Institution
University of Chicago
Education•Chicago, Illinois, United States•
About: University of Chicago is a education organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 66716 authors who have published 160098 publications receiving 9644339 citations. The organization is also known as: Chicago University & U of C.
Topics: Population, Cancer, Galaxy, Gene, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: An animal model of conditional Tet2 loss in the hematopoietic compartment that leads to increased stem cell self-renewal in vivo as assessed by competitive transplant assays is reported.
1,100 citations
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TL;DR: In this paper, the problem of combining price relatives of repeat sales of properties to obtain a price index can be converted into a regression problem, and standard techniques of regression analysis can be used to estimate the index.
Abstract: Quality differences make estimation of price indexes for real properties difficult, but these can be largely avoided by basing an index on sales prices of the same property at different times. The problem of combining price relatives of repeat sales of properties to obtain a price index can be converted into a regression problem, and standard techniques of regression analysis can be used to estimate the index. This method of estimation is more efficient than others for combining price relatives in that it utilizes information about the price index for earlier periods contained in sales prices in later periods. Standard errors of the estimated index numbers can be readily computed using the regression method, and it permits certain effects on the value of real properties to be eliminated from the index.
1,100 citations
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TL;DR: In this paper, a haplotype-based haplotype relative risk (HHRR) method was used to test for association between a VNTR polymorphism at the dopamine transporter locus (DAT1) and DSM-III-R-diagnosed ADHD and undifferentiated attention-deficit disorder (UADD) in trios composed of father, mother, and affected offspring.
Abstract: Attention-deficit hyperactivity disorder (ADHD) has been shown to be familial and heritable, in previous studies. As with most psychiatric disorders, examination of pedigrees has not revealed a consistent Mendelian mode of transmission. The response of ADHD patients to medications that inhibit the dopamine transporter, including methylphenidate, amphetamine, pemoline, and bupropion, led us to consider the dopamine transporter as a primary candidate gene for ADHD. To avoid effects of population stratification and to avoid the problem of classification of relatives with other psychiatric disorders as affected or unaffected, we used the haplotype-based haplotype relative risk (HHRR) method to test for association between a VNTR polymorphism at the dopamine transporter locus (DAT1) and DSM-III-R-diagnosed ADHD (N = 49) and undifferentiated attention-deficit disorder (UADD) (N = 8) in trios composed of father, mother, and affected offspring. HHRR analysis revealed significant association between ADHD/UADD and the 480-bp DAT1 allele (chi 2 7.51, 1 df, P = .006). When cases of UADD were dropped from the analysis, similar results were found (Chi 2 7.29, 1 df, P = .007). If these findings are replicated, molecular analysis of the dopamine transporter gene may identify mutations that increase susceptibility to ADHD/UADD. Biochemical analysis of such mutations may lead to development of more effective therapeutic interventions.
1,099 citations
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Kevork N. Abazajian1, Jennifer K. Adelman-McCarthy2, Marcel A. Agüeros3, Sahar S. Allam4 +162 more•Institutions (41)
TL;DR: The second data release of the Sloan Digital Sky Survey (SDSS) as mentioned in this paper is the most recent data set to be publicly available, which consists of 3.5 million unique objects, 367,360 spectra of galaxies, quasars, stars, and calibrating blank sky patches selected over 2627 deg2 of this area.
Abstract: The Sloan Digital Sky Survey (SDSS) has validated and made publicly available its Second Data Release. This data release consists of 3324 deg2 of five-band (ugriz) imaging data with photometry for over 88 million unique objects, 367,360 spectra of galaxies, quasars, stars, and calibrating blank sky patches selected over 2627 deg2 of this area, and tables of measured parameters from these data. The imaging data reach a depth of r ≈ 22.2 (95% completeness limit for point sources) and are photometrically and astrometrically calibrated to 2% rms and 100 mas rms per coordinate, respectively. The imaging data have all been processed through a new version of the SDSS imaging pipeline, in which the most important improvement since the last data release is fixing an error in the model fits to each object. The result is that model magnitudes are now a good proxy for point-spread function magnitudes for point sources, and Petrosian magnitudes for extended sources. The spectroscopy extends from 3800 to 9200 A at a resolution of 2000. The spectroscopic software now repairs a systematic error in the radial velocities of certain types of stars and has substantially improved spectrophotometry. All data included in the SDSS Early Data Release and First Data Release are reprocessed with the improved pipelines and included in the Second Data Release. Further characteristics of the data are described, as are the data products themselves and the tools for accessing them.
1,098 citations
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TL;DR: Density is related approximately reciprocally to individual metabolic requirements, indicating that the energy used by the local population of a species in the community is independent of its body size.
Abstract: There seems to be an inverse relationship between the size of an animal species and its local abundance. Here I describe the interspecific seating of population density and body mass among mammalian primary consumers (herbivores, broadly defined). Density is related approximately reciprocally to individual metabolic requirements, indicating that the energy used by the local population of a species in the community is independent of its body size. I suggest that this is a more general rule of community structure.
1,098 citations
Authors
Showing all 67909 results
Name | H-index | Papers | Citations |
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George M. Whitesides | 240 | 1739 | 269833 |
Solomon H. Snyder | 232 | 1222 | 200444 |
Eugene Braunwald | 230 | 1711 | 264576 |
Kari Stefansson | 206 | 794 | 174819 |
Hagop M. Kantarjian | 204 | 3708 | 210208 |
David Miller | 203 | 2573 | 204840 |
Martin White | 196 | 2038 | 232387 |
Craig B. Thompson | 195 | 557 | 173172 |
Robert C. Nichol | 187 | 851 | 162994 |
Jing Wang | 184 | 4046 | 202769 |
Patrick O. Brown | 183 | 755 | 200985 |
Yusuke Nakamura | 179 | 2076 | 160313 |
H. S. Chen | 179 | 2401 | 178529 |
Joseph Biederman | 179 | 1012 | 117440 |
Daniel J. Eisenstein | 179 | 672 | 151720 |