Institution
McLean Hospital
Healthcare•Belmont, Massachusetts, United States•
About: McLean Hospital is a healthcare organization based out in Belmont, Massachusetts, United States. It is known for research contribution in the topics: Bipolar disorder & Population. The organization has 2344 authors who have published 4103 publications receiving 205691 citations. The organization is also known as: Somerville Asylum & Charlestown Asylum.
Papers published on a yearly basis
Papers
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TL;DR: It is argued that the global burden of mental illness is underestimated and the reasons for under-estimation are examined to identify five main causes: overlap between psychiatric and neurological disorders; the grouping of suicide and self-harm as a separate category; conflation of all chronic pain syndromes with musculoskeletal disorders; exclusion of personality disorders from disease burden calculations; and inadequate consideration of the contribution of severe mental illness to mortality from associated causes.
1,444 citations
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TL;DR: This work unequivocally identified autophagosomes and other prelysosomal autophagic vacuoles (AVs), which were morphologically and biochemically similar to AVs highly purified from mouse liver, and provides the first evidence that macroautophagy is extensively involved in the neurodegenerative/regenerative process in AD.
Abstract: The accumulation of lysosomes and their hydrolases within neurons is a well-established neuropathologic feature of Alzheimer disease (AD). Here we show that lysosomal pathology in AD brain involves extensive alterations of macroautophagy, an inducible pathway for the turnover of intracellular constituents, including organelles. Using immunogold labeling with compartmental markers and electron microscopy on neocortical biopsies from AD brain, we unequivocally identified autophagosomes and other prelysosomal autophagic vacuoles (AVs), which were morphologically and biochemically similar to AVs highly purified from mouse liver. AVs were uncommon in brains devoid of AD pathology but were abundant in AD brains particularly, within neuritic processes, including synaptic terminals. In dystrophic neurites, autophagosomes, multivesicular bodies, multilamellar bodies, and cathepsin-containing autophagolysosomes were the predominant organelles and accumulated in large numbers. These compartments were distinguishable from lysosomes and lysosomal dense bodies, previously shown also to be abundant in dystrophic neurites. Autophagy was evident in the perikarya of affected neurons, particularly in those with neurofibrillary pathology where it was associated with a relative depletion of mitochondria and other organelles. These observations provide the first evidence that macroautophagy is extensively involved in the neurodegenerative/regenerative process in AD. The striking accumulations of immature AV forms in dystrophic neurites suggest that the transport of AVs and their maturation to lysosomes may be impaired, thereby impeding the suspected neuroprotective functions of autophagy.
1,385 citations
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TL;DR: The neurobiological sequelae of early stress and maltreatment may play a significant role in the emergence of psychiatric disorders during development.
1,306 citations
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TL;DR: Findings support the hypothesis that fear extinction is impaired in PTSD and suggest that dysfunctional activation in brain structures that mediate fear extinction learning, and especially its recall, underlie this impairment.
1,161 citations
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TL;DR: Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.
1,063 citations
Authors
Showing all 2369 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Kessler | 274 | 1332 | 328983 |
Joseph Biederman | 179 | 1012 | 117440 |
Eric J. Nestler | 178 | 748 | 116947 |
Dennis J. Selkoe | 177 | 607 | 145825 |
Carl W. Cotman | 165 | 809 | 105323 |
Ming T. Tsuang | 140 | 885 | 73865 |
M. Flint Beal | 135 | 461 | 64232 |
Scott L. Rauch | 130 | 430 | 64573 |
Joseph V. Bonventre | 126 | 596 | 61009 |
Robert W. McCarley | 120 | 584 | 61051 |
Eduard Vieta | 119 | 1248 | 57755 |
Paul E. Keck | 117 | 469 | 44869 |
Susan L. McElroy | 117 | 570 | 44992 |
Joseph T. Coyle | 116 | 555 | 63157 |
Ross J. Baldessarini | 114 | 850 | 48148 |