Institution
University of Málaga
Education•Málaga, Spain•
About: University of Málaga is a education organization based out in Málaga, Spain. It is known for research contribution in the topics: Population & Catalysis. The organization has 11427 authors who have published 26180 publications receiving 499357 citations. The organization is also known as: University of Malaga & Universidad de Málaga.
Papers published on a yearly basis
Papers
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TL;DR: The area under the receiver operating characteristic (ROC) curve, known as the AUC, is currently considered to be the standard method to assess the accuracy of predictive distribution models as discussed by the authors.
Abstract: The area under the receiver operating characteristic (ROC) curve, known as the AUC, is currently considered to be the standard method to assess the accuracy of predictive distribution models. It avoids the supposed subjectivity in the threshold selection process, when continuous probability derived scores are converted to a binary presence‐absence variable, by summarizing overall model performance over all possible thresholds. In this manuscript we review some of the features of this measure and bring into question its reliability as a comparative measure of accuracy between model results. We do not recommend using AUC for five reasons: (1) it ignores the predicted probability values and the goodness-of-fit of the model; (2) it summarises the test performance over regions of the ROC space in which one would rarely operate; (3) it weights omission and commission errors equally; (4) it does not give information about the spatial distribution of model errors; and, most importantly, (5) the total extent to which models are carried out highly influences the rate of well-predicted absences and the AUC scores.
2,711 citations
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TL;DR: This annotated reference sequence of wheat is a resource that can now drive disruptive innovation in wheat improvement, as this community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.
Abstract: An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.
2,118 citations
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TL;DR: The importance of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and catalase working together in human cells against toxic reactive oxygen species, their relationship with several pathophysiologic processes and their possible therapeutic implications are described.
2,000 citations
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TL;DR: In this paper, the authors measured place attachment within three spatial ranges (house, neighbourhood, and city) and two dimensions (physical and social), in order to establish some comparison between them.
1,888 citations
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Wellcome Trust Sanger Institute1, London Research Institute2, Katholieke Universiteit Leuven3, Max Planck Society4, GATC Biotech5, Université catholique de Louvain6, Centre national de la recherche scientifique7, University of Exeter8, Institut national agronomique Paris Grignon9, University of Málaga10, Pablo de Olavide University11, University of Salamanca12, University of Sussex13, Salk Institute for Biological Studies14, Stanford University15, Cold Spring Harbor Laboratory16, TigerLogic17, Rosalind Franklin University of Medicine and Science18, Russian Academy of Sciences19, Technical University of Denmark20
TL;DR: The genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote, is sequenced and highly conserved genes important for eukARYotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing are identified.
Abstract: We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. Some 43% of the genes contain introns, of which there are 4,730. Fifty genes have significant similarity with human disease genes; half of these are cancer related. We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. These genes may have originated with the appearance of eukaryotic life. Few similarly conserved genes that are important for multicellular organization were identified, suggesting that the transition from prokaryotes to eukaryotes required more new genes than did the transition from unicellular to multicellular organization.
1,686 citations
Authors
Showing all 11671 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kjell Fuxe | 142 | 1479 | 89846 |
Antonio Facchetti | 111 | 602 | 51885 |
Peter Salovey | 108 | 297 | 56135 |
Carl J. Lavie | 106 | 1135 | 49318 |
Pedro Romero | 93 | 358 | 32624 |
Guido Busca | 91 | 538 | 32109 |
Carlos M. Ferrario | 91 | 528 | 30339 |
Antonio J. Conejo | 89 | 339 | 27947 |
Luis M. Garcia-Segura | 88 | 484 | 27077 |
José Manuel García-Verdugo | 84 | 281 | 41309 |
Francisco Rodríguez | 79 | 748 | 24992 |
Jordi Vila | 75 | 539 | 21594 |
A. J. Castro-Tirado | 72 | 728 | 24272 |
Shigehiro Yamaguchi | 68 | 314 | 15406 |
Pedro Rodriguez | 67 | 496 | 24551 |