Institution
Royal Children's Hospital
Healthcare•Melbourne, Victoria, Australia•
About: Royal Children's Hospital is a healthcare organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 9267 authors who have published 18915 publications receiving 802386 citations. The organization is also known as: Royal Children's Hospital Melbourne & RCH.
Topics: Population, Poison control, Medicine, Mental health, Health care
Papers published on a yearly basis
Papers
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TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
Abstract: limma is an R/Bioconductor software package that provides an integrated solution for analysing data from gene expression experiments. It contains rich features for handling complex experimental designs and for information borrowing to overcome the problem of small sample sizes. Over the past decade, limma has been a popular choice for gene discovery through differential expression analyses of microarray and high-throughput PCR data. The package contains particularly strong facilities for reading, normalizing and exploring such data. Recently, the capabilities of limma have been significantly expanded in two important directions. First, the package can now perform both differential expression and differential splicing analyses of RNA sequencing (RNA-seq) data. All the downstream analysis tools previously restricted to microarray data are now available for RNA-seq as well. These capabilities allow users to analyse both RNA-seq and microarray data with very similar pipelines. Second, the package is now able to go past the traditional gene-wise expression analyses in a variety of ways, analysing expression profiles in terms of co-regulated sets of genes or in terms of higher-order expression signatures. This provides enhanced possibilities for biological interpretation of gene expression differences. This article reviews the philosophy and design of the limma package, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
22,147 citations
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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
11,809 citations
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Theo Vos1, Amanuel Alemu Abajobir, Kalkidan Hassen Abate2, Cristiana Abbafati3 +775 more•Institutions (305)
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016.
10,401 citations
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TL;DR: In this paper, the authors estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010.
9,324 citations
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TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
7,021 citations
Authors
Showing all 9301 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hugh A. Sampson | 147 | 816 | 76492 |
Terho Lehtimäki | 142 | 1304 | 106981 |
Graham G. Giles | 136 | 1249 | 80038 |
Savio L. C. Woo | 135 | 785 | 62270 |
Samuel F. Berkovic | 132 | 757 | 63648 |
Christopher G. Maher | 128 | 940 | 73131 |
David Robertson | 127 | 1106 | 67914 |
Louisa Degenhardt | 126 | 798 | 139683 |
Myron M. Levine | 123 | 789 | 60865 |
Peter J. Anderson | 120 | 966 | 63635 |
Salvatore DiMauro | 119 | 647 | 51435 |
Rupert Timpl | 118 | 410 | 40457 |
George C Patton | 118 | 578 | 94634 |
Ingrid E. Scheffer | 113 | 585 | 53463 |
Hugh R. Taylor | 112 | 775 | 93584 |