Military Medical Academy

About: Military Medical Academy is a healthcare organization based out in Belgrade, Serbia. It is known for research contribution in the topics: Population & Poison control. The organization has 6865 authors who have published 9615 publications receiving 153086 citations. The organization is also known as: Vojnomedicinska Akademija.

Rapid Canine Distalization Using Distraction of the Periodontal Ligament: A Preliminary Clinical Validation of the Original Technique

Abstract: The process of rapid canine distalization through the distraction of the periodontal ligament is similar to the process in the midpalatal suture during rapid palatal expansion. Rapid canine distalization can be achieved in three weeks with this technique. The aim of this research was to evaluate the effects of rapid canine distalization on dentoalveolar tissues during the rapid distalization of canine teeth with semirigid, individual tooth-borne distractors. The study was carried out on 43 canine teeth in 18 (seven male and 11 female) patients who required first premolar extractions. The mean age of the patients was 16.7 years. The second premolars and first molars were used as anchor units. Orthodontic models, cephalometric and panoramic radiographs, and standard photographs of all the patients were taken before treatment and after the consolidation period. Periapical radiographies of the canines and anchor units were obtained once a week during the distalization period. The distractors were activated 0.25 mm three times a day, and the canines were distalized efficiently an average of three weeks. The within-group differences were evaluated with the Wilcoxon test. The maxillary canines were distalized an average of 5.76 mm with 11.47 degrees distal tipping. The maxillary first molars moved mesially 0.56 mm and extruded 0.64 mm. The maxillary incisors showed 1.44 degrees of palatal tipping. The mean distal movement of the mandibular canines was 3.5 mm with 7.16 degrees distal tipping. Anchorage loss was not observed in the mandibular first molars.

Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity

Abstract: Galectin-3, a β galactoside–binding lectin, plays an important role in the processes relevant to tumorigenesis such as malignant cell transformation, invasion and metastasis. We have investigated whether deletion of Galectin-3 in the host affects the metastasis of B16F1 malignant melanoma. Galectin-3-deficient (Gal-3−/−) mice are more resistant to metastatic malignant melanoma as evaluated by number and size of metastatic colonies in the lung. In vitro assays showed lower number of attached malignant cells in the tissue section derived from Gal-3−/− mice. Furthermore, lack of Galectin-3 correlates with higher serum levels of IFN-γ and IL-17 in tumor bearing hosts. Interestingly, spleens of Gal-3−/− mice have lower number of Foxp3+ T cells after injection of B16F1 melanoma cells. Finally, we found that while CD8+ T cell and adherent cell cytotoxicity were similar, there was greater cytotoxic activity of splenic NK cells of Gal-3−/− mice compared with “wild-type” (Gal-3 +/+ ) mice. Despite the reduction in total number of CD3e−NK1.1+, Gal-3−/− mice constitutively have a significantly higher percentage of effective cytotoxic CD27highCD11bhigh NK cells as well as the percentage of immature CD27highCD11blow NK cells. In contrast, CD27lowCD11bhigh less functionally exhausted NK cells and NK cells bearing inhibitory KLRG1 receptor were more numerous in Gal-3 +/+ mice. It appears that lack of Galectin-3 affects tumor metastasis by at least two independent mechanisms: by a decrease in binding of melanoma cells onto target tissue and by enhanced NK-mediated anti-tumor response suggesting that Galectin-3 may be considered as therapeutic target.

Iodine-131 treatment and high-resolution CT: results in patients with lung metastases from differentiated thyroid carcinoma.

Abstract: Between 1984 and 2002, pulmonary metastases were detected in 42 (4%) out of 1,023 patients with differentiated thyroid carcinoma (DTC) in our department. The age at diagnosis ranged from 6 to 77 years. Lung metastases were diagnosed by both increased thyroglobulin (Tg) levels and positive uptake of iodine-131 on scans, and/or positive radiological findings. The primary tumours were histologically classified as papillary (30 patients), follicular (nine patients) and poorly differentiated (two tall cell, one insular carcinoma). The duration of follow-up ranged from 24 to 228 months. The end-results of the 131I therapy were evaluated. The treatment of choice was 131I therapy of metastases after total thyroidectomy plus lymph node dissection (if lymph node metastases were present). Applied single and total 131I activities were 1.8–10.4 GBq and 5.5–43.7 GBq, respectively. Lung metastases were present at the time of diagnosis in 30 patients and developed during the follow-up period in the remaining 12. Twelve patients with extensive metastases died of thyroid carcinoma and another died due to secondary malignancy (malignant mesothelioma). Ten patients with lung metastases remain completely free of disease and are probably cured, while another seven were stable at the time of study. Three- and five-year survival rates were 86% (36/42) and 76% (32/42), respectively. To define the diagnostic value of high-resolution computed tomography (HRCT) and identify the distinctive features of lung metastases from DTC, 22 patients were further examined with HRCT within 2 weeks of the initial diagnosis of lung metastases and the results were compared with chest X-ray findings. HRCT detected metastases in 10 out of 14 patients with a normal chest X-ray and confirmed metastases in all patients with positive (n=5) and suspicious (n=3) chest X-ray. HRCT did not show any abnormalities in four patients with positive lung uptake on 131I whole-body images. Stage of disease, existence of distance metastases other than to the lung, and HRCT characteristics were significant prognostic variables. Lung metastases from DTC can be cured with 131I therapy in a considerable number of patients, especially when they are not associated with other distant metastases; they should therefore be treated at an early stage. HRCT clearly improved diagnostic ability in the evaluation of lung metastases compared with chest X-ray and should be the primary method when radiological correlation is needed. The main, and new, finding of the study is that HRCT not only improves diagnostic ability but is also of prognostic value.

Ocular Trauma Score in childhood open-globe injuries.

Abstract: BACKGROUND: To assess prognostic value of the Ocular Trauma Score (OTS) in childhood open-globe injuries. METHODS: This retrospective, interventional case series included 61 children with open-globe injuries. Certain numerical values rendered to the OTS variables (visual acuity, rupture, endophthalmitis, perforating injury, retinal detachment, afferent pupillary defect) at presentation were summated and converted into OTS categories; the likelihood of the final visual acuities in the OTS categories were calculated, and compared with those in the OTS Study. RESULTS: Age ranged from 3 years to 14 years (mean, 8.0 years). Forty-two boys and 19 girls were included. Follow-up ranged from 6 months to 56 months (mean, 18 months). The likelihood of the final visual acuities (no light perception, light perception/hand motion, 1/200-19/200, 20/200-20/50, and > or = 20/40) in the OTS categories (1 through 5) in this group were similar to those in the OTS Study group. CONCLUSIONS: OTS calculated at initial examination may provide prognostic information in children with open-globe injuries. Language: en