Institution
Nycomed
About: Nycomed is a based out in . It is known for research contribution in the topics: Iodixanol & Roflumilast. The organization has 1811 authors who have published 1505 publications receiving 39061 citations. The organization is also known as: Nycomed International Management GmbH.
Topics: Iodixanol, Roflumilast, Iohexol, Magnetic resonance imaging, Gadodiamide
Papers published on a yearly basis
Papers
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TL;DR: This investigation investigated whether roflumilast would reduce the frequency of exacerbations requiring corticosteroids in patients with COPD and found that targeted specific therapies could improve disease management.
748 citations
TL;DR: MRI and ultrasound are valuable diagnostic methods in patients with arthritis who have normal findings on radiologic evaluation and found ultrasound to be even more sensitive than MRI in the detection of synovitis.
Abstract: Objective
A prospective study was performed comparing conventional radiography, 3-phase bone scintigraphy, ultrasound, and magnetic resonance imaging (MRI) with precontrast and dynamic postcontrast examinations in 60 patients with various forms of arthritis including rheumatoid arthritis (RA), spondylarthropathy, and arthritis associated with connective tissue disease.
Methods
A total of 840 finger joints were examined clinically and by all 4 imaging methods. Experienced investigators blinded to the clinical findings and diagnoses analyzed all methods independently of each other. The patients were divided into 2 groups. Group 1 included 32 patients (448 finger joints) without radiologic signs of destructive arthritis (Larsen grades 0–1) of the evaluated hand and wrist and group 2 included 28 patients (392 finger joints) with radiographs revealing erosions (Larsen grade 2) of the evaluated hand and/or wrist.
Results
Clinical evaluation, scintigraphy, MRI, and ultrasound were each more sensitive than conventional radiography in detecting inflammatory soft tissue lesions as well as destructive joint processes in arthritis patients in group 1. All differences were statistically significant. We found ultrasound to be even more sensitive than MRI in the detection of synovitis. MRI detected erosions in 92 finger joints (20%; 26 patients) in group 1 that had not been detected by conventional radiography.
Conclusion
Our data indicate that MRI and ultrasound are valuable diagnostic methods in patients with arthritis who have normal findings on radiologic evaluation.
639 citations
TL;DR: Roflumilast improves lung function in patients with COPD treated with salmeterol or tiotropium, and could become an important treatment for these patients.
571 citations
TL;DR: A theoretical model is developed for some acoustic properties, particularly the scatter and absorption, of this contrast agent, considering the individual microspheres as air bubbles surrounded by a thin shell, and it is concluded that the model correlates well with these acoustic measurements.
512 citations
TL;DR: The state-of-the-art in development of log P prediction approaches falling in two major categories: substructure-based and property-based methods are reviewed and a simple equation based on the number of carbon atoms, NC, and thenumber of hetero atoms, NHET is proposed.
507 citations
Authors
Showing all 1811 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Carsten Denkert | 93 | 504 | 34719 |
| Richard H. Holm | 87 | 580 | 29249 |
| Christer Johansson | 64 | 378 | 15936 |
| Manfred Dietel | 57 | 180 | 12045 |
| Rob J. van der Geest | 55 | 292 | 9515 |
| Peter Fischer | 53 | 285 | 9632 |
| Christian Weimar | 49 | 244 | 13687 |
| Steven C. Quay | 47 | 325 | 8202 |
| Lars Aabakken | 45 | 220 | 9117 |
| Anders Karlsson | 45 | 239 | 6551 |
| António M. Baptista | 45 | 191 | 7171 |
| Håkan Wikström | 43 | 137 | 6257 |
| Jan Henrik Ardenkjær-Larsen | 42 | 258 | 11440 |
| Ross W. Stephens | 41 | 133 | 5768 |
| Aurelia Noske | 40 | 97 | 7196 |