Consensus statement on the diagnosis of multiple system atrophy
Sid Gilman,Phillip A. Low,Niall Quinn,Alberto Albanese,Yoav Ben-Shlomo,C. J. Fowler,Horacio Kaufmann,Thomas Klockgether,Anthony E. Lang,P. L. Lantos,Irene Litvan,Christopher J. Mathias,E. Oliver,D. Robertson,Irwin J. Schatz,Gregor K. Wenning +15 more
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TLDR
The clinical features of the disease are described, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction, and criteria are set to define the relative importance of these features.Abstract:
We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poor levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.read more
Citations
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Journal ArticleDOI
Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
TL;DR: The vast majority of men > or =50 years old initially diagnosed with iRBD in this study eventually developed a parkinsonian disorder/dementia, often after a prolonged interval from onset of iR BD, with the mean interval being 14 years while the range extended to 29 years.
Journal ArticleDOI
Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS).
Gregor K. Wenning,François Tison,Klaus Seppi,Cristina Sampaio,Anja Diem,Farid Yekhlef,Imad Ghorayeb,Fabienne Ory,Monique Galitzky,Tommaso Scaravilli,M Bozi,Carlo Colosimo,Sid Gilman,Clifford W. Shults,Niall Quinn,Olivier Rascol,Werner Poewe +16 more
TL;DR: The UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients.
Journal ArticleDOI
Multiple system atrophy
TL;DR: Up-to-date knowledge on the clinical diagnosis and molecular pathology of MSA is summarized and the role of additional investigations that may support a clinical diagnosis are reviewed.
Journal ArticleDOI
Multiple system atrophy: an update
TL;DR: Advances in the early recognition of this disease have resulted in revised diagnostic criteria, including, for the first time, neuroimaging indices, and novel therapeutic options targeting disease modification have been investigated in clinical trials.
Journal ArticleDOI
MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy.
Aldo Quattrone,Giuseppe Nicoletti,Demetrio Messina,Francesco Fera,Francesca Condino,Pierfrancesco Pugliese,Pierluigi Lanza,Paolo Barone,Letterio Morgante,Mario Zappia,Umberto Aguglia,Olivier Gallo +11 more
TL;DR: The MR parkinsonism index can help distinguish patients with PSP from those with PD and MSA-P on an individual basis.
References
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Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) Report of the NINDS-SPSP International Workshop*
Irene Litvan,Yves Agid,Donald B. Calne,G. Campbell,Bruno Dubois,Roger C. Duvoisin,Christopher G. Goetz,Lawrence I. Golbe,Jordan Grafman,John H. Growdon,Mark Hallett,Joseph Jankovic,Niall Quinn,Eva Tolosa,David S. Zee +14 more
TL;DR: Criteria that support the diagnosis of progressive supranuclear palsy, and that exclude diseases often confused with PSP, are presented.
Journal ArticleDOI
Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy
Irwin J. Schatz,R. Bannister,Roy Freeman,Christopher G. Goetz,Joseph Jankovic,Horacio Kaufmann,William C. Koller,Phillip A. Low,Christopher J. Mathias,R. J. Polinsky,Niall Quinn,D. Robertson,D. H.P. Streeten +12 more
Journal ArticleDOI
Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy.
TL;DR: A Consensus Connce was convened on 16 November 1995 in Phoenix, Arizona, USA with the specific aim of generating a consensus on three specific items: the definition of orthostatic hypotension, pure autonomic failure (Bradbury Eggleston syndrome), and multiple system atrophy.
Journal ArticleDOI
Clinical features and natural history of multiple system atrophy. An analysis of 100 cases.
TL;DR: The clinical features and natural history of 100 patients diagnosed as probable multiple system atrophy (MSA) are described, and in all 14 cases who underwent post-mortem examination of the brain, the diagnosis was confirmed pathologically, providing some validation of the clinical diagnostic criteria used.
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