Showing papers by "University of Toronto published in 1994"

A Course in Game Theory

Abstract: A Course in Game Theory presents the main ideas of game theory at a level suitable for graduate students and advanced undergraduates, emphasizing the theory's foundations and interpretations of its basic concepts. The authors provide precise definitions and full proofs of results, sacrificing generalities and limiting the scope of the material in order to do so. The text is organized in four parts: strategic games, extensive games with perfect information, extensive games with imperfect information, and coalitional games. It includes over 100 exercises.

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Abstract: Most human acute myeloid leukaemia (AML) cells have limited proliferative capacity, suggesting that the leukaemic clone may be maintained by a rare population of stem cells. This putative leukaemic stem cell has not been characterized because the available in vitro assays can only detect progenitors with limited proliferative and replating potential. We have now identified an AML-initiating cell by transplantation into severe combined immune-deficient (SCID) mice. These cells homed to the bone marrow and proliferated extensively in response to in vivo cytokine treatment, resulting in a pattern of dissemination and leukaemic cell morphology similar to that seen in the original patients. Limiting dilution analysis showed that the frequency of these leukaemia-initiating cells in the peripheral blood of AML patients was one engraftment unit in 250,000 cells. We fractionated AML cells on the basis of cell-surface-marker expression and found that the leukaemia-initiating cells that could engraft SCID mice to produce large numbers of colony-forming progenitors were CD34+ CD38-; however, the CD34+ CD38+ and CD34- fractions contained no cells with these properties. This in vivo model replicates many aspects of human AML and defines a new leukaemia-initiating cell which is less mature than colony-forming cells.

A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery Disease

Abstract: Background Coronary-stent placement is a new technique in which a balloon-expandable, stainless-steel, slotted tube is implanted at the site of a coronary stenosis. The purpose of this study was to compare the effects of stent placement and standard balloon angioplasty on angiographically detected restenosis and clinical outcomes. Methods We randomly assigned 410 patients with symptomatic coronary disease to elective placement of a Palmaz-Schatz stent or to standard balloon angioplasty. Coronary angiography was performed at base line, immediately after the procedure, and six months later. Results The patients who underwent stenting had a higher rate of procedural success than those who underwent standard balloon angioplasty (96.1 percent vs. 89.6 percent, P = 0.011), a larger immediate increase in the diameter of the lumen (1.72 ±0.46 vs. 1.23 ±0.48 mm, P<0.001), and a larger luminal diameter immediately after the procedure (2.49 ±0.43 vs. 1.99 ±0.47 mm, P<0.001). At six months, the patients with stented ...

Toward a theory of interstellar turbulence. 2. Strong Alfvenic turbulence

Abstract: We continue to investigate the possibility that interstellar turbulence is caused by nonlinear interactions among shear Alfven waves. Here, as in Paper I, we restrict attention to the symmetric case where the oppositely directed waves carry equal energy fluxes. This precludes application to the solar wind in which the outward flux significantly exceeds the ingoing one. All our detailed calculations are carried out for an incompressible magnetized fluid. In incompressible magnetohydrodynamics (MHD), nonlinear interactions only occur between oppositely direct waves. Paper I contains a detailed derivation of the inertial range spectrum for the weak turbulence of shear Alfven waves. As energy cascades to high perpendicular wavenumbers, interactions become so strong that the assumption of weakness is no longer valid. Here, we present a theory for the strong turbulence of shear Alfven waves. It has the following main characteristics. (1) The inertial-range energy spectrum exhibits a critical balance beween linear wave periods and nonlinear turnover timescales. (2) The "eddies" are elongated in the direction of the field on small spatial scales; the parallel and perpendicular components of the wave vector, k_z and k_⊥, are related by k_z ≈ k^(2/3) _⊥L^(-1/3), where L is the outer scale of the turbulence. (3) The "one-dimensional" energy spectrum is proportional to k^(-5/3) _⊥-an anisotropic Kolmogorov energy spectrum. Shear Alfvenic turbulence mixes specific entropy as a passive contaminant. This gives rise to an electron density power spectrum whose form mimics the energy spectrum of the turbulence. Radio, wave scattering by these electron density fluctuations produces anisotropic scatter-broadened images. Damping by ion-neutral collisions restricts Alfvenic turbulence to highly ionized regions of the interstellar medium. We expect negligible generation of compressive MHD waves by shear Alfven waves belonging to the critically balanced cascade. Viscous and collisionless damping are also unimportant in the interstellar medium (ISM). Our calculations support the general picture of interstellar turbulence advanced by Higdon.

Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation

Abstract: The backbone dynamics of the C-terminal SH2 domain of phospholipase C gamma 1 have been investigated. Two forms of the domain were studied, one in complex with a high-affinity binding peptide derived from the platelet-derived growth factor receptor and the other in the absence of this peptide. 2-D 1H-15N NMR methods, employing pulsed field gradients, were used to determine steady-state 1H-15N NOE values and T1 and T2 15N relaxation times. Backbone dynamics were characterized by the overall correlation time (tau m), order parameters (S2), effective correlation times for internal motions (tau e), and, if required, terms to account for motions on a microsecond-to-millisecond-time scale. An extended two-time-scale formalism was used for residues having relaxation data and that could not be fit adequately using a single-time-scale formalism. The overall correlation times of the uncomplexed and complexed forms of SH2 were found to be 9.2 and 6.5 ns, respectively, suggesting that the uncomplexed form is in a monomer-dimer equilibrium. This was subsequently confirmed by hydrodynamic measurements. Analysis of order parameters reveals that residues in the so-called phosphotyrosine-binding loop exhibited higher than average disorder in both forms of SH2. Although localized differences in order parameters were observed between the uncomplexed and complexed forms of SH2, overall, higher order parameters were not found in the peptide-bound form, indicating that on average, picosecond-time-scale disorder is not reduced upon binding peptide. The relaxation data of the SH2-phosphopeptide complex were fit with fewer exchange terms than the uncomplexed form. This may reflect the monomer-dimer equilibrium that exists in the uncomplexed form or may indicate that the complexed form has lower conformational flexibility on a microsecond-to-millisecond-time scale.

Getting Personal: Reflexivity, Positionality, and Feminist Research∗

Abstract: Feminist and poststructural challenges to objectivist social science demand greater reflection by the researcher with the aim of producing more inclusive methods sensitive to the power relations in fieldwork. Following a discussion of contrasting approaches to these power relations, I present a reflexive examination of a research project on sexual identities. My reflections highlight some of the key ethical questions that face researchers conducting fieldwork, especially with regard to the relationship between the researcher and those being researched. My discussion of these dilemmas reflect the situated and partial nature of our understanding of “others.” I argue that the researcher's positionality and biography directly affect fieldwork and that fieldwork is a dialogical process which is structured by the researcher and the participants.

Sterile-neutrinos as dark matter

Abstract: The simplest model that can accommodate a viable nonbaryonic dark matter candidate is the standard electroweak theory with the addition of right-handed (sterile) neutrinos. We consider a single generation of neutrinos with a Dirac mass [mu] and a Majorana mass [ital M] for the right-handed component. If [ital M][much gt][mu] (standard hot dark matter corresponds to [ital M]=0), then sterile neutrinos are produced via oscillations in the early Universe with energy density independent of [ital M]. However, [ital M] is crucial in determining the large scale structure of the Universe; for [ital M][similar to]100 eV, sterile neutrinos make an excellent warm dark matter candidate.

