Middlesex University

About: Middlesex University is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Context (language use) & Population. The organization has 4203 authors who have published 10964 publications receiving 247580 citations.

Leaders without ethics in global business: corporate psychopaths

Abstract: This paper introduces the concept of Corporate Psychopaths as ruthless employees who can successfully gain entry to organizations and can then get promoted within those organizations to reach senior managerial and leadership positions. What little empirical research currently exists supports the view that Corporate Psychopaths are more commonly found at senior levels of organizations. This paper presents further empirical evidence that supports this view. It discusses how, in a quantitative sample of 346 white-collar workers, in 2008, research using a psychopathy scale identified greater levels of psychopathy at more senior levels of corporations than at more junior levels. The paper goes on to propose that this is a universal issue that can pose various ethical problems for corporations because of the ruthless, selfish and conscience-free approach to life that Corporate Psychopaths have. Other ethical issues are to do with their moral accountability and with the problems associated with the possibility of screening employees for psychopathy. The paper reviews the literature on psychopathy and concludes that while psychopaths appear to be universal in occurrence, they may well be environmentally limited in their possible actions in more collectivist societies. However, the global spread of western, individualistically oriented corporations may pose a threat to any collectivist societies in which they operate. Copyright © 2010 John Wiley & Sons, Ltd.

Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients

Abstract: Purpose: The use of tumor-derived proteins as cancer vaccines is complicated by tolerance to these self-antigens. Tolerance may be broken by immunization with activated, autologous, ex vivo generated and antigen-loaded, antigen-presenting cells (APC); however, targeting tumor antigen directly to APC in vivo would be a less complicated strategy. We wished to test whether targeted delivery of an otherwise poorly immunogenic, soluble antigen to APC through their mannose receptors (MR) would induce clinically relevant immunity. Experimental Design: Two phase I studies were conducted with CDX-1307, a vaccine composed of human chorionic gonadotropin beta-chain (hCG-β) fused to an MR-specific monoclonal antibody, administered either locally (intradermally) or systemically (intravenously) in patients with advanced epithelial malignancies. An initial dose escalation of single-agent CDX-1307 was followed by additional cohorts of CDX-1307 combined with granulocyte-macrophage colony-stimulating factor (GM-CSF) and the Toll-like receptor (TLR) 3 agonist polyinosinic-polycytidylic acid (poly-ICLC) and TLR7/8 agonist resiquimod to activate the APC. Results: CDX-1307 induced consistent humoral and T-cell responses to hCG-β when coadministered with TLR agonists. Greater immune responses and clinical benefit, including the longest duration of stable disease, were observed with immunization combined with local TLR agonists. Immune responses were induced equally efficiently in patients with elevated and nonelevated levels of serum hCG-β. Antibodies within the serum of vaccinated participants had tumor suppressive function in vitro . Toxicity consisted chiefly of mild injection site reactions. Conclusions: APC targeting and activation induce adaptive immunity against poorly immunogenic self-antigens which has implications for enhancing the efficacy of cancer immunotherapy. Clin Cancer Res; 17(14); 4844–53. ©2011 AACR .

Population superdiversity and new migrant enterprise: The case of London

Abstract: This article aims to contribute towards an improved empirical and conceptual understanding of the recent dramatic growth in migrant enterprises within London. Taking as its starting point the emergence of increasingly diverse populations within many urban and regional contexts, the article draws upon the concept of ‘superdiversity’ to develop a contextual analysis of the development of new migrant enterprise. In the absence of existing data, the research method combines secondary materials with primary observational and interview data in relation to six new arrival communities. The results provide a description of the changing context for migrant business within London, mapping the emergence of new forms and geographies of enterprise. The analysis is developed through an examination of processes of business start up and growth, and integration into institutional and regulatory frameworks, to demonstrate how elements of ethnicity, migratory status and a range of other variables interplay with wider economi...

The modern scientist-practitioner : a guide to practice in psychology

Abstract: Lunt, Foreword. Introduction, What Does it Mean to be a Scientist-Practitioner? Working Towards a New Vision. Acquiring the Art of Reasoning: Straddling the Worlds of Rigour and Meaning. Arriving at Shared Psychological Narratives: Formulation and Explanation. Innovation and Improvization: The Unacknowledged World of the Creative Scientist-Practitioner. What Kind of Scientists Are We? Re-examining the Nature of Scientific Knowledge. Developing an Identity as a Scientist-Practitioner: Defining Who we Are. Miller, Frederickson, Generalizable Findings and Idiographic Problems: Struggles and Successes for Educational Psychologists as Scientist-Practitioners. Bury, Strauss, The Scientist-Practitioner in a Counselling Psychology Setting. Haarbosch, Newey, Feeling One's Way in the Dark: Applying the Scientist-Practitioner Model in an Emerging Field. Cavanagh, Grant, Coaching Psychology and the Scientist-Practitioner Model. Kwaitowski, Winter, Roots, Relativity and Realism: The Occupational Psychologist as Scientist-Practitioner. Bono, The Scientist-Practitioner as Thinker: A Comment on Judgement and Design. Learning for Tomorrow: Professional Survival in an Uncertain World. Conclusion: The Scientist-Practitioner Model: A New Vision.