Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis
TLDR
In this article, the authors dissect literature from the patient perspective, the tumor biology perspective, therapy-induced metastasis, and cell data generated in the laboratory to discover and investigate more targeted therapy with more efficacy.Abstract:
The lack of therapy and the failure of existing therapy has been a challenge for clinicians in treating various cancers. Doxorubicin, 5-fluorouracil, cisplatin, and paclitaxel are the first-line therapy in various cancers; however, toxicity, resistance, and treatment failure limit their clinical use. Their status leads us to discover and investigate more targeted therapy with more efficacy. In this article, we dissect literature from the patient perspective, the tumor biology perspective, therapy-induced metastasis, and cell data generated in the laboratory.read more
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Linking the future of anticancer metal-complexes to the therapy of tumour metastases
Alberta Bergamo,Gianni Sava +1 more
TL;DR: The capacity of NAMI-A to modulate the relationship established between metastatic cells and their microenvironment suggests that metal-based drugs shall be viewed as an opportunity for the treatment of tumour metastases.
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Resolvins suppress tumor growth and enhance cancer therapy.
Megan L. Sulciner,Charles N. Serhan,Molly M. Gilligan,Dayna Mudge,Jaimie Chang,Allison Gartung,Kristen Lehner,Diane R. Bielenberg,Birgitta Schmidt,Jesmond Dalli,Emily R. Greene,Yael Gus-Brautbar,Julia Piwowarski,Tadanori Mammoto,David Zurakowski,Mauro Perretti,Vikas P. Sukhatme,Arja Kaipainen,Mark W. Kieran,Sui Huang,Dipak Panigrahy +20 more
TL;DR: It is shown that tumor cells killed by chemotherapy or targeted therapy stimulate primary tumor growth when coinjected with a subthreshold (nontumorigenic) inoculum of tumor cells by triggering macrophage proinflammatory cytokine release after phosphatidylserine exposure.
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Curcumin as an anti-inflammatory agent: Implications to radiotherapy and chemotherapy.
Bagher Farhood,Keywan Mortezaee,Nasser Hashemi Goradel,Neda Khanlarkhani,Ensieh Salehi,Maryam Shabani Nashtaei,Masoud Najafi,Amirhossein Sahebkar +7 more
TL;DR: Evidence from clinical trials suggesting the potential utility of curcumin for acute inflammatory reactions during radiotherapy such as dermatitis and mucositis and low toxicity ofCurcumin is linked to its cytoprotective effects in normal tissues makes it a potential candidate for use as an adjuvant in cancer therapy.
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Off to the organelles - killing cancer cells with targeted gold nanoparticles.
TL;DR: This review summarizes the impact of AuNPs on selected subcellular organelles that are relevant to cancer therapy and focuses on the nucleus, its subcompartments, and mitochondria, because they are intimately linked to cancer cell survival, growth, proliferation and death.
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Chemoresistance and the Self-Maintaining Tumor Microenvironment.
TL;DR: This review discusses how the properties of the tumor microenvironment promote chemoresistance in cancer cells, and the interplay between these external stimuli, and how a chemoresistant phenotype emerges from the complex signaling network present.
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