Current evidence and applications of photodynamic therapy in dermatology
Marilyn T. Wan,Jennifer Y. Lin +1 more
TLDR
The principles behind how PDT is used in dermatology are discussed, as well as evidence for current applications of PDT.Abstract:
In photodynamic therapy (PDT) a photosensitizer - a molecule that is activated by light - is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancer- ous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.read more
Citations
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Clinical development and potential of photothermal and photodynamic therapies for cancer
TL;DR: An overview of the current clinical progress of phototherapies for cancer and discuss the emerging preclinical bioengineering approaches that have the potential to overcome challenges in this area and thus improve the efficiency and utility of such treatments are provided.
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Light in diagnosis, therapy and surgery.
TL;DR: The fundamentals of light–matter interactions are revisited, the applications of light in imaging, diagnosis, therapy and surgery are described, their clinical use is overviewed, and the promise of emerging light-based technologies are discussed.
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Trends and targets in antiviral phototherapy
TL;DR: This review focuses on the PDI of viruses as an alternative treatment in antiviral therapy, but also as a means of viral decontamination, covering mainly the literature of the last decade.
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Application of Porphyrins in Antibacterial Photodynamic Therapy.
TL;DR: This review focuses on the application of porphyrins in the photo-inactivation of bacteria and Mechanisms of bacterial resistance and some of the current ‘greener’ methods of synthesis of meso-phenyl p Morphyrins are discussed.
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The potential of photodynamic therapy (PDT)-Experimental investigations and clinical use
TL;DR: Photodynamic therapy can be considered as promising treatment with comparable effectiveness but without side effects characteristic for chemotherapy.
References
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Journal ArticleDOI
Photodynamic therapy for cancer
TL;DR: PDT is being tested in the clinic for use in oncology — to treat cancers of the head and neck, brain, lung, pancreas, intraperitoneal cavity, breast, prostate and skin.
Journal ArticleDOI
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
Journal ArticleDOI
Mechanisms of photoaging and chronological skin aging
Gary J. Fisher,Sewon Kang,James Varani,Zsuzsanna Bata-Csorgo,Yinsheng Wan,Subhash C. Datta,John J. Voorhees +6 more
TL;DR: This article reviews the current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time and reveals that chronological aging and photoaging share fundamental molecular pathways.
Journal Article
Photodynamic therapy of cancer.
Thomas F. DeLaney,Eli Glatstein +1 more
TL;DR: Clinical trials with hematoporphyrin derivative PDT in the sites mentioned are in progress and laboratory work to better understand HpD also continues, as well as investigations into alternative photosensitizers with improved tumor localization, less cutaneous photosensitivity, and absorption peaks at deeper penetrating wavelengths of light.
Journal ArticleDOI
Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light.
TL;DR: Exposure of mouse and rat tumors of various types to more than 600 nm light 24 or 48 hours after an injection of hematoporphyrin resulted in a substantial number of long-term cures.
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