Institution
Uppsala University Hospital
Healthcare•Uppsala, Sweden•
About: Uppsala University Hospital is a healthcare organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Cancer. The organization has 4402 authors who have published 7838 publications receiving 316292 citations. The organization is also known as: Akademiska Sjukhuset & Ackis.
Papers published on a yearly basis
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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) as discussed by the authors was used to estimate the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015.
5,050 citations
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TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
4,804 citations
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TL;DR: The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International ContinenceSociety.
4,293 citations
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TL;DR: Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hematologic cancer and death.
Abstract: Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent. Methods We analyzed data from whole-exome sequencing of DNA in peripheral-blood cells from 12,380 persons, unselected for cancer or hematologic phenotypes. We identified somatic mutations on the basis of unusual allelic fractions. We used data from Swedish national patient registers to follow health outcomes for 2 to 7 years after DNA sampling. Results Clonal hematopoiesis with somatic mutations was observed in 10% of persons older than 65 years of age but in only 1% of those younger than 50 years of age. Detectable clonal expansions most frequently involved somatic mutations in three genes (DNMT3A, ASXL1, and TET2) that have previously been implicated in hematologic cancers. Clonal hematopoiesis was a strong risk factor for subsequent hematologic cancer (hazard ratio, 12.9; 95% confidence interval, 5.8 to 28.7). Approximately 42% of hematologic cancers in this cohort arose in persons who had clonality at the time of DNA sampling, more than 6 months before a first diagnosis of cancer. Analysis of bone marrow–biopsy specimens obtained from two patients at the time of diagnosis of acute myeloid leukemia revealed that their cancers arose from the earlier clones. Conclusions Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hematologic cancer and death. A subset of the genes that are mutated in patients with myeloid cancers is frequently mutated in apparently healthy persons; these mutations may represent characteristic early events in the development of hematologic cancers. (Funded by the National Human Genome Research Institute and others.)
2,497 citations
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TL;DR: The procedure described is a promising new technique for the surgical treatment of female stress incontinence and Prospective long-term studies including more patients are in progress to establish the definitive place of this technique in the clinical routine.
Abstract: The object was to study prospectively the results of a modified intravaginal slingplasty for the surgical treatment of female stress incontinence, carried out under local anesthesia as a day procedure. Seventy five patients with genuine stress incontinence were operated upon and followed for a 2-year period. All patients were diagnosed urodynamically to have genuine stress incontinence. Pad tests and quality of life assessments were carried out in all patients both pre- and postoperatively. There were no intra- or postoperative complications and 63 patients (84%) were completely cured throughout the 2-year follow-up period. Six patients (8%) were significantly improved, i.e. they did not loose urine apart from an occasional leakage during severe cold etc. In the remaining 6 patients (8%) no improvement was seen. These failures were obvious at the first postoperative check-up after 2 months. Thus, there were no relapses after 2 months. All but 5 patients were able to void properly directly after surgery. These 5 needed an indwelling catheter during the night directly after the operation. All 75 patients were released from the hospital the same day or the day after surgery without catheterization. Mean sick leave was 10 days and mean operation time 22 minutes. No defect healing or rejection of the sling occurred. It is concluded that the procedure described is a promising new technique for the surgical treatment of female stress incontinence. Prospective long-term studies including more patients are in progress to establish the definitive place of this technique in the clinical routine.
1,781 citations
Authors
Showing all 4414 results
Name | H-index | Papers | Citations |
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Hans-Olov Adami | 145 | 908 | 83473 |
Dimitrios Trichopoulos | 135 | 818 | 84992 |
Alicja Wolk | 135 | 778 | 66239 |
Carl-Henrik Heldin | 131 | 520 | 67528 |
Lars Klareskog | 131 | 697 | 63281 |
Kerry L. Lee | 126 | 466 | 81906 |
Erik Ingelsson | 124 | 538 | 85407 |
Lars Wallentin | 124 | 767 | 61020 |
Lars Lind | 120 | 951 | 75475 |
Gerhard Andersson | 118 | 902 | 49159 |
Mathias Uhlén | 117 | 861 | 68387 |
Bjorn R. Olsen | 117 | 681 | 57961 |
Anders Ekbom | 116 | 613 | 51430 |
Lars Alfredsson | 112 | 607 | 51151 |
Bengt Glimelius | 111 | 829 | 61229 |