University of California, Los Angeles

About: University of California, Los Angeles is a education organization based out in Los Angeles, California, United States. It is known for research contribution in the topics: Population & Health care. The organization has 125991 authors who have published 282429 publications receiving 15785853 citations. The organization is also known as: UCLA & UC Los Angeles.

Electrical Energy Storage for the Grid: A Battery of Choices

Abstract: The increasing interest in energy storage for the grid can be attributed to multiple factors, including the capital costs of managing peak demands, the investments needed for grid reliability, and the integration of renewable energy sources. Although existing energy storage is dominated by pumped hydroelectric, there is the recognition that battery systems can offer a number of high-value opportunities, provided that lower costs can be obtained. The battery systems reviewed here include sodium-sulfur batteries that are commercially available for grid applications, redox-flow batteries that offer low cost, and lithium-ion batteries whose development for commercial electronics and electric vehicles is being applied to grid storage.

First year Wilkinson Microwave Anisotropy Probe (WMAP) observations: Determination of cosmological parameters

Abstract: WMAP precision data enable accurate testing of cosmological models. We find that the emerging standard model of cosmology, a flat � -dominated universe seeded by a nearly scale-invariant adiabatic Gaussian fluctuations, fits the WMAP data. For the WMAP data only, the best-fit parameters are h ¼ 0:72 � 0:05, � bh 2 ¼ 0:024 � 0:001, � mh 2 ¼ 0:14 � 0:02, � ¼ 0:166 þ0:076 � 0:071 , ns ¼ 0:99 � 0:04, and � 8 ¼ 0:9 � 0:1. With parameters fixed only by WMAP data, we can fit finer scale cosmic microwave background (CMB) measure- ments and measurements of large-scale structure (galaxy surveys and the Lyforest). This simple model is also consistent with a host of other astronomical measurements: its inferred age of the universe is consistent with stellar ages, the baryon/photon ratio is consistent with measurements of the (D/H) ratio, and the inferred Hubble constant is consistent with local observations of the expansion rate. We then fit the model parameters to a combination of WMAP data with other finer scale CMB experiments (ACBAR and CBI), 2dFGRS measurements, and Lyforest data to find the model's best-fit cosmological parameters: h ¼ 0:71 þ0:04 � 0:03 , � bh 2 ¼ 0:0224 � 0:0009, � mh 2 ¼ 0:135 þ0:008 � 0:009 , � ¼ 0:17 � 0:06, ns(0.05 Mpc � 1 )=0 :93 � 0:03, and � 8 ¼ 0:84 � 0:04. WMAP's best determination of � ¼ 0:17 � 0:04 arises directly from the temperature- polarization (TE) data and not from this model fit, but they are consistent. These parameters imply that the age of the universe is 13:7 � 0:2 Gyr. With the Lyforest data, the model favors but does not require a slowly varying spectral index. The significance of this running index is sensitive to the uncertainties in the Ly� forest. By combining WMAP data with other astronomical data, we constrain the geometry of the universe, � tot ¼ 1:02 � 0:02, and the equation of state of the dark energy, w < � 0:78 (95% confidence limit assuming w �� 1). The combination of WMAP and 2dFGRS data constrains the energy density in stable neutrinos: � � h 2 < 0:0072 (95% confidence limit). For three degenerate neutrino species, this limit implies that their mass is less than 0.23 eV (95% confidence limit). The WMAP detection of early reionization rules out warm dark matter. Subject headings: cosmic microwave background — cosmological parameters — cosmology: observations — early universe On-line material: color figure

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

Abstract: Background The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25 to 30 percent of breast cancers, increasing the aggressiveness of the tumor. Methods We evaluated the efficacy and safety of trastuzumab, a recombinant monoclonal antibody against HER2, in women with metastatic breast cancer that overexpressed HER2. We randomly assigned 234 patients to receive standard chemotherapy alone and 235 patients to receive standard chemotherapy plus trastuzumab. Patients who had not previously received adjuvant (postoperative) therapy with an anthracycline were treated with doxorubicin (or epirubicin in the case of 36 women) and cyclophosphamide with (143 women) or without trastuzumab (138 women). Patients who had previously received adjuvant anthracycline were treated with paclitaxel alone (96 women) or paclitaxel with trastuzumab (92 women). Results The addition of trastuzumab to chemotherapy was associated with a longer time to disease progression (median, 7.4 ...

Active contours without edges

Abstract: We propose a new model for active contours to detect objects in a given image, based on techniques of curve evolution, Mumford-Shah (1989) functional for segmentation and level sets. Our model can detect objects whose boundaries are not necessarily defined by the gradient. We minimize an energy which can be seen as a particular case of the minimal partition problem. In the level set formulation, the problem becomes a "mean-curvature flow"-like evolving the active contour, which will stop on the desired boundary. However, the stopping term does not depend on the gradient of the image, as in the classical active contour models, but is instead related to a particular segmentation of the image. We give a numerical algorithm using finite differences. Finally, we present various experimental results and in particular some examples for which the classical snakes methods based on the gradient are not applicable. Also, the initial curve can be anywhere in the image, and interior contours are automatically detected.