Institution
University of Porto
Education•Porto, Portugal•
About: University of Porto is a education organization based out in Porto, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 20807 authors who have published 64514 publications receiving 1557882 citations. The organization is also known as: U.Porto & Universidade do Porto.
Topics: Population, Context (language use), Medicine, Cancer, Stars
Papers published on a yearly basis
Papers
More filters
••
Spanish National Research Council1, University of Cambridge2, Complutense University of Madrid3, Max Planck Society4, Leibniz Institute for Astrophysics Potsdam5, University of La Laguna6, University of Zaragoza7, University of Vienna8, Masaryk University9, University of Sydney10, Centre national de la recherche scientifique11, Ruhr University Bochum12, Autonomous University of Madrid13, Australian Astronomical Observatory14, Paris Diderot University15, University of Copenhagen16, University of Missouri–Kansas City17, Tianjin Normal University18, Institut d'Astrophysique de Paris19, Charles University in Prague20, Academy of Sciences of the Czech Republic21, Macquarie University22, Instituto Superior Técnico23, University of Porto24, Heidelberg University25, University of Granada26, Kapteyn Astronomical Institute27, University of Edinburgh28
TL;DR: The Calar Alto Legacy Integral Field Area (CALIFA) survey as discussed by the authors was designed to provide a first step in this direction by obtaining spatially resolved spectroscopic information of a diameter selected sample of similar to 600 galaxies in the Local Universe.
Abstract: The final product of galaxy evolution through cosmic time is the population of galaxies in the local universe. These galaxies are also those that can be studied in most detail, thus providing a stringent benchmark for our understanding of galaxy evolution. Through the huge success of spectroscopic single-fiber, statistical surveys of the Local Universe in the last decade, it has become clear, however, that an authoritative observational description of galaxies will involve measuring their spatially resolved properties over their full optical extent for a statistically significant sample. We present here the Calar Alto Legacy Integral Field Area (CALIFA) survey, which has been designed to provide a first step in this direction. We summarize the survey goals and design, including sample selection and observational strategy. We also showcase the data taken during the first observing runs (June/July 2010) and outline the reduction pipeline, quality control schemes and general characteristics of the reduced data. This survey is obtaining spatially resolved spectroscopic information of a diameter selected sample of similar to 600 galaxies in the Local Universe (0.005 < z < 0.03). CALIFA has been designed to allow the building of two-dimensional maps of the following quantities: (a) stellar populations: ages and metallicities; (b) ionized gas: distribution, excitation mechanism and chemical abundances; and (c) kinematic properties: both from stellar and ionized gas components. CALIFA uses the PPAK integral field unit (IFU), with a hexagonal field-of-view of similar to 1.3 square', with a 100% covering factor by adopting a three-pointing dithering scheme. The optical wavelength range is covered from 3700 to 7000 angstrom, using two overlapping setups (V500 and V1200), with different resolutions: R similar to 850 and R similar to 1650, respectively. CALIFA is a legacy survey, intended for the community. The reduced data will be released, once the quality has been guaranteed. The analyzed data fulfill the expectations of the original observing proposal, on the basis of a set of quality checks and exploratory analysis: (i) the final datacubes reach a 3 sigma limiting surface brightness depth of similar to 23.0 mag/arcsec(2) for the V500 grating data (similar to 22.8 mag/arcsec(2) for V1200); (ii) about similar to 70% of the covered field-of-view is above this 3 sigma limit; (iii) the data have a blue-to-red relative flux calibration within a few percent in most of the wavelength range; (iv) the absolute flux calibration is accurate within similar to 8% with respect to SDSS; (v) the measured spectral resolution is similar to 85 km s(-1) for V1200 (similar to 150 km s(-1) for V500); (vi) the estimated accuracy of the wavelength calibration is similar to 5 km s(-1) for the V1200 data (similar to 10 km s(-1) for the V500 data); (vii) the aperture matched CALIFA and SDSS spectra are qualitatively and quantitatively similar. Finally, we show that we are able to carry out all measurements indicated above, recovering the properties of the stellar populations, the ionized gas and the kinematics of both components. The associated maps illustrate the spatial variation of these parameters across the field, reemphasizing the redshift dependence of single aperture spectroscopic measurements. We conclude from this first look at the data that CALIFA will be an important resource for archaeological studies of galaxies in the Local Universe.
