Institution
Liaquat National Hospital
Healthcare•Karachi, Pakistan•
About: Liaquat National Hospital is a healthcare organization based out in Karachi, Pakistan. It is known for research contribution in the topics: Population & Medicine. The organization has 636 authors who have published 717 publications receiving 6277 citations. The organization is also known as: Liaquat National Hospital & Medical College & LNH.
Topics: Population, Medicine, Breast cancer, Health care, Diabetes mellitus
Papers published on a yearly basis
Papers
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TL;DR: The frequencies of resistance of Staphylococcus aureus isolates to methicillin (MRSA), Klebsiella pneumoniae to ceftazidime or ceftriaxone, Acinetobacter baumannii to imipenem, and Pseudomonas aeruginosa to piperacillin were far higher in the consortium's ICUs than in comparable US ICUs.
506 citations
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TL;DR: During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, prospective data was gathered from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days.
446 citations
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TL;DR: TSI is a major source of morbidity and mortality throughout the world and largely preventable mechanisms, including road traffic accidents and falls, are the main causes of TSI globally.
298 citations
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University of Pennsylvania1, Harvard University2, Broad Institute3, Samsung Medical Center4, Boston Children's Hospital5, Punjab Institute of Cardiology6, Karachi Institute of Heart Diseases7, Civil Hospital Karachi8, Liaquat National Hospital9, Icahn School of Medicine at Mount Sinai10, Children's Hospital Oakland Research Institute11, University of Cambridge12, Wellcome Trust Sanger Institute13
TL;DR: Overall, these observations provide a roadmap for a ‘human knockout project’, a systematic effort to understand the phenotypic consequences of complete disruption of genes in humans.
Abstract: A major goal of biomedicine is to understand the function of every gene in the human genome. Loss-of-function mutations can disrupt both copies of a given gene in humans and phenotypic analysis of such 'human knockouts' can provide insight into gene function. Consanguineous unions are more likely to result in offspring carrying homozygous loss-of-function mutations. In Pakistan, consanguinity rates are notably high. Here we sequence the protein-coding regions of 10,503 adult participants in the Pakistan Risk of Myocardial Infarction Study (PROMIS), designed to understand the determinants of cardiometabolic diseases in individuals from South Asia. We identified individuals carrying homozygous predicted loss-of-function (pLoF) mutations, and performed phenotypic analysis involving more than 200 biochemical and disease traits. We enumerated 49,138 rare (<1% minor allele frequency) pLoF mutations. These pLoF mutations are estimated to knock out 1,317 genes, each in at least one participant. Homozygosity for pLoF mutations at PLA2G7 was associated with absent enzymatic activity of soluble lipoprotein-associated phospholipase A2; at CYP2F1, with higher plasma interleukin-8 concentrations; at TREH, with lower concentrations of apoB-containing lipoprotein subfractions; at either A3GALT2 or NRG4, with markedly reduced plasma insulin C-peptide concentrations; and at SLC9A3R1, with mediators of calcium and phosphate signalling. Heterozygous deficiency of APOC3 has been shown to protect against coronary heart disease; we identified APOC3 homozygous pLoF carriers in our cohort. We recruited these human knockouts and challenged them with an oral fat load. Compared with family members lacking the mutation, individuals with APOC3 knocked out displayed marked blunting of the usual post-prandial rise in plasma triglycerides. Overall, these observations provide a roadmap for a 'human knockout project', a systematic effort to understand the phenotypic consequences of complete disruption of genes in humans.
268 citations
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TL;DR: The preserved association of LDL-C with risk of AMI among Asians, despite the lower baseline levels, suggests the need to rethink treatment thresholds and targets in this population and suggests the low HDL-C level among South Asians requires further study and targeted intervention.
198 citations
Authors
Showing all 638 results
Name | H-index | Papers | Citations |
---|---|---|---|
Mohammad Wasay | 33 | 185 | 3930 |
Naveen Faridi | 20 | 81 | 1098 |
Sadia Sultan | 17 | 104 | 954 |
Muhammad Muzzammil Edhi | 16 | 52 | 659 |
Atif Ali Hashmi | 15 | 91 | 709 |
Anwarul Haque | 14 | 53 | 493 |
Ping Yang | 14 | 77 | 589 |
Shaukat A. Brah | 13 | 19 | 1537 |
Muhammad Irfan | 12 | 56 | 299 |
Salman Sharif | 11 | 64 | 527 |
Sadiq S. Rehmani | 11 | 29 | 317 |
Altaf Ahmed | 10 | 19 | 1430 |
Faiz Y. Bhora | 10 | 30 | 287 |
Omer Khalil Ahmed | 10 | 46 | 330 |
Amna Khurshid | 10 | 13 | 278 |