Los Alamos National Laboratory

About: Los Alamos National Laboratory is a facility organization based out in Los Alamos, New Mexico, United States. It is known for research contribution in the topics: Neutron & Laser. The organization has 31079 authors who have published 74688 publications receiving 2999590 citations. The organization is also known as: LANL & Project Y.

Ecohydrology of water-limited environments: A scientific vision

Abstract: [1] Water-limited environments occupy about half of the Earth's land surface and contain some of the fastest growing population centers in the world. Scarcity or variable distributions of water and nutrients make these environments highly sensitive to change. Given the importance of water-limited environments and the impacts of increasing demands on water supplies and other natural resources, this paper highlights important societal problems and scientific challenges germane to these environments and presents a vision on how to accelerate progress. We argue that improvements in our fundamental understanding of the links between hydrological, biogeochemical, and ecological processes are needed, and the way to accomplish this is by fostering integrated, interdisciplinary approaches to problem solving and hypothesis testing through place-based science. Such an ecohydrological approach will create opportunities to develop new methodologies and ways of thinking about these complex environmental systems and help us improve forecasts of environmental change.

A Variational Approach to Reconstructing Images Corrupted by Poisson Noise

Abstract: We propose a new variational model to denoise an image corrupted by Poisson noise. Like the ROF model described in [1] and [2], the new model uses total-variation regularization, which preserves edges. Unlike the ROF model, our model uses a data-fidelity term that is suitable for Poisson noise. The result is that the strength of the regularization is signal dependent, precisely like Poisson noise. Noise of varying scales will be removed by our model, while preserving low-contrast features in regions of low intensity.

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

Abstract: Recent findings intriguingly place DNA double-strand break repair proteins at chromosome ends in yeast, where they help maintain normal telomere length and structure. In the present study, an essential telomere function, the ability to cap and thereby protect chromosomes from end-to-end fusions, was assessed in repair-deficient mouse cell lines. By using fluorescence in situ hybridization with a probe to telomeric DNA, spontaneously occurring chromosome aberrations were examined for telomere signal at the points of fusion, a clear indication of impaired end-capping. Telomeric fusions were not observed in any of the repair-proficient controls and occurred only rarely in a p53 null mutant. In striking contrast, chromosomal end fusions that retained telomeric sequence were observed in nontransformed DNA-PKcs-deficient cells, where they were a major source of chromosomal instability. Metacentric chromosomes created by telomeric fusion became even more abundant in these cells after spontaneous immortalization. Restoration of repair proficiency through transfection with a functional cDNA copy of the human DNA-PKcs gene reduced the number of fusions compared with a negative transfection control. Virally transformed cells derived from Ku70 and Ku80 knockout mice also displayed end-to-end fusions. These studies demonstrate that DNA double-strand break repair genes play a dual role in maintaining chromosomal stability in mammalian cells, the known role in repairing incidental DNA damage, as well as a new protective role in telomeric end-capping.