Brain abscess: Current management
Hernando Alvis Miranda,Sandra Milena Castellar-Leones,Mohammed Awad Elzain,Luis Rafael Moscote-Salazar +3 more
TLDR
The aim of this work is to review the current concepts regarding epidemiology, pathophysiology, etiology, clinical presentation, diagnosis, and management of brain abscess.Abstract:
Brain abscess (BA) is defined as a focal infection within the brain parenchyma, which starts as a localized area of cerebritis, which is subsequently converted into a collection of pus within a well-vascularized capsule. BA must be differentiated from parameningeal infections, including epidural abscess and subdural empyema. The BA is a challenge for the neurosurgeon because it is needed good clinical, pharmacological, and surgical skills for providing good clinical outcomes and prognosis to BA patients. Considered an infrequent brain infection, BA could be a devastator entity that easily left the patient into dead. The aim of this work is to review the current concepts regarding epidemiology, pathophysiology, etiology, clinical presentation, diagnosis, and management of BA.read more
Citations
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Journal ArticleDOI
Pediatric intracranial abscesses.
TL;DR: Intracranial infections in children are a relatively rare, but potentially severe condition that largely arise from direct extension of adjacent infection, hematogenous seeding, or trauma.
Journal ArticleDOI
Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats
Chi Hsiang Shih,Jen Kun Chen,Li-Wei Kuo,Kuan Hung Cho,Ta Chih Hsiao,Zhe Wei Lin,Yi Syuan Lin,Jiunn Horng Kang,Jiunn Horng Kang,Yu Chun Lo,Kai Jen Chuang,Tsun-Jen Cheng,Hsiao Chi Chuang +12 more
TL;DR: This study first observed cerebral edema and brain impairment in adult rats after chronic exposure to traffic-related air pollution.
Book ChapterDOI
CSF in acute and chronic infectious diseases.
Felix Benninger,Israel Steiner +1 more
TL;DR: This chapter is a guide-text that combines clinical presentation and course with CSF findings as a usuaful tool in diagnosis of neuroinfections.
Journal ArticleDOI
The Use of Adjunctive Steroids in Central Nervous Infections.
Shalini Gundamraj,Rodrigo Hasbun +1 more
TL;DR: It is described that while steroid therapy is beneficial and supported in pathogens such as pneumococcal meningitis and tuberculosis, for other diseases, like Listeria monocytogenes and Cryptococcus neoformans they are associated with worse outcomes.
Journal ArticleDOI
Clinical characteristics and course of primary brain abscess.
Nicole Lange,Maria Berndt,Ann-Kathrin Jörger,Arthur Wagner,Nina Wantia,Nina Lummel,Yu-Mi Ryang,Bernhard Meyer,Jens Gempt +8 more
TL;DR: One third of the patients with brain abscesses showed immunosuppressive conditions, whereas brain abscessiones also often occur in patients with good medical conditions, so the isolation of the focus of infection is often possible.
References
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Journal ArticleDOI
Brain abscess: a review of 400 cases
TL;DR: Early referral for specialist care, computerized tomography, correct choice and dosage of antibiotics, and the surgical methods in present use should make this a benign disease.
Journal ArticleDOI
MR imaging of brain abscesses.
Alison B. Haimes,Robert D. Zimmerman,Susan Morgello,Karen Weingarten,Richard D. Becker,Richard D. Becker,Richard Jennis,Michael D. F. Deck +7 more
TL;DR: The capsular intensity (in particular the hypointense rims on long TR scans) may reflect paramagnetic T1, and to a greater extent T2, shortening, possibly due to the presence of heterogeneously distributed free radicals that are products of the respiratory burst produced by actively phagocytosing macrophages in the capsule wall.
Journal ArticleDOI
The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18
Sushmita Jha,Siddharth Y. Srivastava,Willie June Brickey,Heather A. Iocca,Arrel D. Toews,James P. Morrison,Vivian S. Chen,Vivian S. Chen,Denis Gris,Glenn K. Matsushima,Jenny P.-Y. Ting +10 more
TL;DR: It is suggested that NLRP3 plays an important role in a model of multiple sclerosis by exacerbating CNS inflammation, and this is partly mediated by caspase-1 and IL-18.
Journal ArticleDOI
Acquired immune deficiency in Haitians: opportunistic infections in previously healthy Haitian immigrants.
TL;DR: Clinical and immunologic findings in these 10 Haitian men with acquired immune deficiency manifested by opportunistic infections are similar to those reported in drug addicts and homosexuals with the acquired immune-deficiency syndrome.
Journal ArticleDOI
Retrospective analysis of 49 cases of brain abscess and review of the literature
TL;DR: The case records of 49 patients discharged from St George’s Hospital, London, between December 2000 and March 2004 with the diagnosis ofbrain abscess were reviewed in order to document the epidemiology, causes, treatment, and prognostic factors associated with brain abscess.