Journal ArticleDOI
Comprehensive survey of combinatorial library synthesis: 2000.
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This article is published in ACS Combinatorial Science.The article was published on 2001-10-06. It has received 266 citations till now.read more
Citations
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The combinatorial synthesis of bicyclic privileged structures or privileged substructures
TL;DR: Privileged substructures are believed to achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns.
Journal ArticleDOI
Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis
Journal ArticleDOI
Paul Ehrlich's magic bullet concept: 100 years of progress.
Klaus Strebhardt,Axel Ullrich +1 more
TL;DR: The intellectual foundations of the development of cancer drug development are revisited, as many have shown great clinical success and are therefore appropriate to revisit.
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Navigating chemical space for biology and medicine
TL;DR: What are the best strategies for identifying small molecules that modulate biological targets?
Journal ArticleDOI
Biomedical Importance of Indoles
Nagendra Kumar Kaushik,Neha Kaushik,Pankaj Attri,Naresh Kumar,Chung Hyeok Kim,Akhilesh K. Verma,Eun Ha Choi +6 more
TL;DR: Some of the relevant and recent achievements in the biological, chemical and pharmacological activity of important indole derivatives in the areas of drug discovery and analysis are covered.
References
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Identification of a chemical tool for the orphan nuclear receptor FXR.
Patrick R. Maloney,Derek J. Parks,Curt D. Haffner,Adam M. Fivush,Gyan Chandra,Kelli D. Plunket,Katrina L. Creech,Linda B. Moore,Joan G. Wilson,Michael C. Lewis,Stacey A. Jones,Timothy M. Willson +11 more
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Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
David A. Matthews,P.S. Dragovich,S. E. Webber,Shella A. Fuhrman,Amy K. Patick,Leora S. Zalman,Thomas F. Hendrickson,R. A. Love,T. J. Prins,Marakovits Joseph T,R. Zhou,Jayashree Tikhe,Clifford E. Ford,James W. Meador,Rose Ann Ferre,Edward L. Brown,Susan L. Binford,D. M. Delisle,Stephen T. Worland +18 more
TL;DR: Cocrystal-structure-assisted optimization of 3C-protease-directed Michael acceptors has yielded molecules having extremely rapid in vitro inactivation of the viral protease, potent antiviral activity against multiple rhinovirus serotypes and low cellular toxicity.
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Comprehensive survey of combinatorial library synthesis: 1998.
Journal ArticleDOI
Small-Molecule Microarrays: Covalent Attachment and Screening of Alcohol-Containing Small Molecules on Glass Slides
Journal ArticleDOI
4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB.
C. J. Andres,Joanne J. Bronson,Stanley D'andrea,Milind Deshpande,Paul Falk,Katharine A. Grant-Young,William E. Harte,Hsu Tso Ho,Peter F. Misco,James G. Robertson,David A. Stock,Yaxiong Sun,Ann W. Walsh +12 more
TL;DR: Activity against the bacterial enzyme MurB supports the postulate that 4-thiazolidinones may be recognized as diphosphate mimics by a biological selector.