A Prospective Study of Postural Balance and Risk of Falling in An Ambulatory and Independent Elderly Population

Abstract: BACKGROUND: An ability to predict risk of future falling is needed in order to target high-risk individuals for preventive intervention. The purpose of this study was to compare the ability of different measures of postural balance to predict risk of falling prospectively in an ambulatory and independent elderly population. METHODS: Balance tests were performed on 100 volunteers (aged 62-96), and falling was then monitored prospectively over a one-year period. The balance testing comprised measurements of: (a) spontaneous postural sway, (b) induced anterior-posterior sway, (c) induced medial-lateral sway, (d) anticipatory adjustments preceding volitional arm movements, (e) timed one-leg stance, and (f) performance on a clinical balance assessment scale. Small pseudorandom platform motions were used to perturb balance in the induced-sway tests. Using force plates, the spontaneous- and induced-sway responses were quantified in terms of the amplitude, speed, and mean frequency of the center-of-pressure displacement; input-output models were also used to parameterize the induced-sway performance. RESULTS: Although a number of measures showed evidence of significant differences between fallers and nonfallers, the differences were most pronounced for measures related to the control of lateral stability. Lateral spontaneous-sway amplitude (blindfolded conditions) was found to be the single best predictor of future falling risk, particularly for the large group of falls that were precipitated by a biomechanical perturbation. This measure was able to predict future falling risk with moderate accuracy, even in those individuals with no recent history of falling. CONCLUSIONS: The results suggest that control of lateral stability may be an important area for fall-preventative intervention. The ability of a simple and safe force-plate measure of spontaneous postural sway to predict future falling risk suggests a possible clinical application as a preliminary screening tool for risk of falling. Language: en

Tidal ventilation at low airway pressures can augment lung injury.

Abstract: Intermittent positive pressure ventilation with large tidal volumes and high peak airway pressures can result in pulmonary barotrauma. In the present study, we examined the hypothesis that ventilation at very low lung volumes can also worsen lung injury by repeated opening and closing of airway and alveolar duct units as ventilation occurs from below to above the infection point (Pinf) as determined from the inspiratory pressure-volume curve. We ventilated isolated, nonperfused, lavaged rat lungs with physiologic tidal volumes (5 to 6 ml/kg) at different end-expiratory pressures (above and below Pinf) and studied the effect on compliance and lung injury. In the groups ventilated with positive end-expiratory pressure (PEEP) below Pinf compliance fell dramatically after ventilation. It did not change in either the control group or the group ventilated with PEEP above Pinf. Lung injury assessed morphologically was significantly greater in the groups ventilated with a PEEP below Pinf, and in these groups the ...

Ice Age Paleotopography

Abstract: A gravitationally self-consistent theory of postglacial relative sea level change is used to infer the variation of surface ice and water cover since the Last Glacial Maximum (LGM). The results show that LGM ice volume was approximately 35 percent lower than suggested by the CLIMAP reconstruction and the maximum heights of the main Laurentian and Fennoscandian ice complexes are inferred to have been commensurately lower with respect to sea level. Use of these Ice Age boundary conditions in atmospheric general circulation models will yield climates that differ significantly from those previously inferred on the basis of the CLIMAP data set.

Robot pose estimation in unknown environments by matching 2D range scans

Abstract: We develop two algorithms to register a range scan to a previous scan so as to compute relative robot positions in an unknown environment The first algorithm is used on matching tangent lines defined on two scans and minimizing a distance function The second algorithm iteratively establishes correspondences between points in the two scans and then solves the point-to-point least-squares problem to compute the relative pose Our methods avoid the use of localized features They work in curved environments and can handle partial occlusions >

Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions.

Abstract: Neuromuscular preparations from third instar larvae of Drosophila are not well-maintained in commonly used physiological solutions: vacuoles form in the muscle fibers, and membrane potential declines. These problems may result from the Na:K ratio and total divalent cation content of these physiological solutions being quite different from those of haemolymph. Accordingly haemolymph-like solutions, based upon ion measurements of major cations, were developed and tested. Haemolymph-like solutions maintained the membrane potential at a relatively constant level, and prolonged the physiological life of the preparations. Synaptic transmission was well-maintained in haemolymph-like solutions, but the excitatory synaptic potentials had a slower time course and summated more effectively with repetitive stimulation, than in standard Drosophila solutions. Voltage-clamp experiments suggest that these effects are linked to more pronounced activation of muscle fiber membrane conductances in standard solutions, rather than to differences in passive muscle membrane properties or changes in postsynaptic receptor channel kinetics. Calcium dependence of transmitter release was steep in both standard and haemolymph-like solutions, but higher external calcium concentrations were required for a given level of release in haemolymph-like solutions. Thus, haemolymph-like solutions allow for prolonged, stable recording of synaptic transmission.

