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Box-Behnken design: An alternative for the optimization of analytical methods

TLDR
The present paper describes fundamentals, advantages and limitations of the Box-Behnken design for the optimization of analytical methods, and establishes also a comparison between this design and composite central, three-level full factorial and Doehlert designs.
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This article is published in Analytica Chimica Acta.The article was published on 2007-08-10. It has received 2177 citations till now. The article focuses on the topics: Robustness (computer science).

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Citations
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Response surface methodology (RSM) as a tool for optimization in analytical chemistry

TL;DR: A review about the application of response surface methodology (RSM) in the optimization of analytical methods is presented and the theoretical principles and steps for its application are described to introduce readers to this multivariate statistical technique.
Journal ArticleDOI

Experimental design and multiple response optimization. Using the desirability function in analytical methods development

TL;DR: A review about the application of response surface methodology (RSM) when several responses have to be simultaneously optimized in the field of analytical methods development is presented.
Journal ArticleDOI

Modeling of competitive ultrasonic assisted removal of the dyes – Methylene blue and Safranin-O using Fe3O4 nanoparticles

TL;DR: In this paper, the simultaneous removal of Methylene blue (MB) and Safranin-O (SO), as most together hazardous dye in wastewater, from aqueous solution by ultra-sonic-assisted adsorption onto the developed adsorbent i.e. Fe3O4 NPs were synthesized, by using central composite design (CCD).
Journal ArticleDOI

Experimental design in chromatography: a tutorial review.

TL;DR: Two uses of DoE in chromatography are for showing lack of significant effects in robustness studies for method validation, and for identifying significant factors and then optimising a response with respect to them in method development.
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Evaluation of alcohol-based deep eutectic solvent in extraction and determination of flavonoids with response surface methodology optimization.

TL;DR: Deep eutectic solvents were used to extract flavonoids (myricetin and amentoflavone), which are well known and widely used antioxidants, to extend their applications and highlight their potential for the extraction and determination of a range of bioactive compounds or drugs.
References
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Journal ArticleDOI

Simultaneous Optimization of Several Response Variables

TL;DR: In this article, the authors present a set of conditions that will result in a product with a desirable combination of properties, which is a problem facing the product development community in general.
Journal ArticleDOI

Some New Three Level Designs for the Study of Quantitative Variables

TL;DR: In this paper, a class of incomplete three level factorial designs useful for estimating the coefficients in a second degree graduating polynomial are described and the designs either meet, or approximately meet, the criterion of rotatability and for the most part can be orthogonally blocked.
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