Institution
University of Rostock
Education•Rostock, Germany•
About: University of Rostock is a education organization based out in Rostock, Germany. It is known for research contribution in the topics: Catalysis & Population. The organization has 14216 authors who have published 32296 publications receiving 755196 citations. The organization is also known as: Rostock University.
Topics: Catalysis, Population, Palladium, Ionic liquid, Aryl
Papers published on a yearly basis
Papers
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TL;DR: The results suggest that, in addition to mitigating primary particulate emissions, reducing the emissions of secondary aerosol precursors from fossil fuel combustion and biomass burning is likely to be important for controlling China’s PM2.5 levels and for reducing the environmental, economic and health impacts resulting from particulate pollution.
Abstract: Rapid industrialization and urbanization in developing countries has led to an increase in air pollution, along a similar trajectory to that previously experienced by the developed nations. In China, particulate pollution is a serious environmental problem that is influencing air quality, regional and global climates, and human health. In response to the extremely severe and persistent haze pollution experienced by about 800 million people during the first quarter of 2013 (refs 4, 5), the Chinese State Council announced its aim to reduce concentrations of PM2.5 (particulate matter with an aerodynamic diameter less than 2.5 micrometres) by up to 25 per cent relative to 2012 levels by 2017 (ref. 6). Such efforts however require elucidation of the factors governing the abundance and composition of PM2.5, which remain poorly constrained in China. Here we combine a comprehensive set of novel and state-of-the-art offline analytical approaches and statistical techniques to investigate the chemical nature and sources of particulate matter at urban locations in Beijing, Shanghai, Guangzhou and Xi'an during January 2013. We find that the severe haze pollution event was driven to a large extent by secondary aerosol formation, which contributed 30-77 per cent and 44-71 per cent (average for all four cities) of PM2.5 and of organic aerosol, respectively. On average, the contribution of secondary organic aerosol (SOA) and secondary inorganic aerosol (SIA) are found to be of similar importance (SOA/SIA ratios range from 0.6 to 1.4). Our results suggest that, in addition to mitigating primary particulate emissions, reducing the emissions of secondary aerosol precursors from, for example, fossil fuel combustion and biomass burning is likely to be important for controlling China's PM2.5 levels and for reducing the environmental, economic and health impacts resulting from particulate pollution.
3,372 citations
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TL;DR: Research suggests that ageing processes are modifiable and that people are living longer without severe disability, and this finding will be important for the chances to meet the challenges of ageing populations.
3,095 citations
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01 Jan 1987TL;DR: The Strong Perfect Graph Conjecture as discussed by the authors is based on the strong perfect graph conjecture, which is a generalization of the concept of generalized perfection, generalized perfection and related concepts.
Abstract: Preface 1. Basic Concepts 2. Perfection, Generalized Perfection, and Related Concepts 3. Cycles, Chords and Bridges 4. Models and Interactions 5. Vertex and Edge Orderings 6. Posets 7. Forbidden Subgraphs 8. Hypergraphs and Graphs 9. Matrices and Polyhedra 10. Distance Properties 11. Algebraic Compositions and Recursive Definitions 12. Decompositions and Cutsets 13. Threshold Graphs and Related Concepts 14. The Strong Perfect Graph Conjecture Appendix A. Recognition Appendix B. Containment Relationships Bibliography Index.
1,958 citations
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National Institutes of Health1, Norwegian University of Science and Technology2, National Research Council3, University of São Paulo4, University of Tübingen5, University of Coimbra6, University of Paris7, French Institute of Health and Medical Research8, Chang Gung University9, Columbia University10, Mayo Clinic11, Tel Aviv University12, Rambam Health Care Campus13, Technion – Israel Institute of Technology14, Tel Aviv Sourasky Medical Center15, University of Rostock16, University Health Network17, National Taiwan Normal University18, University of Washington19, University of Tokyo20, Kobe University21, Magna Græcia University22, University of Toronto23, Duke University24, Singapore General Hospital25
TL;DR: Data collected demonstrate that there is a strong association between GBA mutations and Parkinson's disease, and those with a GBA mutation presented earlier with the disease, were more likely to have affected relatives, and were morelikely to have atypical clinical manifestations.
Abstract: Background Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among patients with Parkinson's disease. We aimed to ascertain the frequency of GBA mutations in an ethnically diverse group of patients with Parkinson's disease. Methods Sixteen centers participated in our international, collaborative study: five from the Americas, six from Europe, two from Israel, and three from Asia. Each center genotyped a standard DNA panel to permit comparison of the genotyping results across centers. Genotypes and phenotypic data from a total of 5691 patients with Parkinson's disease (780 Ashkenazi Jews) and 4898 controls (387 Ashkenazi Jews) were analyzed, with multivariate logistic-regression models and the Mantel–Haenszel procedure used to estimate odds ratios across centers. Results All 16 centers could detect two GBA mutations, L444P and N370S. Among Ashkenazi Jewish subjects, either mutation was found in 15% of p...
1,629 citations
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University of Cologne1, Stanford University2, University of Ulsan3, Hanyang University4, Vancouver General Hospital5, University of Bonn6, University of North Carolina at Chapel Hill7, University of Rostock8, Epigenomics AG9, University of Tsukuba10, University Hospital Heidelberg11, Heidelberg University12, Schiller International University13, University of Zurich14, Vanderbilt University15, University of Belgrade16, Peter MacCallum Cancer Centre17, Casa Sollievo della Sofferenza18, University of Liverpool19, University of Zagreb20, Charité21, Oslo University Hospital22, VU University Medical Center23, Uppsala University24, Haukeland University Hospital25, Max Planck Society26, Memorial Sloan Kettering Cancer Center27, French Institute of Health and Medical Research28
TL;DR: This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.
Abstract: We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We discovered somatic genomic rearrangements of TP73 that create an oncogenic version of this gene, TP73Δex2/3. In rare cases, SCLC tumours exhibited kinase gene mutations, providing a possible therapeutic opportunity for individual patients. Finally, we observed inactivating mutations in NOTCH family genes in 25% of human SCLC. Accordingly, activation of Notch signalling in a pre-clinical SCLC mouse model strikingly reduced the number of tumours and extended the survival of the mutant mice. Furthermore, neuroendocrine gene expression was abrogated by Notch activity in SCLC cells. This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.
1,504 citations
Authors
Showing all 14396 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tim Adye | 143 | 1898 | 109010 |
Paul Jackson | 141 | 1372 | 93464 |
Carl-Henrik Heldin | 131 | 520 | 67528 |
Wolfgang Lohmann | 131 | 1488 | 88358 |
Marc Escalier | 129 | 1067 | 83546 |
Virginia Azzolini | 128 | 1153 | 79298 |
Stephen M. Stahl | 115 | 1477 | 61371 |
Gereon R. Fink | 114 | 867 | 60853 |
Matthias Beller | 113 | 733 | 46344 |
Harald Hampel | 109 | 601 | 65160 |
Sebastian Bachmann | 105 | 1119 | 50944 |
Roland Waldi | 99 | 1180 | 49943 |
Paul Knochel | 99 | 2373 | 44786 |
Javier Pérez-Ramírez | 97 | 540 | 34165 |
Matthias Beller | 97 | 903 | 34480 |