Institution
Free University of Brussels
About: Free University of Brussels is a based out in . It is known for research contribution in the topics: Population & Pancreatic islets. The organization has 6553 authors who have published 8188 publications receiving 325555 citations.
Topics: Population, Pancreatic islets, Insulin, Receptor, Intensive care
Papers published on a yearly basis
Papers
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TL;DR: This is the first direct detection of gravitational waves and the first observation of a binary black hole merger, and these observations demonstrate the existence of binary stellar-mass black hole systems.
Abstract: On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-Wave Observatory simultaneously observed a transient gravitational-wave signal. The signal sweeps upwards in frequency from 35 to 250 Hz with a peak gravitational-wave strain of $1.0 \times 10^{-21}$. It matches the waveform predicted by general relativity for the inspiral and merger of a pair of black holes and the ringdown of the resulting single black hole. The signal was observed with a matched-filter signal-to-noise ratio of 24 and a false alarm rate estimated to be less than 1 event per 203 000 years, equivalent to a significance greater than 5.1 {\sigma}. The source lies at a luminosity distance of $410^{+160}_{-180}$ Mpc corresponding to a redshift $z = 0.09^{+0.03}_{-0.04}$. In the source frame, the initial black hole masses are $36^{+5}_{-4} M_\odot$ and $29^{+4}_{-4} M_\odot$, and the final black hole mass is $62^{+4}_{-4} M_\odot$, with $3.0^{+0.5}_{-0.5} M_\odot c^2$ radiated in gravitational waves. All uncertainties define 90% credible intervals.These observations demonstrate the existence of binary stellar-mass black hole systems. This is the first direct detection of gravitational waves and the first observation of a binary black hole merger.
9,596 citations
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Wellcome Trust Centre for Human Genetics1, University of Liège2, University of Chicago3, Yale University4, University of Pittsburgh5, Montreal Heart Institute6, Massachusetts Institute of Technology7, Johns Hopkins University8, University of Toronto9, Cedars-Sinai Medical Center10, McGill University11, Harvard University12, Ghent University Hospital13, Katholieke Universiteit Leuven14, Free University of Brussels15, Paris Diderot University16, Western General Hospital17, King's College London18, University of Oxford19, Wellcome Trust Sanger Institute20, University of Cambridge21, Newcastle University22
TL;DR: The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1, which offer promise for informed therapeutic development.
Abstract: Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
2,584 citations
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TL;DR: This large pan-European study documents the high frequency of sepsis in critically ill patients and shows a close relationship between the proportion of patients with sepsi and the intensive care unit mortality in the various countries.
Abstract: Objective:To better define the incidence of sepsis and the characteristics of critically ill patients in European intensive care units.Design:Cohort, multiple-center, observational study.Setting:One hundred and ninety-eight intensive care units in 24 European countries.Patients:All new adult admissi
2,495 citations
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TL;DR: In this article, a valued outranking graph is constructed by using a preference index, and two possibilities are considered to solve the ranking problem by using this valued graph: PROMETHEE I provides a partial preorder and PROMTHEE II a total preorder on the set of the possible actions.
Abstract: Principles for a new family of outranking methods are given. The main aim of the proposed PROMETHEE approach is to be as easily understood as possible by the decision-maker. It is based on extensions of the notion of criterion. Six possible extensions are considered. These extensions can easily be identified by the decision-maker because the parameters to be defined at most 2 have an economic significance. A valued outranking graph is constructed by using a preference index. Two possibilities are considered to solve the ranking problem by using this valued graph. PROMETHEE I provides a partial preorder and PROMETHEE II a total preorder on the set of the possible actions.
2,244 citations
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TL;DR: The results suggest that EZH2 serves as a recruitment platform for DNA methyltransferases, thus highlighting a previously unrecognized direct connection between two key epigenetic repression systems.
Abstract: The establishment and maintenance of epigenetic gene silencing is fundamental to cell determination and function. The essential epigenetic systems involved in heritable repression of gene activity are the Polycomb group (PcG) proteins and the DNA methylation systems. Here we show that the corresponding silencing pathways are mechanistically linked. We find that the PcG protein EZH2 (Enhancer of Zeste homolog 2) interacts-within the context of the Polycomb repressive complexes 2 and 3 (PRC2/3)-with DNA methyltransferases (DNMTs) and associates with DNMT activity in vivo. Chromatin immunoprecipitations indicate that binding of DNMTs to several EZH2-repressed genes depends on the presence of EZH2. Furthermore, we show by bisulphite genomic sequencing that EZH2 is required for DNA methylation of EZH2-target promoters. Our results suggest that EZH2 serves as a recruitment platform for DNA methyltransferases, thus highlighting a previously unrecognized direct connection between two key epigenetic repression systems.
1,976 citations
Authors
Showing all 6553 results
Name | H-index | Papers | Citations |
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Jean Louis Vincent | 161 | 1667 | 163721 |
Roberto Romero | 151 | 1516 | 108321 |
Marco Costa | 146 | 1458 | 105096 |
Andrew Steptoe | 137 | 1003 | 73431 |
Joël Vandekerckhove | 107 | 452 | 38241 |
Pierre Friedlingstein | 105 | 285 | 69536 |
Marc Parmentier | 105 | 349 | 40833 |
M. Van Montagu | 105 | 300 | 37522 |
Irwin J. Kopin | 105 | 627 | 40141 |
Paul Devroey | 104 | 526 | 39887 |
Martine Piccart | 103 | 613 | 50072 |
Chantal Mathieu | 102 | 753 | 43596 |
Gilbert Vassart | 101 | 458 | 41430 |
Philippe Dubois | 101 | 1098 | 48086 |
Günter Klöppel | 93 | 348 | 27963 |