Journal ArticleDOI
A Systematic Review of Allostatic Load, Health, and Health Disparities
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TLDR
This systematic review examines the empirical literature that quantifies the allostasis and allostatic load construct and evaluates the social, environmental, and genetic antecedents of AL as well as its predictive utility for a variety of health outcomes.Abstract:
The theoretical constructs of allostasis and allostatic load (AL) have contributed to our understanding of how constantly changing social and environmental factors impact physiological functioning and shape health and aging disparities, particularly along socioeconomic, gendered, racial, and ethnic lines. AL represents the cumulative dysregulation of biological systems with prolonged or poorly regulated allostatic responses. Nearly two decades of empirical research has focused on operationalizing the AL construct for examining the antecedents and health outcomes accompanying multisystem biological dysregulation. The purpose of this systematic review is to examine the empirical literature that quantifies the AL construct; the review also evaluates the social, environmental, and genetic antecedents of AL as well as its predictive utility for a variety of health outcomes. A total of 58 articles published between 1997 and 2012 were retrieved, analyzed, and synthesized. The results revealed considerable heterogeneity in the operationalization of AL and the measurement of AL biomarkers, making interpretations and comparisons across studies challenging. There is, however, empirical substantiation for the relationships between AL and socioeconomic status, social relationships, workplace, lifestyle, race/ethnicity, gender, stress exposure, and genetic factors. The literature also demonstrated associations between AL and physical and mental health and all-cause mortality. Targeting the antecedents of AL during key developmental periods is essential for improving public health. Priorities for future research include conducting prospective longitudinal studies, examining a broad range of antecedent allostatic challenges, and collecting reliable measures of multisystem dysregulation explicitly designed to assess AL, at multiple time points, in population-representative samples.read more
Citations
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Journal ArticleDOI
Gender inequality and restrictive gender norms: framing the challenges to health
Lori Heise,Margaret E. Greene,Neisha Opper,Maria Stavropoulou,Caroline Harper,Marcos Nascimento,Debrework Zewdie,Gary L. Darmstadt,Margaret Eleanor Greene,Sarah Hawkes,Sarah Henry,Jody Heymann,Jeni Klugman,Ruth Levine,Anita Raj,Geeta Rao Gupta +15 more
TL;DR: This Series paper raises the parallel question of whether discrimination based on gender likewise becomes embodied, with negative consequences for health, as well as how gender-biased health research and health-care systems reinforce and reproduce gender inequalities, with serious implications for health.
Journal ArticleDOI
Allostatic Load and Its Impact on Health: A Systematic Review
TL;DR: It is indicated that allostatic load and overload are associated with poorer health outcomes and an integrated approach that includes both biological markers and clinimetric criteria is recommended.
Journal ArticleDOI
Effect of socioeconomic disparities on incidence of dementia among biracial older adults: prospective study.
Kristine Yaffe,Cherie Falvey,Tamara B. Harris,Anne B. Newman,Suzanne Satterfield,Annemarie Koster,Hilsa N. Ayonayon,Eleanor M. Simonsick +7 more
TL;DR: Findings suggest that differences in the burden of risk factors, especially socioeconomic status, may contribute to the higher rates of dementia seen among black compared with white older people.
Journal ArticleDOI
Adverse childhood experiences of low-income urban youth.
TL;DR: Gathering youth perspectives on childhood adversity broadens the understanding of the experience of stress and trauma in childhood and future work is needed to determine the significance of this broader set of adverse experiences in predisposing children to poor health outcomes as adults.
Journal ArticleDOI
Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort
Cristina Barboza Solís,Cristina Barboza Solís,Cristina Barboza Solís,Michelle Kelly-Irving,Michelle Kelly-Irving,Romain Fantin,Romain Fantin,Muriel Darnaudéry,Jérôme Torrisani,Thierry Lang,Thierry Lang,Cyrille Delpierre,Cyrille Delpierre +12 more
TL;DR: The results indicate that early psychosocial stress has an indirect lasting impact on physiological wear-and-tear via health behaviors, BMI, and socioeconomic factors in adulthood.
References
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TL;DR: This statement from the American Heart Association and the National Heart, Lung, and Blood Institute is intended to provide up-to-date guidance for professionals on the diagnosis and management of the metabolic syndrome in adults.
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TL;DR: This statement from the American Heart Association and the National Heart, Lung, and Blood Institute is intended to provide up-to-date guidance for professionals on the diagnosis and management of the metabolic syndrome in adults.
Journal ArticleDOI
Protective and Damaging Effects of Stress Mediators
TL;DR: The long-term effect of the physiologic response to stress is reviewed, which I refer to as allostatic load, which is the ability to achieve stability through change.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2012 Update A Report From the American Heart Association
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TL;DR: The American Heart Association's 2020 Impact Goals for Cardiovascular Diseases and Disorders are revealed, with a focus on preventing, treating, and preventing heart disease and stroke.