Institution
Sunnybrook Health Sciences Centre
Healthcare•Toronto, Ontario, Canada•
About: Sunnybrook Health Sciences Centre is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Medicine. The organization has 7689 authors who have published 15236 publications receiving 523019 citations. The organization is also known as: Sunnybrook.
Topics: Population, Medicine, Health care, Breast cancer, Cancer
Papers published on a yearly basis
Papers
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TL;DR: The Balance Scale was the most efficient measure to statistically discriminate between subjects according to their use of each type of mobility aide (walker, cane, no aids) and supports the validity of the Balance Scale in this geriatric population.
1,204 citations
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TL;DR: Overexpression of p59ILK disrupted epithelial cell architecture and inhibited adhesion to integrin substrates, while inducing anchorage-independent growth, and is proposed that ILK is a receptor-proximal protein kinase regulating integrin-mediated signal transduction.
Abstract: THE interaction of cells with the extracellular matrix regulates cell shape, motility, growth, survival, differentiation and gene expression, through integrin-mediated signal transduction1–3. We used a two-hybrid screen to isolate genes encoding proteins that interact with the β1-integrin cytoplasmic domain. The most frequently isolated complementary DNA encoded a new, 59K serine/threonine protein kinase, containing four ankyrin-like repeats. We report here that this integrin-linked kinase (ILK) phosphorylated a β1-integrin cytoplasmic domain peptide in vitro and coimmunoprecipitated with β1 in lysates of mammalian cells. Endogenous ILK kinase activity was reduced in response to fibronectin. Overexpression of p59ILK disrupted epithelial cell architecture and inhibited adhesion to integrin substrates, while inducing anchorage-independent growth. We propose that ILK is a receptor-proximal protein kinase regulating integrin-mediated signal transduction.
1,162 citations
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TL;DR: Bivalirudin with provisional Gp IIb/IIIa blockade is statistically not inferior to heparin plus planned Gp IIIa blockade during contemporary PCI with regard to suppression of acute ischemic end points and is associated with less bleeding.
Abstract: ContextThe direct thrombin inhibitor bivalirudin has been associated with better
efficacy and less bleeding than heparin during coronary balloon angioplasty
but has not been widely tested during contemporary percutaneous coronary intervention
(PCI).ObjectiveTo determine the efficacy of bivalirudin, with glycoprotein IIb/IIIa
(Gp IIb/IIIa) inhibition on a provisional basis for complications during PCI,
compared with heparin plus planned Gp IIb/IIIa blockade with regard to protection
from periprocedural ischemic and hemorrhagic complications.Design, Setting, and ParticipantsThe Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical
Events (REPLACE)–2 trial, a randomized, double-blind, active-controlled
trial conducted among 6010 patients undergoing urgent or elective PCI at 233
community or referral hospitals in 9 countries from October 2001 through August
2002.InterventionsPatients were randomly assigned to receive intravenous bivalirudin (0.75-mg/kg
bolus plus 1.75 mg/kg per hour for the duration of PCI), with provisional
Gp IIb/IIIa inhibition (n = 2999), or heparin (65-U/kg bolus) with planned
Gp IIb/IIIa inhibition (abciximab or eptifibatide) (n = 3011). Both groups
received daily aspirin and a thienopyridine for at least 30 days after PCI.Main Outcome MeasuresThe primary composite end point was 30-day incidence of death, myocardial
infarction, urgent repeat revascularization, or in-hospital major bleeding;
the secondary composite end point was 30-day incidence of death, myocardial
infarction, or urgent repeat revascularization.ResultsProvisional Gp IIb/IIIa blockade was administered to 7.2% of patients
in the bivalirudin group. By 30 days, the primary composite end point had
occurred among 9.2% of patients in the bivalirudin group vs 10.0% of patients
in the heparin-plus-Gp IIb/IIIa group (odds ratio, 0.92; 95% confidence interval,
0.77-1.09; P = .32). The secondary composite end
point occurred in 7.6% of patients in the bivalirudin vs 7.1% of patients
in the heparin-plus-Gp IIb/IIIa groups (odds ratio, 1.09; 95% confidence interval
0.90-1.32; P = .40). Prespecified statistical criteria
for noninferiority to heparin plus Gp IIb/IIIa were satisfied for both end
points. In-hospital major bleeding rates were significantly reduced by bivalirudin
(2.4% vs 4.1%; P<.001).ConclusionsBivalirudin with provisional Gp IIb/IIIa blockade is statistically not
inferior to heparin plus planned Gp IIb/IIIa blockade during contemporary
PCI with regard to suppression of acute ischemic end points and is associated
with less bleeding.