Trust in automation. I: Theoretical issues in the study of trust and human intervention in automated systems

Abstract: Today many systems are highly automated. The human operator's role in these systems is to supervise the automation and intervene to take manual control when necessary. The operator's choice of automatic or manual control has important consequences for system performance, and therefore it is important to understand and optimize this decision process. One important determinant of operators' choice of manual or automatic control may be their degree of trust in the automation. However, there have been no experimental tests of this hypothesis until recently, nor is there a model of human trust in machines to form a theoretical foundation for empirical studies. In this paper a model of human trust in machines is developed, taking models of trust between people as a starting point, and extending them to the human-machine relationship. The resulting model defines human trust in machines and specifies how trust changes with experience on a system, providing a framework for experimental research on trust a...

Social support and social structure: a descriptive epidemiology

Abstract: Despite a very large and growing literature demonstrating the significance of social support for health and well-being, surprisingly little is known about the social distribution of this crucial resource. This paper presents data on the distribution of social support and support resources across social class, marital status, age and gender, with the aims of contributing toward an understanding of the impact of social structures on processes of social support, and of assessing the hypothesis that epidemiological variations in mental health arise partially from social support differences. The epidemiology of perceived social support was found to correspond closely to the epidemiology of psychological distress and disorder. The single exception involved gender, where a positive rather than negative relationship was observed, with women demonstrating the highest levels of both social support and psychological distress. The observed patterns of variation in social support link this significant adaptive resource to one's locations in the social structure and reinforce the conclusion that it represents a promising intervention target. The practical importance of these results, however, are not matched by theoretical significance. Except in the case of marital status, our findings largely discount the hypothesis that the social distribution of mental health is partially attributable to social support differences.

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

Abstract: Experiments in amphibians have implicated fibroblast growth factors (FGFs) in the generation and patterning of mesoderm during embryogenesis. We have mutated the gene for fibroblast growth factor receptor 1 (fgfr-1) in the mouse to genetically dissect the role of FGF signaling during development. In the absence of fgfr-1 signaling, embryos displayed early growth defects; however, they remained capable of gastrulating and generating mesoderm. The nascent mesoderm of fgfr-1 homozygous mutant embryos differentiated into diverse mesodermal subtypes, but mesodermal patterning was aberrant. Somites were never generated and axial mesoderm was greatly expanded at the expense of paraxial mesoderm. These results suggest that FGFR-1 transduces signals that specify mesodermal cell fates and regional patterning of the mesoderm during gastrulation.

Artificial fishes: physics, locomotion, perception, behavior

Abstract: This paper proposes a framework for animation that can achieve the intricacy of motion evident in certain natural ecosystems with minimal input from the animator. The realistic appearance, movement, and behavior of individual animals, as well as the patterns of behavior evident in groups of animals fall within the scope of the framework. Our approach to emulating this level of natural complexity is to model each animal holistically as an autonomous agent situated in its physical world. To demonstrate the approach, we develop a physics-based, virtual marine world. The world is inhabited by artificial fishes that can swim hydrodynamically in simulated water through the motor control of internal muscles that motivates fins. Their repertoire of behaviors relies on their perception of the dynamic environment. As in nature, the detailed motions of artificial fishes in their virtual habitat are not entirely predictable because they are not scripted.

