Institution
Royal Edinburgh Hospital
Healthcare•Edinburgh, United Kingdom•
About: Royal Edinburgh Hospital is a healthcare organization based out in Edinburgh, United Kingdom. It is known for research contribution in the topics: Population & Schizophrenia. The organization has 1187 authors who have published 1662 publications receiving 81644 citations.
Papers published on a yearly basis
Papers
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1,444 citations
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Royal Edinburgh Hospital1, King's College London2, Centre for Mental Health3, University of Glasgow4, University of Edinburgh5, Medical Research Council6, University of Münster7, University of Melbourne8, University of Freiburg9, University of Queensland10, Charité11, Broad Institute12, Harvard University13, Karolinska Institutet14, University of North Carolina at Chapel Hill15
TL;DR: A genetic meta-analysis of depression found 269 associated genes that highlight several potential drug repositioning opportunities, and relationships with depression were found for neuroticism and smoking.
Abstract: Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that has remained difficult to elucidate with current sample sizes due to the polygenic nature of the disorder. To maximize sample size, we meta-analyzed data on 807,553 individuals (246,363 cases and 561,190 controls) from the three largest genome-wide association studies of depression. We identified 102 independent variants, 269 genes, and 15 genesets associated with depression, including both genes and gene pathways associated with synaptic structure and neurotransmission. An enrichment analysis provided further evidence of the importance of prefrontal brain regions. In an independent replication sample of 1,306,354 individuals (414,055 cases and 892,299 controls), 87 of the 102 associated variants were significant after multiple testing correction. These findings advance our understanding of the complex genetic architecture of depression and provide several future avenues for understanding etiology and developing new treatment approaches.
1,312 citations
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TL;DR: The notion that some patients with schizophrenia have difficulties with tasks requiring 'theory of mind' skills and that this deficiency is symptom specific is supported.
1,198 citations
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Cardiff University1, University of Birmingham2, Broad Institute3, University of Pittsburgh4, University of Pennsylvania5, Harvard University6, King's College London7, University of Aberdeen8, Trinity College, Dublin9, Royal Edinburgh Hospital10, University College London11, Royal Victoria Infirmary12
TL;DR: The results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder and found further support for the previously reported CACNA1C.
Abstract: To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
1,182 citations
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TL;DR: A substantial overlap exists between the individual syndromes and that the similarities between them outweigh the differences, and it is concluded that a dimensional classification is likely to be more productive.
1,149 citations
Authors
Showing all 1188 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ian J. Deary | 166 | 1795 | 114161 |
Steven Williams | 144 | 1375 | 86712 |
Keith A.A. Fox | 136 | 830 | 95960 |
Keith Hawton | 125 | 657 | 55138 |
Vince D. Calhoun | 117 | 1234 | 62205 |
John M. Starr | 116 | 695 | 48761 |
Christopher G. Fairburn | 113 | 343 | 51987 |
Guy M. Goodwin | 109 | 580 | 43407 |
Gordon D Murray | 107 | 393 | 47440 |
Andrew M. McIntosh | 98 | 693 | 50664 |
Jonathan R. T. Davidson | 93 | 420 | 31301 |
Stephen M. Lawrie | 90 | 488 | 32376 |
Michael Sharpe | 84 | 417 | 30546 |
John R. Geddes | 83 | 441 | 37064 |
Ian H. Robertson | 81 | 362 | 23146 |