticles showed an initial burst release followed by a slower sustained release. The cumulative release at 72 h was 56%, 69%, and 81% for Eudragit®/PLGA (20:80), Eudragit®/PLGA (30:70) and Eudragit®/PLGA (50:50) nanoparticles, respectively. The release profiles and encapsulation efficiencies depended on the amount of Eudragit in the blend. These data demonstrated the efficacy of these nanoparticles in sustaining the diclofenac sodium release profile.
118 citations
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TL;DR: The 3,4,5-trimethoxy and the 4-hydroxy derivatives showed interesting cytotoxic activities, which may be crucial for further anti-tumor activity studies, whereas some of these sulfonamides strongly inhibited both human (h) cytosolic isoforms hCA I and II.
Abstract: A series of new 4-(3-(4-substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides (7-12) was synthesized starting from 2-(4-substitutedbenzylidene)-2,3-dihydro-1H-inden-1-one (1-6) and 4-hydrazinobenzenesulfonamide. The substituted benzaldehydes from which the key intermediate was prepared by introducing 2- or 4-substituents such as fluorine, hydroxy, methoxy, or the 3,4,5-trimethoxy moieties. The compounds were tested for their cytotoxicity, tumor-specificity and potential as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The 3,4,5-trimethoxy and the 4-hydroxy derivatives showed interesting cytotoxic activities, which may be crucial for further anti-tumor activity studies, whereas some of these sulfonamides strongly inhibited both human (h) cytosolic isoforms hCA I and II.
117 citations
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TL;DR: The results showed that synthesised compounds (5, 13–16) demonstrated the best inhibition activity against hCA I and hCA II, and the compound 14 showed the highest inhibiton effect against h CA I.
Abstract: In this study, we have synthesised (3,4-dihydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone and a series of its derivatives (5, 13–16) and tested the ability of these compounds to inhibit two metalloenzyme human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, hCA I and hCA II. The synthesised compounds showed inhibitory effect on hCA I and hCA II isozymes. The results showed that synthesised compounds (5, 13–16) demonstrated the best inhibition activity against hCA I (IC50: 3.22–54.28 μM) and hCA II (IC50: 18.52–142.01 μM). The compound 14 showed the highest inhibiton effect against hCA I (IC50: 3.22 μM; Ki: 1.19 ± 1.4 μM). On the other hand, the compound 13 showed the highest inhibiton effect against hCA II (IC50: 18.52 μM; Ki: 3.25 ± 1.13 μM).
117 citations
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TL;DR: Discomfort during periodontal treatments, postoperative pain and postoperative dentin hypersensitivity were associated significantly with age, type of therapy and higher scores on Corah's Dental Anxiety Scale.
Abstract: Background The authors assessed the levels of postoperative pain, postoperative dentin hypersensitivity and discomfort patients experienced during various periodontal treatments by using a visual analog scale (VAS). They aimed to determine whether VAS scores could be predicted by patient's age and sex and to evaluate the factors associated with the pain. Subjects and Methods The study was carried out with 56 patients who had chronic periodontitis. Using a split-mouth design, the authors selected one quadrant in each patient and treated it with scaling and root planing (SRP). They treated other quadrants with the surgical therapies of modified Widman flap (MWF), flap with osseous resection (OF) and gingivectomy (GV), depending on the patient's diagnosis and treatment needs. They measured patients' discomfort during periodontal treatments, postoperative pain and postoperative dentin hypersensitivity by asking patients to mark a VAS. Results The authors' analysis showed no statistically significant differences between the patients' discomfort levels associated with the four therapy types during periodontal treatment. However, postoperative pain was significantly higher for OF ( P P Conclusions Discomfort during periodontal treatments, postoperative pain and postoperative dentin hypersensitivity were associated significantly with age, type of therapy and higher scores on Corah's Dental Anxiety Scale. Clinical Implications Periodontal treatment is experienced as painful by substantial numbers of patients. Therefore, the dentist should count the pain responses during and after treatment and estimate the degree of pain according to sex, age and therapy type.
117 citations
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TL;DR: Induced fit docking process performed on the compounds inhibiting hCA I, hCA II, AChE, and BChE receptors will be useful for design of more potent and selective inhibitors against the enzymes.
117 citations
Authors
Showing all 5909 results
Name | H-index | Papers | Citations |
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Mustafa Yilmaz | 95 | 751 | 45011 |
İlhami Gülçin | 92 | 397 | 30209 |
Ibrahim Karaman | 62 | 463 | 13059 |
Parham Taslimi | 51 | 180 | 6183 |
Ian H. White | 50 | 1005 | 12499 |
Sezai Ercisli | 47 | 478 | 8701 |
Şükrü Beydemir | 45 | 164 | 5944 |
Mehmet Kobya | 44 | 120 | 8968 |
Fikrettin Şahin | 44 | 204 | 9209 |
Metin Turan | 42 | 218 | 5474 |
Ali Cinar | 40 | 312 | 6330 |
Hakan Özkan | 40 | 148 | 7346 |
Mokhtar I. Yousef | 40 | 79 | 5828 |
Mehmet Yilmaz | 40 | 618 | 8292 |
Önder Metin | 38 | 111 | 5537 |