Flexible Discriminant Analysis by Optimal Scoring

Abstract: Fisher's linear discriminant analysis is a valuable tool for multigroup classification. With a large number of predictors, one can find a reduced number of discriminant coordinate functions that are “optimal” for separating the groups. With two such functions, one can produce a classification map that partitions the reduced space into regions that are identified with group membership, and the decision boundaries are linear. This article is about richer nonlinear classification schemes. Linear discriminant analysis is equivalent to multiresponse linear regression using optimal scorings to represent the groups. In this paper, we obtain nonparametric versions of discriminant analysis by replacing linear regression by any nonparametric regression method. In this way, any multiresponse regression technique (such as MARS or neural networks) can be postprocessed to improve its classification performance.

Toolglass and magic lenses: the see-through interface

Abstract: Toolglass widgets are new user interface tools that can appear, as though on a transparent sheet of glass, between an application and a traditional cursor. They can be positioned with one hand while the other positions the cursor. The widgets provide a rich and concise vocabulary for operating on application objects. These widgets may incorporate visual filters, called Magic Lens filters, that modify the presentation of application objects to reveal hidden information, to enhance data of interest, or to suppress distracting information. Together, these tools form a see-through interface that offers many advantages over traditional controls. They provide a new style of interaction that better exploits the user’s everyday skills. They can reduce steps, cursor motion, and errors. Many widgets can be provided in a user interface, by designers and by users, without requiring dedicated screen space. In addition, lenses provide rich context-dependent feedback and the ability to view details and context simultaneously. Our widgets and lenses can be combined to form operation and viewing macros, and can be used over multiple applications. CR

Regulation of NMDA receptors by tyrosine kinases and phosphatases.

Abstract: Protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) are key enzymes in signal-transduction pathways for a wide range of cellular processes. PTKs and PTPs are highly expressed in the central nervous system, which is consistent with the importance of tyrosine phosphorylation in neuronal function. Protein phosphorylation is known to be involved in the regulation of neurotransmitter receptors, but the effects of tyrosine phosphorylation on neurotransmitter receptor function in the central nervous system are unknown. Here we present evidence that in mammalian central neurons tyrosine phosphorylation regulates the function of the NMDA (N-methyl-D-aspartate) receptor, a subtype of excitatory amino-acid receptor. NMDA-receptor-mediated whole-cell currents and intracellular Ca2+ responses are depressed by inhibition of PTKs. Conversely, NMDA currents are potentiated by intracellular application of the well characterized PTK pp60c-src. NMDA currents are also potentiated by intracellular administration of an inhibitor of PTPs. Protein-tyrosine phosphorylation is a new mechanism for regulating NMDA receptors and may be important in neuronal development, plasticity and toxicity.

Essential role of Mash-2 in extraembryonic development.

Abstract: THE outer layer of the blastocyst, or trophectoderm, is the first cell lineage to differentiate in the mouse embryo1,2, but little is known about the genetic control of its development. Lineage-specific transcription factors may be important in lineage specification, and the product of the Mash-2 gene3,4 fulfils the criteria for such a factor. Mash-2 is a mammalian member of the achaete-scute family5–7 which encodes basic-helix–loop–helix transcription factors8 and is strongly expressed in the extraembryonic tropho-blast lineage. Mash-2 transcripts are found in the female germ line and in the embryo throughout preimplantation development, but are highly expressed later only in the ectoplacental cone, the chor-ion and their derivatives in the placenta. Mash-2 transcripts are not found in primary and secondary giant cells, yolk sac or allantois at any post-implantation stage, and are present only transiently and at low levels in the embryo during gastrulation. To analyse the role of Mash-2 in development, we have used gene targeting to generate mice having no Mash-2 function. We report here that Mash-2-/- embryos die from placental failure at 10 days post-coitum. In mutant placentas, spongiotrophoblast cells and their precursors are absent and chorionic ectoderm is reduced. We have rescued this placental mutant phenotype by constructing chimaeras with tetraploid wild-type embryos which contribute almost exclusively to extraembryonic tissues9,10. Mash-2-/- embryos developed normally and adult Mash-2-/- mice were viable, demonstrating that Mash-2 has no major role in the embryo itself. Mash-2 is the first transcription factor shown to play a critical part in the development of the mammalian trophoblast lineage.