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Journal ArticleDOI

Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells

Henry Lai, +1 more
- 01 Jan 1995 - 
- Vol. 16, Iss: 3, pp 207-210
TLDR
Increases in brain cell DNA single-strand breaks were observed immediately as well as at 4 h postexposure in rats exposed for 2 h to continuous-wave 2450 MHz microwaves.
Abstract
Levels of DNA single-strand break were assayed in brain cells from rats acutely exposed to low-intensity 2450 MHz microwaves using an alkaline microgel electrophoresis method. Immediately after 2 h of exposure to pulsed (2 microseconds width, 500 pulses/s) microwaves, no significant effect was observed, whereas a dose rate-dependent [0.6 and 1.2 W/kg whole body specific absorption rate (SAR)] increase in DNA single-strand breaks was found in brain cells of rats at 4 h postexposure. Furthermore, in rats exposed for 2 h to continuous-wave 2450 MHz microwaves (SAR 1.2 W/kg), increases in brain cell DNA single-strand breaks were observed immediately as well as at 4 h postexposure.

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Citations
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Journal Article

Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz)

A Ahlbom
- 01 Jan 1998 - 
TL;DR: The International Commission on Non-Ionizing Radiation Protection (ICNIRP)—was established as a successor to the IRPA/INIRC, which developed a number of health criteria documents on NIR as part of WHO’s Environmental Health Criteria Programme, sponsored by the United Nations Environment Programme (UNEP).
Journal ArticleDOI

Single-and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation

TL;DR: No significant difference was observed between the effects of the two forms of radiation, and it is speculated that these effects could result from a direct effect of radiofrequency electromagnetic energy on DNA molecules and/or impairment of DNA-damage repair mechanisms in brain cells.
Journal ArticleDOI

Lymphomas in Eμ-Pim1 Transgenic Mice Exposed to Pulsed 900 MHz Electromagnetic Fields

TL;DR: Long-term intermittent exposure to RF fields can enhance the probability that mice carrying a lymphomagenic oncogene will develop lymphomas, and it is suggested that such genetically cancer-prone mice provide an experimental system for more detailed assessment of dose-response relationships for risk of cancer after RF-field exposure.
Journal ArticleDOI

Low-level exposure to radiofrequency electromagnetic fields: Health effects and research needs

TL;DR: It was concluded that, although hazards from exposure to high-level (thermal) RF fields were established, no known health hazards were associated with exposure to RF sources emitting fields too low to cause a significant temperature rise in tissue.
Journal ArticleDOI

Non-thermal DNA breakage by mobile-phone radiation (1800 MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro.

TL;DR: Cultured human diploid fibroblasts and cultured rat granulosa cells exposed to intermittent and continuous radiofrequency electromagnetic fields used in mobile phones, with different specific absorption rates (SAR) and different mobile-phone modulations, conclude that the induced DNA damage cannot be based on thermal effects.
References
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Journal ArticleDOI

A simple technique for quantitation of low levels of DNA damage in individual cells

TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
Journal ArticleDOI

Prooxidant states and tumor promotion.

Peter A. Cerutti
- 25 Jan 1985 - 
TL;DR: Prooxidant states can be caused by different classes of agents, including hyperbaric oxygen, radiation, xenobiotic metabolites and Fenton-type reagents, modulators of the cytochrome P-450 electron-transport chain, peroxisome proliferators, inhibitors of the antioxidant defense, and membrane-active agents.
Journal ArticleDOI

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

TL;DR: The ability of fibroblasts to perform unscheduled DNA synthesis after UV irradiation was measured radioautographically for seven species at several times after several UV fluences.
Journal ArticleDOI

Endogenous Oxidative DNA Damage, Aging, and Cancer

TL;DR: The endogenous background level of oxidant-induced DNA damage in vivo has been assayed and the level of oxidative DNA damage as measured by oh8dG in normal rat liver is shown to be extensive, especially in mtDNA.
Journal Article

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

TL;DR: The effects of topoisomerase II-reactive epipodophyllotoxins etoposide and teniposide as well as amsacrine on the viability of thymocytes in primary culture has been examined, indicating that topoisomersase II has a role in the very first stages of the process.
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