University College London

About: University College London is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 81105 authors who have published 210603 publications receiving 9868552 citations. The organization is also known as: UCL & University College, London.

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Abstract: Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is known about their etiology and pathogenesis. We previously mapped a gene that predisposes to multiple fibroids, cutaneous leiomyomata and renal cell carcinoma to chromosome 1q42.3-q43 (refs 4-6). Here we show, through a combination of mapping critical recombinants, identifying individuals with germline mutations and screening known and predicted transcripts, that this gene encodes fumarate hydratase, an enzyme of the tricarboxylic acid cycle. Leiomyomatosis-associated mutations are predicted to result in absent or truncated protein, or substitutions or deletions of highly conserved amino acids. Activity of fumarate hydratase is reduced in lymphoblastoid cells from individuals with leiomyomatosis. This enzyme acts as a tumor suppressor in familial leiomyomata, and its measured activity is very low or absent in tumors from individuals with leiomyomatosis. Mutations in FH also occur in the recessive condition fumarate hydratase deficiency, and some parents of people with this condition are susceptible to leiomyomata. Thus, heterozygous and homozygous or compound heterozygous mutants have very different clinical phenotypes. Our results provide clues to the pathogenesis of fibroids and emphasize the importance of mutations of housekeeping and mitochondrial proteins in the pathogenesis of common types of tumor.

Load Theory of Selective Attention and Cognitive Control

Abstract: A load theory of attention in which distractor rejection depends on the level and type of load involved in current processing was tested. A series of experiments demonstrates that whereas high perceptual load reduces distractor interference, working memory load or dual-task coordination load increases distractor interference. These findings suggest 2 selective attention mechanisms: a perceptual selection mechanism serving to reduce distractor perception in situations of high perceptual load that exhaust perceptual capacity in processing relevant stimuli and a cognitive control mechanism that reduces interference from perceived distractors as long as cognitive control functions are available to maintain current priorities (low cognitive load). This theory resolves the long-standing early versus late selection debate and clarifies the role of cognitive control in selective attention.

The Moderate Resolution Imaging Spectroradiometer (MODIS): land remote sensing for global change research

Abstract: The first Moderate Resolution Imaging Spectroradiometer (MODIS) instrument is planned for launch by NASA in 1998. This instrument will provide a new and improved capability for terrestrial satellite remote sensing aimed at meeting the needs of global change research. The MODIS standard products will provide new and improved tools for moderate resolution land surface monitoring. These higher order data products have been designed to remove the burden of certain common types of data processing from the user community and meet the more general needs of global-to-regional monitoring, modeling, and assessment. The near-daily coverage of moderate resolution data from MODIS, coupled with the planned increase in high-resolution sampling from Landsat 7, will provide a powerful combination of observations. The full potential of MODIS will be realized once a stable and well-calibrated time-series of multispectral data has been established. In this paper the proposed MODIS standard products for land applications are described along with the current plans for data quality assessment and product validation.