Definitions, variants, and causes of nonadherence with medication: a challenge for tailored interventions
TLDR
There is not just one solution for the nonadherence problem that fits all patients, and to improve adherence effectively, there is a need for a tailored approach based on the type and cause ofNonadherence and the specific needs of the patient.Abstract:
Background: Nonadherence with medication is a complex and multidimensional health care problem. The causes may be related to the patient, treatment, and/or health care provider. As a consequence, substantial numbers of patients do not benefit optimally from pharmacotherapy, resulting in increased morbidity and mortality as well as increased societal costs. Several interventions may contribute to improved adherence. However, most interventions have only a modest effect. Thus, despite the many efforts made, there has been little progress made as yet in tackling the problem of nonadherence. Methods: This paper summarizes the definitions and taxonomy of adherence with medication, as well as types and causes of nonadherence. In addition, interventions aimed at improvement of adherence are discussed. Conclusion: There is not just one solution for the nonadherence problem that fits all patients. Most interventions to improve adherence are aimed at all patients regardless of whether they are adherent or not. Recently, a number of tailored interventions have been described in the literature. Modern techniques are useful. Electronic pill boxes combined with Short Message Service reminders are specifically designed to improve unintentional adherence and have resulted in an increase in refill adherence in diabetic patients with suboptimal adherence. Tailored Internet interventions are a possibility for influencing patient drug-taking behavior and show promising results. Tailored counseling interventions targeted at the underlying causes of nonadherence seem an attractive method for supporting patients with their use of drugs. However, despite the plausible theoretical framework, data on long-term health effects of the various interventions are not available. To improve adherence effectively, there is a need for a tailored approach based on the type and cause of nonadherence and the specific needs of the patient. © 2013 Hugtenburg et al, publisher and licensee Dove Medical Press Ltd.read more
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Adherence to Antihypertensive Therapy
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References
More filters
Journal ArticleDOI
Adherence to long-term therapies: evidence for action.
TL;DR: This report highlights the need for a multi-disciplinary approach to adherence, emphasizes system factors that need to be addressed in successfully implementing adherence-enhancing strategies, and provides illustrative examples of the ways in which professionals have contributed in their own fields of expertise including cardiovascular care among other fields.
Journal ArticleDOI
Adherence to Long-Term Therapies: Evidence for Action:
Sabina De Geest,Eduardo Sabaté +1 more
TL;DR: In this paper, a comprehensive report entitled Adherence to Long-Term Therapies: Evidence for Action w1x was published, focusing on nine chronic conditions and their risk factors.
Journal ArticleDOI
Interventions for enhancing medication adherence.
Robby Nieuwlaat,Nancy L. Wilczynski,Tamara Navarro,Nicholas Hobson,Rebecca A. Jeffery,Arun Keepanasseril,Thomas Agoritsas,Niraj Mistry,Alfonso Iorio,Susan M. Jack,Bhairavi Sivaramalingam,Emma Iserman,Reem A. Mustafa,Dawn Jedraszewski,Chris Cotoi,R. Brian Haynes +15 more
TL;DR: The research in this field needs advances, including improved design of feasible long-term interventions, objective adherence measures, and sufficient study power to detect improvements in patient-important clinical outcomes.
Journal ArticleDOI
A systematic review of the associations between dose regimens and medication compliance
TL;DR: A review of studies that measured compliance using EM confirmed that the prescribed number of doses per day is inversely related to compliance.
Journal ArticleDOI
Medication Compliance and Persistence: Terminology and Definitions
Joyce A. Cramer,Anuja Roy,Anita Burrell,Carol J. Fairchild,Mahesh J. Fuldeore,Daniel A. Ollendorf,Peter K. Wong +6 more
TL;DR: Providing specific definitions for compliance and persistence is important for sound quantitative expressions of patients' drug dosing histories and their explanatory power for clinical and economic events and adoption by health outcomes researchers will provide a consistent framework and lexicon for research.