1,148 citations
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TL;DR: The Gastrointestinal Quality of Life Index (GIQLI) is ready to be used in clinical practice and research and validated against other generic measures of quality of life.
Abstract: At present, an instrument for measuring the quality of life, specifically for patients with gastrointestinal disease, is not available. A new instrument for gastrointestinal disorders that is system-specific has been developed in three phases. In the first phase, questions were collated and then tested on 70 patients with gastrointestinal diseases and those that worked well were retained. In the second phase, the questions were modified and tested on 204 patients and the results verified by international experts. The instrument was also validated against other generic measures of quality of life. During the third phase, the instrument was validated with 168 normal individuals. Reproducibility was tested on 25 patients with stable gastrointestinal disease and responsiveness was tested on 194 patients undergoing laparoscopic cholecystectomy. The result is a bilingual (German and English) questionnaire containing 36 questions each with five response categories. The responses to questions are summed to give a numerical score. It is concluded that the Gastrointestinal Quality of Life Index (GIQLI) is ready to be used in clinical practice and research.
1,141 citations
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TL;DR: Increases in the level of breast tissue density as assessed by mammography are associated with increases in risk for breast cancer, and these results show that increases in theLevel of breast cancer risk associated with increasing mammographic density is shown.
Abstract: BACKGROUND The radiographic appearance of the female breast varies from woman to woman depending on the relative amounts of fat and connective and epithelial tissues present. Variations in the mammographic density of breast tissue are referred to as the parenchymal pattern of the breast. Fat is radiologically translucent or clear (darker appearance), and both connective and epithelial tissues are radiologically dense (lighter appearance). Previous studies have generally supported an association between parenchymal patterns and breast cancer risk (greater risk with increasing densities), but there has been considerable heterogeneity in risk estimates reported. PURPOSE Our objective was to determine the level of breast cancer risk associated with varying mammographic densities by quantitatively classifying breast density with conventional radiological methods and novel computer-assisted methods. METHODS From the medical records of a cohort of 45,000 women assigned to mammography in the Canadian National Breast Cancer Screening Study (NBSS), a multicenter, randomized trial, mammograms from 354 case subjects and 354 control subjects were identified. Case subjects were selected from those women in whom histologically verified invasive breast cancer had developed 12 months or more after entering the trial. Control subjects were selected from those of similar age who, after a similar period of observation, had not developed breast cancer. The mammogram taken at the beginning of the NBSS was the image used for measurements. Mammograms were classified into six categories of density, either by radiologists or by computer-assisted measurements. All radiological classification and computer-assisted measurements were made using one craniocaudal view from the breast contralateral to the cancer site in case subjects and the corresponding breast of control subjects. All P values represent two-sided tests of statistical significance. RESULTS For all subjects, there was a 43% increase in the relative risk (RR) between the lower and the next higher category of density, as determined by radiologists, and there was a 32% increase as determined by the computer-assisted method. For all subjects, the RR in the most extensive category relative to the least was 6.05 (95% confidence interval [CI] = 2.82-12.97) for radiologists and 4.04 (95% CI = 2.12-7.69) for computer-assisted methods. Statistically significant increases in breast cancer risk associated with increasing mammographic density were found by both radiologists and computer-assisted methods for women in the age category 40-49 years (P = .005 for radiologists and P = .003 for computer-assisted measurements) and the age category 50-59 years (P = .002 for radiologists and P = .001 for computer-assisted measurements). CONCLUSION These results show that increases in the level of breast tissue density as assessed by mammography are associated with increases in risk for breast cancer.
1,128 citations
Authors
Showing all 7765 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gordon B. Mills | 187 | 1273 | 186451 |
David A. Bennett | 167 | 1142 | 109844 |
Bruce R. Rosen | 148 | 684 | 97507 |
Robert Tibshirani | 147 | 593 | 326580 |
Steven A. Narod | 134 | 970 | 84638 |
Peter Palese | 132 | 526 | 57882 |
Gideon Koren | 129 | 1994 | 81718 |
John B. Holcomb | 120 | 733 | 53760 |
Julie A. Schneider | 118 | 492 | 56843 |
Patrick Maisonneuve | 118 | 582 | 53363 |
Mitch Dowsett | 114 | 478 | 62453 |
Ian D. Graham | 113 | 700 | 87848 |
Peter C. Austin | 112 | 657 | 60156 |
Sandra E. Black | 104 | 681 | 51755 |
Michael B. Yaffe | 102 | 379 | 41663 |