Institution
Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa
About: Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa is a based out in . It is known for research contribution in the topics: Supply chain & Sputtering. The organization has 874 authors who have published 863 publications receiving 20667 citations.
Papers published on a yearly basis
Papers
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TL;DR: Microplastics pose a threat to coastal environments due to their capacity to adsorb persistent organic pollutants (POPs) and further investigation is necessary to understand the relationship between plastic degradation and adsorption for different pollutants.
486 citations
TL;DR: In this article, carbon-isotope profiles from Toarcian fossil wood collected in England and Denmark have been shown to exhibit this large drop ( ∼− 7 ǫ )i nδ 13 C values, interpreted as due to an injection of isotopically light CO2 into the ocean-atmosphere system.
471 citations
TL;DR: This review provides for a concise overview of heterocyclic active compounds and families and their main applications in medicine, focusing on those suitable for cancer therapy while simultaneously addressing main biochemical modes of action, biological targets, structure-activity relationships as well as intrinsic limitation issues in the use of these compounds.
Abstract: The majority of heterocycle compounds and typically common heterocycle fragments present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility and unique physicochemical properties, have poised them as true cornerstones of medicinal chemistry. Apart from the already marketed drugs, there are many other being investigated for their promising activity against several malignancies. In particular, anticancer research has been capitalizing on the intrinsic versatility and dynamic core scaffold of these compounds. Nevertheless, as for any other promising anticancer drugs, heterocyclic compounds do not come without shortcomings. In this review, we provide for a concise overview of heterocyclic active compounds and families and their main applications in medicine. We shall focus on those suitable for cancer therapy while simultaneously addressing main biochemical modes of action, biological targets, structure-activity relationships as well as intrinsic limitation issues in the use of these compounds. Finally, considering the advent of nanotechnology for effective selective targeting of drugs, we shall discuss fundamental aspects and considerations on nanovectorization of such compounds that may improve pharmacokinetic/pharmacodynamic properties of heterocycles.
399 citations
TL;DR: The paper presents a supply chain simulation study for a real case concerned with the Portuguese automotive supply chain, evaluating alternative supply chain scenarios for improving supply chain resilience to a disturbance and understanding how mitigation strategies affect each supply chain entity performance.
382 citations
TL;DR: It is reported for the first time the presence of this pollutant in fish populations from the Mondego estuary raising concerns on their potential negative effects.
349 citations
Authors
Showing all 874 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Silvio Aime | 79 | 773 | 26976 |
| Elvira Fortunato | 74 | 866 | 26731 |
| Rodrigo Martins | 74 | 855 | 24984 |
| Andre E. Merbach | 70 | 412 | 17749 |
| Maria A.M. Reis | 65 | 358 | 16343 |
| José J. G. Moura | 63 | 465 | 15490 |
| Hermínia de Lencastre | 62 | 187 | 13297 |
| Helena Freitas | 61 | 249 | 16615 |
| Isabel Moura | 61 | 420 | 13481 |
| João Carlos Marques | 60 | 407 | 12928 |
| Isabel M.P.L.V.O. Ferreira | 58 | 479 | 11982 |
| Carlos A. M. Afonso | 57 | 413 | 13891 |
| Manuel J.T. Carrondo | 54 | 281 | 9787 |
| Mauro Botta | 52 | 268 | 10432 |
| Isabel Fonseca | 51 | 402 | 10329 |