Describing the mechanism of antimicrobial peptide action with the interfacial activity model.
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An "interfacial activity model" is proposed, which is based on an experimentally testable molecular image of AMP-membrane interactions, which may be useful in driving engineering and design of novel AMPs.Abstract:
Antimicrobial peptides (AMPs) have been studied for three decades, and yet a molecular understanding of their mechanism of action is still lacking. Here we summarize current knowledge for both synthetic vesicle experiments and microbe experiments, with a focus on comparisons between the two. Microbial experiments are done at peptide to lipid ratios that are at least 4 orders of magnitude higher than vesicle-based experiments. To close the gap between the two concentration regimes, we propose an “interfacial activity model”, which is based on an experimentally testable molecular image of AMP–membrane interactions. The interfacial activity model may be useful in driving engineering and design of novel AMPs.read more
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TL;DR: Freeze-fracture electron microscopy revealed that vesicles produced at very high lipid concentrations exhibit size distributions and extent of multilamellar character comparable to systems produced at lower lipid levels.
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Sequence and specificity of two antibacterial proteins involved in insect immunity
TL;DR: It is believed that P9A and P9B play an important part in the humoral immune responses described previously and that the P9 proteins represent a new class of antibacterial agents for which the name cecropins is proposed.
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The co-evolution of host cationic antimicrobial peptides and microbial resistance
Andreas Peschel,Hans-Georg Sahl +1 more
TL;DR: It is proposed that CAMPs and CAMP-resistance mechanisms have co-evolved, leading to a transient host–pathogen balance that has shaped the existing CAMP repertoire.