Institution
Florida State University College of Arts and Sciences
About: Florida State University College of Arts and Sciences is a based out in . It is known for research contribution in the topics: Population & Context (language use). The organization has 10947 authors who have published 13209 publications receiving 291678 citations.
Papers published on a yearly basis
Papers
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TL;DR: A new statistical method for estimating divergence dates of species from DNA sequence data by a molecular clock approach is developed, and this dating may pose a problem for the widely believed hypothesis that the bipedal creatureAustralopithecus afarensis, which lived some 3.7 million years ago, was ancestral to man and evolved after the human-ape splitting.
Abstract: A new statistical method for estimating divergence dates of species from DNA sequence data by a molecular clock approach is developed. This method takes into account effectively the information contained in a set of DNA sequence data. The molecular clock of mitochondrial DNA (mtDNA) was calibrated by setting the date of divergence between primates and ungulates at the Cretaceous-Tertiary boundary (65 million years ago), when the extinction of dinosaurs occurred. A generalized least-squares method was applied in fitting a model to mtDNA sequence data, and the clock gave dates of 92.3 +/- 11.7, 13.3 +/- 1.5, 10.9 +/- 1.2, 3.7 +/- 0.6, and 2.7 +/- 0.6 million years ago (where the second of each pair of numbers is the standard deviation) for the separation of mouse, gibbon, orangutan, gorilla, and chimpanzee, respectively, from the line leading to humans. Although there is some uncertainty in the clock, this dating may pose a problem for the widely believed hypothesis that the pipedal creature Australopithecus afarensis, which lived some 3.7 million years ago at Laetoli in Tanzania and at Hadar in Ethiopia, was ancestral to man and evolved after the human-ape splitting. Another likelier possibility is that mtDNA was transferred through hybridization between a proto-human and a proto-chimpanzee after the former had developed bipedalism.
8,124 citations
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Cold Spring Harbor Laboratory1, California Institute of Technology2, University of California, Irvine3, Florida State University College of Arts and Sciences4, Yale University5, Wellcome Trust Sanger Institute6, Norwegian University of Science and Technology7, Affymetrix8, University of North Carolina at Chapel Hill9, University of Lausanne10, University of Geneva11, Genome Institute of Singapore12, Stanford University13, Pompeu Fabra University14
TL;DR: Evidence that three-quarters of the human genome is capable of being transcribed is reported, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs that prompt a redefinition of the concept of a gene.
Abstract: Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.
4,450 citations
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TL;DR: The symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease are highlighted.
4,065 citations
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TL;DR: This review will attempt to address several key questions related to the use of ROS as signaling molecules in cells, including the dynamics and specificity of ROS signaling, networking of ROS with other signaling pathways, ROS signaling within and across different cells, ROS waves and the evolution of the ROS gene network.
1,879 citations
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TL;DR: This Opinion focuses on the possibility that ROS are beneficial to plants, supporting cellular proliferation, physiological function, and viability, and that maintaining a basal level of ROS in cells is essential for life.
1,828 citations
Authors
Showing all 10947 results
Name | H-index | Papers | Citations |
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Ralph B. D'Agostino | 226 | 1287 | 229636 |
Joseph Wang | 158 | 1282 | 98799 |
Roy F. Baumeister | 157 | 650 | 132987 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
Adrian Bauman | 127 | 1061 | 91151 |
Arnold I. Caplan | 123 | 506 | 70605 |
Omar K. Farha | 123 | 618 | 63896 |
Ken'ichi Nomoto | 122 | 675 | 52000 |
Andrew H. Paterson | 119 | 496 | 59373 |
Jian Liu | 117 | 2090 | 73156 |
Liyuan Han | 114 | 766 | 65277 |
Jon H. Kaas | 111 | 526 | 46192 |
Jordan Grafman | 109 | 546 | 54241 |
Yoshinori Ohsumi | 109 | 267 | 66470 |
Howard Eichenbaum | 108 | 279 | 44172 |