1,143 citations
••
Cornell University1, University of Porto2, Imperial College London3, National Institutes of Health4, Memorial Sloan Kettering Cancer Center5, Princeton University6, Lawrence Berkeley National Laboratory7, Garvan Institute of Medical Research8, Stanford University9, University of Copenhagen10, Fred Hutchinson Cancer Research Center11
TL;DR: This Review summarizes the main processes and new mechanisms involved in the formation of the pre-metastatic niche and describes the main mechanisms used to modify organs of future metastasis.
Abstract: It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.
1,134 citations
••
Fermilab1, University of California, Santa Cruz2, Rensselaer Polytechnic Institute3, Princeton University4, University College London5, University of Texas at Austin6, Ohio State University7, Apache Corporation8, New Mexico State University9, University of Washington10, Max Planck Society11, Joint Institute for Nuclear Astrophysics12, University of Cambridge13, University of Porto14, University of Chicago15, University of Warwick16, Heidelberg University17, Case Western Reserve University18, American Museum of Natural History19, California Institute of Technology20, Australian National University21, Lawrence Berkeley National Laboratory22, University of Ljubljana23, Drexel University24, Pennsylvania State University25, Valparaiso University26, Austin Peay State University27, Adler Planetarium28, Johns Hopkins University29, Carnegie Institution for Science30, National Centre for Radio Astrophysics31, Texas Tech University32
TL;DR: The Sloan Extension for Galactic Understanding and Exploration (SEGUE) Survey as mentioned in this paper obtained approximately 240,000 moderate-resolution spectra from 3900 to 9000 of fainter Milky Way stars (14.0 10 per resolution element).
Abstract: The Sloan Extension for Galactic Understanding and Exploration (SEGUE) Survey obtained {approx}240,000 moderate-resolution (R {approx} 1800) spectra from 3900 {angstrom} to 9000 {angstrom} of fainter Milky Way stars (14.0 10 per resolution element, stellar atmospheric parameters are estimated, including metallicity, surface gravity, and effective temperature. SEGUE obtained 3500 deg{sup 2} of additional ugriz imaging (primarily at low Galactic latitudes) providing precise multicolor photometry ({sigma}(g, r, i) {approx} 2%), ({sigma}(u, z) {approx} 3%) and astrometry ({approx}0.1) for spectroscopic target selection. The stellar spectra, imaging data, and derived parameter catalogs for this survey are publicly available as part of Sloan Digital Sky Survey Data Release 7.
1,133 citations
••
Daniel J. Klionsky1, Amal Kamal Abdel-Aziz2, Sara Abdelfatah3, Mahmoud Abdellatif4 +2980 more•Institutions (777)
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
1,129 citations
••
TL;DR: This work presents LOSITAN, a selection detection workbench based on a well evaluated Fst-outlier detection method that greatly facilitates correct approximation of model parameters, provides data import and export functions, iterative contour smoothing and generation of graphics in a easy to use graphical user interface.
Abstract: Testing for selection is becoming one of the most important steps in the analysis of multilocus population genetics data sets. Existing applications are difficult to use, leaving many non-trivial, error-prone tasks to the user. Here we present LOSITAN, a selection detection workbench based on a well evaluated F
st
-outlier detection method. LOSITAN greatly facilitates correct approximation of model parameters (e.g., genome-wide average, neutral F
st
), provides data import and export functions, iterative contour smoothing and generation of graphics in a easy to use graphical user interface. LOSITAN is able to use modern multi-core processor architectures by locally parallelizing fdist, reducing computation time by half in current dual core machines and with almost linear performance gains in machines with more cores. LOSITAN makes selection detection feasible to a much wider range of users, even for large population genomic datasets, by both providing an easy to use interface and essential functionality to complete the whole selection detection process.
1,121 citations
Authors
Showing all 21379 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stephen J. O'Brien | 153 | 1062 | 93025 |
Marco Costa | 146 | 1458 | 105096 |
António Amorim | 136 | 1477 | 96519 |
Nuno Filipe Castro | 128 | 960 | 76945 |
João Carvalho | 126 | 1278 | 77017 |
Carlos Caldas | 122 | 547 | 73840 |
Jorge S. Reis-Filho | 121 | 590 | 56695 |
Graca Rocha | 118 | 312 | 84236 |
George C Patton | 118 | 578 | 94634 |
Rui L. Reis | 115 | 1608 | 63223 |
Nuno C. Santos | 114 | 885 | 47038 |
Carlo La Vecchia | 112 | 1265 | 56282 |
Henrik Clausen | 109 | 520 | 49820 |
Francisco A. Tomás-Barberán | 106 | 389 | 36505 |
Banglin Chen | 105 | 393 | 55287 |